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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gnao1
guanine nucleotide binding protein, alpha O
MGI:95775
71 phenotypes from 13 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gnao1em1Rneu/Gnao1+
involves: C57BL/6J * C57BL/6NCrl 		abnormal gait J:271137
abnormal motor capabilities/coordination/movement J:271137
decreased grip strength J:271137
impaired coordination J:271137
increased kindling response J:271137
premature death J:271137
short stride length J:271137
Gnao1em1Rneu/Gnao1em1Rneu
involves: C57BL/6J * C57BL/6NCrl 		neonatal lethality, complete penetrance J:271137
Gnao1em2Rneu/Gnao1+
C57BL/6J-Gnao1em2Rneu 		abnormal response to new environment J:303229
normal behavior/neurological phenotype J:303229
hyperactivity J:303229
impaired exercise endurance J:303229
increased thigmotaxis J:303229
short stride length J:303229
Gnao1tm1Adhi/Gnao1tm1Adhi
Not Specified 		abnormal cone electrophysiology J:125588
abnormal eye electrophysiology J:125588
Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H 		abnormal bone structure J:211773
decreased anxiety-related response J:211773
decreased bone mineral content J:211773
decreased circulating iron level J:211773
decreased circulating serum albumin level J:211773
decreased eosinophil cell number J:211773
decreased erythrocyte cell number J:211773
decreased fasting circulating glucose level J:211773
decreased red blood cell distribution width J:211773
decreased respiratory quotient J:211773
hyperactivity J:211773
impaired righting response J:211773
increased blood urea nitrogen level J:211773
increased circulating amylase level J:211773
increased circulating creatinine level J:211773
increased circulating triglyceride level J:211773
increased mean corpuscular hemoglobin J:211773
Gnao1tm1b(EUCOMM)Hmgu/Gnao1tm1b(EUCOMM)Hmgu
C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Gnao1tm1Ejne/Gnao1+
involves: 129S4/SvJae 		normal behavior/neurological phenotype J:216850
Gnao1tm1Ejne/Gnao1tm1Ejne
involves: 129S4/SvJae * C57BL/6 		abnormal channel response J:39013
abnormal myocardial fiber physiology J:39013
neonatal lethality, incomplete penetrance J:39013
postnatal lethality, incomplete penetrance J:39013
premature death J:39013
sporadic seizures J:39013
tremors J:39013
Gnao1tm1Lbi/Gnao1tm1Lbi
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal channel response J:46898
abnormal social investigation J:46898
decreased body size J:46898
decreased body weight J:46898
decreased thermal nociceptive threshold J:46898
hyperactivity J:46898
hyperalgesia J:46898
impaired coordination J:46898
infertility J:46898
premature death J:46898
preweaning lethality, incomplete penetrance J:46898
tremors J:46898
unidirectional circling J:46898
Gnao1tm2.1Rneu/Gnao1+
129S-Gnao1tm2.1Rneu 		normal behavior/neurological phenotype J:216850
normal mortality/aging J:216850
Gnao1tm2.1Rneu/Gnao1+
(C57BL/6J x 129S1/SvImJ)F1 		normal behavior/neurological phenotype J:216850
normal mortality/aging J:216850
Gnao1tm2.1Rneu/Gnao1+
B6.129S-Gnao1tm2.1Rneu 		abnormal kindling response J:216850
abnormal nervous system physiology J:216850
postnatal lethality, incomplete penetrance J:216850
premature death J:216850
Gnao1tm2.1Rneu/Gnao1tm2.1Rneu
B6.129S-Gnao1tm2.1Rneu 		lethality, incomplete penetrance J:216850
Gnao1tm2Adhi/Gnao1tm2Adhi
Not Specified 		normal vision/eye phenotype J:125588
Gnao1tm2Lbi/Gnao1tm2Lbi
involves: 129S7/SvEvBrd 		abnormal eye electrophysiology J:168245
abnormal locomotor behavior J:168245
abnormal survival J:168245
normal homeostasis/metabolism phenotype J:168245
tremors J:168245
Gnao1tm2Rneu/Gnao1+
B6.129S1-Gnao1tm2Rneu 		abnormal gait J:271137
decreased exploration in new environment J:271137
decreased grip strength J:271137
decreased locomotor activity J:271137
impaired coordination J:271137
short stride length J:271137
Gnao1tm2Rneu/Gnao1+
involves: 129S1/Sv * C57BL/6J 		abnormal spike wave discharge J:197965
Gnao1tm2Rneu/Gnao1tm2Rneu
involves: 129S1/Sv * C57BL/6J 		lethality, complete penetrance J:197965
Gnao1tm3Lbi/Gnao1tm3Lbi
involves: 129S7/SvEvBrd 		abnormal hormone level J:168245
decreased circulating glucose level J:168245
improved glucose tolerance J:168245
increased circulating insulin level J:168245
increased insulin secretion J:168245
Gnao1tm4.1Lbi/Gnao1tm4.1Lbi
Not Specified 		abnormal behavior J:169627
abnormal body size J:169627
abnormal reproductive system physiology J:169627
abnormal survival J:169627
Gnao1tm4Lbi/Gnao1tm4Lbi
Omptm4(cre)Mom/?
involves: 129P2/OlaHsd * C57BL/6J 		abnormal behavior J:279957
abnormal vomeronasal sensory neuron physiology J:279957
Gnao1tm4Lbi/Gnao1tm4Lbi
Tg(Pdx1-cre)89.1Dam/0
involves: C57BL/6 * CBA 		abnormal glucose tolerance J:169627
abnormal pancreas morphology J:169627
abnormal pancreatic beta cell physiology J:169627
decreased pancreatic beta cell mass J:169627
increased circulating insulin level J:169627
increased insulin secretion J:169627
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory