Symbol
Name
ID

Gnao1
guanine nucleotide binding protein, alpha O
MGI:95775

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Self-injurious behavior
Disease(s) Associated with GNAO1	Self-injurious behavior
neurodevelopmental disorder with involuntary movements

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavior

abnormal response to new environment

decreased exploration in new environment

decreased anxiety-related response

increased thigmotaxis

abnormal motor capabilities/coordination/movement

impaired righting response

tremors

impaired coordination

decreased grip strength

abnormal locomotor behavior

abnormal gait

short stride length

decreased locomotor activity

hyperactivity

unidirectional circling

hyperalgesia

decreased thermal nociceptive threshold

abnormal social investigation

impaired exercise endurance

abnormal kindling response

increased kindling response

abnormal spike wave discharge

sporadic seizures

Availability

Mouse Genotype

Gnao1^tm1Ejne/Gnao1^tm1Ejne

Gnao1^tm1Lbi/Gnao1^tm1Lbi

Gnao1^tm2Lbi/Gnao1^tm2Lbi

Gnao1^tm4.1Lbi/Gnao1^tm4.1Lbi

Gnao1^em1Rneu/Gnao1⁺

Gnao1^em2Rneu/Gnao1⁺

Gnao1^{tm1b(EUCOMM)Hmgu}/Gnao1⁺

Gnao1^tm1Ejne/Gnao1⁺

Gnao1^tm2.1Rneu/Gnao1⁺

Gnao1^tm2Rneu/Gnao1⁺

Gnao1^tm4Lbi/Gnao1^tm4Lbi
Omp^tm4(cre)Mom/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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