Hbb-b1
Gene Detail

Symbol Name ID

Hbb-b1 hemoglobin, beta adult major chain MGI:96021

Strain-Specific Marker

Synonyms

beta1, beta maj, beta major globin, MommeD7

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Alleles and phenotypes

All alleles(7) : Targeted(5) Chemically induced(2)
 

Homozygotes for a deletion of both adult hemoglobin-beta genes resemble human Cooley anemia and die perinatally. Heterozygotes are anemic with hematological abnormalities and iron accumulation. Homozygotes for a missense mutation have hemolytic anemia.

 
Human Diseases Modeled Using Mouse Hbb-b1 (2)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	erythrocyte development, hemopoiesis, ...
Component	hemoglobin complex
Function	oxygen transporter activity

External Resources: FuncBase

Expression

Literature Summary: (61 records)
Data Summary: Results (200)    Tissues (59)    Images (35)
Theiler Stages: 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	28
Northern blot	19
RT-PCR	145
Nuclease S1	8

cDNA source data(6)
External Resources: Allen Institute   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(16) cDNA(9) Primer pair(14) Other(1)
Microarray probesets(3)

Sequences

Length	Strain/Species
genomic	J00413	GenBank | EMBL | DDBJ | MGI Sequence Detail	6532	BALB/c

All sequences(5)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000008857	hemoglobin subunit beta-1

References

(Earliest) J:5898 Tilghman SM, et al., Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4406-10
(Latest) J:190446 Brown FC, et al., ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level. Blood Cells Mol Dis. 2013 Feb;50(2):86-92
All references(130)

Other accession IDs

MGD-MRK-10633, MGI:2145152, MGI:3821590