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Gnao1
Gene Detail
Symbol

Name
ID
Gnao1
guanine nucleotide binding protein, alpha O
MGI:95775
Synonyms
alphaO, Galphao, GO, Go alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 8
45.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr8:93809966-93969388 bp, + strand
From VEGA annotation of GRCm38

  159423 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnao1

Human
homologs
Human Homolog GNAO1, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
NCBI Gene ID 2775
neXtProt AC  NX_P09471
Human Synonyms  EIEE17, G-ALPHA-o, GNAO
Human Chr (Location)  16q13; chr16:56191339-56357444 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNAO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(2) Targeted(13)
Incidental mutations (data from APF )
 
Mice lacking both isoforms exhibit reduced survival, sterility, low body weight, hyperalgesia, tremors, turning behavior, impaired locomotion, altered channel response and improved glucose tolerance. Isoform-specific deletion may lead to increased insulin release and abnormal eye electrophysiology.
 
Interactions
Gnao1 interacts with 304 markers (Mir1b, Mir7-1, Mir9-1, ...)
Expression
Literature Summary: (32 records)
Data Summary: Results (353)    Tissues (202)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 303
Western blot 19
RT-PCR 12
cDNA source data(176)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(184) Genomic(1) cDNA(178) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000034033 (Evidence)
Ensembl Gene ModelENSMUSG00000031748 (Evidence)
Entrez Gene14681 (Evidence)
UniGene251445
DFCITC1576589, TC1583311, TC1584512, TC1606255, TC1608149, TC1617170
NIA Mouse Gene IndexU009648
PDB3C7K
Consensus CDS ProjectCCDS22532.1
International Mouse Knockout Project StatusGnao1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034033 VEGA Gene Model | MGI Sequence Detail 159423 C57BL/6J ±  kb
transcript OTTMUST00000085915 VEGA | MGI Sequence Detail 2948 Not Applicable 
polypeptide OTTMUSP00000046457 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(5) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(910 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008089 guanine nucleotide-binding protein G(o) subunit alpha
References
(Earliest) J:31017 Itoh H, et al., Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3776-80
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(110)
Other
accession IDs
MGD-MRK-10187, MGI:2142753

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory