Gene Expression Literature Summary

• Symbol: Hbb-b2
• Name: hemoglobin, beta adult minor chain
• ID: MGI:96022

28 matching records from 28 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E10	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	P
In situ RNA (section)	1	1		1	1	1	1	1		1	1			1	2
In situ RNA (whole mount)			1	1			1	1		1	1
RT-PCR	1	1		4	1		7	3		7	2	2	1	2	3
Nuclease S1				1			2	1		2		1			1
Primer Extension									1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hbb-b2  hemoglobin, beta adult minor chain   (Synonyms: beta2, beta min, beta minor globin)
Results	Reference
1*	J:190691 Barrow JJ, Masannat J, Bungert J, Neutralizing the function of a beta-globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17948-53
1*	J:119377 Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler KM, Lloyd JA, KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood. 2005 Oct 1;106(7):2566-71
1*	J:103896 Bultman SJ, Gebuhr TC, Magnuson T, A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005 Dec 1;19(23):2849-61
1	J:171578 Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X, Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
2*	J:69531 Dahm K, Nielsen PJ, Muller AM, Transcripts of fliz1, a nuclear zinc finger protein, are expressed in discrete foci of the murine fetal liver. Genomics. 2001 Apr 15;73(2):194-202
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:142972 Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS, UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 7;283(45):30461-70
1	J:170366 England SJ, McGrath KE, Frame JM, Palis J, Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood. 2011 Mar 3;117(9):2708-17
1	J:166627 Feng Y, Yang Y, Ortega MM, Copeland JN, Zhang M, Jacob JB, Fields TA, Vivian JL, Fields PE, Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood. 2010 Nov 25;116(22):4483-91
3*	J:28981 Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ, Groudine M, Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 1995 Sep 15;9(18):2203-13
1*	J:271614 Gudmundsdottir B, Gudmundsson KO, Klarmann KD, Singh SK, Sun L, Singh S, Du Y, Coppola V, Stockwin L, Nguyen N, Tessarollo L, Thorsteinsson L, Sigurjonsson OE, Gudmundsson S, Rafnar T, Tisdale JF, Keller JR, POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Rep. 2018 Jun 12;23(11):3236-3248
1	J:145362 Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S, Transcriptional interference among the murine beta-like globin genes. Blood. 2007 Mar 1;109(5):2210-6
2*	J:33053 Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ, Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol. 1996 Jun;16(6):2906-12
1	J:310414 Hung CH, Lee TL, Huang AY, Yang KC, Shyu YC, Wen SC, Lu MJ, Yuan S, Shen CJ, A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis. Int J Mol Sci. 2021 Jul 27;22(15)
9	J:133333 Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J, 'Maturational' globin switching in primary primitive erythroid cells. Blood. 2006 Feb 15;107(4):1665-72
2	J:153993 Liang SY, Moghimi B, Crusselle-Davis VJ, Lin IJ, Rosenberg MH, Li X, Strouboulis J, Huang S, Bungert J, Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor. Mol Cell Biol. 2009 Nov;29(21):5900-10
1	J:145398 Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG, Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1;110(3):870-6
1	J:73976 Lopez RA, Schoetz S, DeAngelis K, O'Neill D, Bank A, Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):602-7
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:43747 Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA , Pietryga DW , Scott WJ Jr , Potter SS, A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 1991 May 17;65(4):677-89
1	J:264340 Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W, Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol. 2011 Jun 26;13(8):944-51
1	J:224103 Papadopoulos P, Gutierrez L, Demmers J, Scheer E, Pourfarzad F, Papageorgiou DN, Karkoulia E, Strouboulis J, van de Werken HJ, van der Linden R, Vandenberghe P, Dekkers DH, Philipsen S, Grosveld F, Tora L, TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis. Mol Cell Biol. 2015 Jun;35(12):2103-18
4*	J:98851 Porcu S, Poddie D, Melis M, Cao A, Ristaldi MS, beta-Minor globin gene expression is preferentially reduced in EKLF Knock-Out mice. Gene. 2005 May 23;351:11-7
2	J:151995 Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH, Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27;460(7259):1093-7
4	J:239331 Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH, Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. 2016 Oct 05;128(19):2338-2342
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
10	J:52217 Trimborn T, Gribnau J, Grosveld F, Fraser P, Mechanisms of developmental control of transcription in the murine alpha-and beta-globin loci. Genes Dev. 1999 Jan 1;13(1):112-24
1	J:308797 Vinjamur DS, Yao Q, Cole MA, McGuckin C, Ren C, Zeng J, Hossain M, Luk K, Wolfe SA, Pinello L, Bauer DE, ZNF410 represses fetal globin by singular control of CHD4. Nat Genet. 2021 May;53(5):719-728