Phenotypes Associated with This Genotype

Genotype
MGI:6513140

• Allelic Composition: Gnao1^em2Rneu/Gnao1⁺
• Genetic Background: C57BL/6J-Gnao1^em2Rneu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:303229 )

N • mice exhibit no overt postural or movement abnormalities or seizures under normal housing conditions

N • mice do not show increased susceptibility to PTZ kindling-induced seizures

abnormal response to new environment ( J:303229 )

♀ • females, but not males, show increased activity in the first 10 minutes (novelty period) in the open field arena

increased thigmotaxis ( J:303229 )

• mice display reduced time in the center of the open field arena, possibly indicating anxiety-like behavior

short stride length ( J:303229 )

♂ • males show a modestly reduced stride length

♂ • however, no difference in paw angle variability is seen in either males or females

hyperactivity ( J:303229 )

• mice show increased activity in the open field arena in the sustained activity period

• however, mice show no differences on the rotarod or grip strength test

• mice treated with risperidone, an atypical antipsychotic drug, show attenuation of hyperactivity; risperidone also reduces activity of wild-type mice

impaired exercise endurance ( J:303229 )

♀ • females show a reduced maximum run speed on the treadmill

homeostasis/metabolism

impaired exercise endurance ( J:303229 )

♀ • females show a reduced maximum run speed on the treadmill

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neurodevelopmental disorder with involuntary movements		DOID:0112276	OMIM:617493	J:303229