Gene Expression Literature Summary

• Symbol: Hbb-b1
• Name: hemoglobin, beta adult major chain
• ID: MGI:96021

76 matching records from 76 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)									2		1			1		1		1		1
In situ RNA (section)		2	1				2				3			4	1	1		1		1
In situ RNA (whole mount)			1		1		1		1		1	1		1	1
Northern blot	1		2											1		1				2
Western blot														1		1		1		1
RT-PCR	2	2	3	1	9	1	8	1	5	1	14	6		11	8	5	3	5	3	7
RNase protection									1										1
Nuclease S1							2				5	1		3		1				1
Primer Extension													1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hbb-b1  hemoglobin, beta adult major chain   (Synonyms: beta1, beta maj, beta major globin, MommeD7)
Results	Reference
1*	J:119377 Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler KM, Lloyd JA, KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo. Blood. 2005 Oct 1;106(7):2566-71
2	J:117669 Battista S, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A, Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation. FASEB J. 2003 Aug;17(11):1496-8
2*	J:49955 Belaoussoff M, Farrington SM, Baron MH, Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18
1	J:188652 Borges L, Iacovino M, Mayerhofer T, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Letarte M, Perlingeiro RC, A critical role for endoglin in the emergence of blood during embryonic development. Blood. 2012 Jun 7;119(23):5417-28
2*	J:190446 Brown FC, Scott N, Rank G, Collinge JE, Vadolas J, Vickaryous N, Whitelaw N, Whitelaw E, Kile BT, Jane SM, Curtis DJ, ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level. Blood Cells Mol Dis. 2013 Feb;50(2):86-92
1*	J:103896 Bultman SJ, Gebuhr TC, Magnuson T, A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005 Dec 1;19(23):2849-61
1	J:171578 Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X, Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
5	J:148823 Corrigan PM, Dobbin E, Freeburn RW, Wheadon H, Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev. 2009 Jun;18(5):759-72
1*	J:152211 Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P, Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia. 2009 Oct;57(13):1450-7
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:163754 Dumitriu B, Bhattaram P, Dy P, Huang Y, Quayum N, Jensen J, Lefebvre V, Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS One. 2010;5(8):e12088
2	J:142972 Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS, UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 7;283(45):30461-70
1	J:170366 England SJ, McGrath KE, Frame JM, Palis J, Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood. 2011 Mar 3;117(9):2708-17
1	J:166627 Feng Y, Yang Y, Ortega MM, Copeland JN, Zhang M, Jacob JB, Fields TA, Vivian JL, Fields PE, Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood. 2010 Nov 25;116(22):4483-91
3*	J:28981 Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ, Groudine M, Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 1995 Sep 15;9(18):2203-13
1	J:204573 Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T, Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam PP, Pearson RC, Crossley M, Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol. 2013 Aug;33(15):2976-87
1	J:235912 Ghanem LR, Kromer A, Silverman IM, Chatterji P, Traxler E, Penzo-Mendez A, Weiss MJ, Stanger BZ, Liebhaber SA, The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Mol Cell Biol. 2015 Nov 02;36(2):304-19
1*	J:271614 Gudmundsdottir B, Gudmundsson KO, Klarmann KD, Singh SK, Sun L, Singh S, Du Y, Coppola V, Stockwin L, Nguyen N, Tessarollo L, Thorsteinsson L, Sigurjonsson OE, Gudmundsson S, Rafnar T, Tisdale JF, Keller JR, POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin and Human Fetal Hemoglobin Expression. Cell Rep. 2018 Jun 12;23(11):3236-3248
1	J:145362 Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S, Transcriptional interference among the murine beta-like globin genes. Blood. 2007 Mar 1;109(5):2210-6
1*	J:93871 Huang J, Fan T, Yan Q, Zhu H, Fox S, Issaq HJ, Best L, Gangi L, Munroe D, Muegge K, Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res. 2004;32(17):5019-28
2*	J:33053 Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ, Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol. 1996 Jun;16(6):2906-12
1	J:182447 Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lu J, Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17;287(8):5979-87
1	J:259078 Johnson KD, Kong G, Gao X, Chang YI, Hewitt KJ, Sanalkumar R, Prathibha R, Ranheim EA, Dewey CN, Zhang J, Bresnick EH, Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv. 2015 Sep;1(8):e1500503
1	J:186500 Kaneko H, Kobayashi E, Yamamoto M, Shimizu R, N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program. J Biol Chem. 2012 Jun 15;287(25):21439-49
1*	J:65105 Keng VW, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, Tanaka T, Sato A, Muramatsu I, Okabe M, Sato M, Noguchi T, Homeobox gene hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61
4	J:141617 Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler KM, Crossley M, Dekker J, Perkins AC, A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol. 2008 May;141(3):398-406
1*	J:35594 Kieran MW, Perkins AC, Orkin SH, Zon LI, Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9126-31
1	J:123050 Kim I, Saunders TL, Morrison SJ, Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007 Aug 10;130(3):470-83
9	J:133333 Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J, 'Maturational' globin switching in primary primitive erythroid cells. Blood. 2006 Feb 15;107(4):1665-72
1	J:115610 Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H, Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001 Sep 1;98(5):1408-15
2	J:153993 Liang SY, Moghimi B, Crusselle-Davis VJ, Lin IJ, Rosenberg MH, Li X, Strouboulis J, Huang S, Bungert J, Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor. Mol Cell Biol. 2009 Nov;29(21):5900-10
1*	J:31156 Lin CS, Lim SK, D'Agati V, Costantini F, Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64
1	J:145398 Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG, Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1;110(3):870-6
1	J:73976 Lopez RA, Schoetz S, DeAngelis K, O'Neill D, Bank A, Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):602-7
1*	J:96898 Martin R, Lahlil R, Damert A, Miquerol L, Nagy A, Keller G, Hoang T, SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development. 2004 Feb;131(3):693-702
1	J:172821 McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J, A transient definitive erythroid lineage with unique regulation of the beta-globin locus in the mammalian embryo. Blood. 2011 Apr 28;117(17):4600-8
2	J:162666 Miccio A, Blobel GA, Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol. 2010 Jul;30(14):3460-70
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
2	J:202591 Mohn D, Chen SW, Dias DC, Weinstein DC, Dyer MA, Sahr K, Ducker CE, Zahradka E, Keller G, Zaret KS, Gudas LJ, Baron MH, Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Dev Dyn. 2003 Mar;226(3):446-59
1	J:43747 Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA , Pietryga DW , Scott WJ Jr , Potter SS, A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 1991 May 17;65(4):677-89
1	J:146843 Nagata M, Ito T, Arimitsu N, Koyama H, Sekimizu K, Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation. Genes Cells. 2009 Mar;14(3):371-80
1	J:116324 Nakajima O, Okano S, Harada H, Kusaka T, Gao X, Hosoya T, Suzuki N, Takahashi S, Yamamoto M, Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes. Genes Cells. 2006 Jun;11(6):685-700
2	J:264340 Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, Eussen B, de Klein A, Singer RH, de Laat W, Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol. 2011 Jun 26;13(8):944-51
2	J:25650 Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F, Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995 May 25;375(6529):316-8
7*	J:41559 Palis J, Robertson S, Kennedy M, Wall C, Keller G, Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999 Nov;126(22):5073-84
1	J:224103 Papadopoulos P, Gutierrez L, Demmers J, Scheer E, Pourfarzad F, Papageorgiou DN, Karkoulia E, Strouboulis J, van de Werken HJ, van der Linden R, Vandenberghe P, Dekkers DH, Philipsen S, Grosveld F, Tora L, TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis. Mol Cell Biol. 2015 Jun;35(12):2103-18
3	J:47299 Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN, Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95
2	J:25651 Perkins AC, Sharpe AH, Orkin SH, Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25;375(6529):318-22
4*	J:98851 Porcu S, Poddie D, Melis M, Cao A, Ristaldi MS, beta-Minor globin gene expression is preferentially reduced in EKLF Knock-Out mice. Gene. 2005 May 23;351:11-7
1*	J:146219 Postel EH, Wohlman I, Zou X, Juan T, Sun N, D'Agostin D, Cuellar M, Choi T, Notterman DA, La Perle KM, Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo. Dev Dyn. 2009 Mar;238(3):775-87
