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Gnao1
Gene Detail
Symbol

Name
ID
Gnao1
guanine nucleotide binding protein, alpha O
MGI:95775
Synonyms
alphaO, Galphao, GO, Go alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 8
45.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr8:93809966-93969388 bp, + strand
From VEGA annotation of GRCm38

  159423 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAO1
Gene Tree: Gnao1

Human
homologs
GNAO1, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2775
neXtProt AC: NX_P09471

Human Synonyms: EIEE17, G-ALPHA-o, GNAO

Human Chr (Location): 16q13; chr16:56191339-56357444 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GNAO1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(2) Targeted(14)
Incidental mutations (data from APF , CvDC )
 
Mice lacking both isoforms exhibit reduced survival, sterility, low body weight, hyperalgesia, tremors, turning behavior, impaired locomotion, altered channel response and improved glucose tolerance. Isoform-specific deletion may lead to increased insulin release and abnormal eye electrophysiology.
 
Interactions
Gnao1 interacts with 303 markers (Mir1b, Mir7-1, Mir9-1, ...)
Expression
Literature Summary: (32 records)
Data Summary: Results (353)    Tissues (202)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 303
Western blot 19
RT-PCR 12
cDNA source data(176)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GNAO1 ; Xenbase gnao1 ; ZFIN gnao1b    NEW 
Molecular
reagents
All nucleic(184) Genomic(1) cDNA(178) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000034033 (Evidence)
Ensembl Gene Model ENSMUSG00000031748 (Evidence)
Entrez Gene 14681 (Evidence)
UniGene 251445
DFCI TC1576589, TC1583311, TC1584512, TC1606255, TC1608149, TC1617170
NIA Mouse Gene Index U009648
PDB 3C7K
Consensus CDS Project CCDS22532.1
International Mouse Phenotyping Consortium Status Gnao1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034033 VEGA Gene Model | MGI Sequence Detail 159423 C57BL/6J ±  kb
transcript OTTMUST00000085915 VEGA | MGI Sequence Detail 2948 Not Applicable 
polypeptide OTTMUSP00000046457 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(7) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(910 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008089 guanine nucleotide-binding protein G(o) subunit alpha
References
(Earliest) J:31017 Itoh H, et al., Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3776-80
(Latest) J:216850 Kehrl JM, et al., Gain-of-function mutation in Gnao1: a murine model of epileptiform encephalopathy (EIEE17)?. Mamm Genome. 2014 Jun;25(5-6):202-10
All references(111)
Other
accession IDs
MGD-MRK-10187, MGI:2142753

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory