Sequence Detail

ID/Version

P18872 P18873 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=Guanine nucleotide-binding protein G(o) subunit alpha; EC=3.6.5.- {ECO:0000269|PubMed:10926822};

Provider

SWISS-PROT

Sequence

Polypeptide 354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gnao1	guanine nucleotide binding protein, alpha O	82	128	4	27

Sequence references in MGI

J:30992 Strathmann M, et al., Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6477-81
J:39013 Valenzuela D, et al., G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1727-32
J:46898 Jiang M, et al., Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3269-74
J:68071 Jiang M, et al., Most central nervous system D2 dopamine receptors are coupled to their effectors by Go. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3577-82
J:172908 Traver S, et al., RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J. 2000 Aug 15;350 Pt 1:19-29
J:201289 Vowinckel J, et al., Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling. FEBS Lett. 2012 Nov 2;586(21):3819-24
J:216850 Kehrl JM, et al., Gain-of-function mutation in Gnao1: a murine model of epileptiform encephalopathy (EIEE17)?. Mamm Genome. 2014 Jun;25(5-6):202-10
J:248218 Slep KC, et al., Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6243-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:381518 Nakata H, et al., Functional characterization of Galphao signaling through G protein-regulated inducer of neurite outgrowth 1. Mol Pharmacol. 2005 Mar;67(3):695-702