12	J:146606 Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS, Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 2009 Mar 1;69(5):1739-47
4*	J:106178 Rampon C, Huber P, Multilineage hematopoietic progenitor activity generated autonomously in the mouse yolk sac: analysis using angiogenesis-defective embryos. Int J Dev Biol. 2003 May;47(4):273-80
1*	J:77725 Regan CP, Li W, Boucher DM, Spatz S, Su MS, Kuida K, Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9248-53
1	J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
2	J:151995 Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH, Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27;460(7259):1093-7
1	J:261596 Schilders K, Eenjes E, Edel G, de Munck AB, van Kempen MB, Demmers J, Wijnen R, Tibboel D, Rottier RJ, Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo. Transgenic Res. 2018 Feb;27(1):75-85
1	J:71847 Shimizu R, Takahashi S, Ohneda K, Engel JD, Yamamoto M, In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis. EMBO J. 2001 Sep 17;20(18):5250-60
1	J:122680 Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M, GATA-1 self-association controls erythroid development in vivo. J Biol Chem. 2007 May 25;282(21):15862-71
2	J:163685 Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL, Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15151-6
4	J:239331 Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH, Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. 2016 Oct 05;128(19):2338-2342
3*	J:240319 Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A, Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188
2	J:132056 Strouboulis J, Dillon N, Grosveld F, Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice. Genes Dev. 1992 Oct;6(10):1857-64
1	J:115742 Takabayashi S, Katoh H, A mutant mouse with severe anemia and skin abnormalities controlled by a new allele of the flaky skin (fsn) locus. Exp Anim. 2005 Jul;54(4):339-47
1	J:63425 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M, Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
2	J:289448 Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou YS, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M, The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat Commun. 2011 Feb 8;2:181
12	J:52217 Trimborn T, Gribnau J, Grosveld F, Fraser P, Mechanisms of developmental control of transcription in the murine alpha-and beta-globin loci. Genes Dev. 1999 Jan 1;13(1):112-24
1*	J:285404 Ueda T, Yokota T, Okuzaki D, Uno Y, Mashimo T, Kubota Y, Sudo T, Ishibashi T, Shingai Y, Doi Y, Ozawa T, Nakai R, Tanimura A, Ichii M, Ezoe S, Shibayama H, Oritani K, Kanakura Y, Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver. Stem Cell Reports. 2019 Dec 10;13(6):992-1005
1	J:56429 Vannucchi AM, Linari S, Lin CS, Koury MJ, Bondurant MC, Migliaccio AR, Increased expression of the distal, but not of the proximal, Gata1 transcripts during differentiation of primary erythroid cells. J Cell Physiol. 1999 Sep;180(3):390-401
1	J:308797 Vinjamur DS, Yao Q, Cole MA, McGuckin C, Ren C, Zeng J, Hossain M, Luk K, Wolfe SA, Pinello L, Bauer DE, ZNF410 represses fetal globin by singular control of CHD4. Nat Genet. 2021 May;53(5):719-728
2*	J:340074 Wu J, Moriwaki K, Asuka T, Nakai R, Kanda S, Taniguchi M, Sugiyama T, Yoshimura SI, Kunii M, Nagasawa T, Hosen N, Miyoshi E, Harada A, EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Blood Adv. 2023 Jul 25;7(14):3382-3394
1	J:97254 Yagishita N, Ohneda K, Amano T, Yamasaki S, Sugiura A, Tsuchimochi K, Shin H, Kawahara K, Ohneda O, Ohta T, Tanaka S, Yamamoto M, Maruyama I, Nishioka K, Fukamizu A, Nakajima T, Essential role of synoviolin in embryogenesis. J Biol Chem. 2005 Mar 4;280(9):7909-16
2	J:127025 Yasuda Y, Sasaki T, Takagawa M, Maeda M, Yasuda M, Atsumi T, Fujita Y, Fujita H, Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice. Congenit Anom (Kyoto). 2007 Mar;47(1):22-33
3*	J:115753 Yi Z, Cohen-Barak O, Hagiwara N, Kingsley PD, Fuchs DA, Erickson DT, Epner EM, Palis J, Brilliant MH, Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genet. 2006 Feb;2(2):e14
1*	J:116886 Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT, Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006 Sep 1;281(35):25703-11
1	J:137915 Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY, Suh PG, Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol. 2008 Aug;28(15):4794-804
1*	J:65668 Zafarana G, Rottier R, Grosveld F, Philipsen S, Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesis. EMBO J. 2000 Nov 1;19(21):5856-63