Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
|Process||activation of MAPKK activity, anatomical structure formation involved in morphogenesis, ...|
|Component||cytoplasm, extracellular region, ...|
|Function||BMP receptor binding, chemoattractant activity, ...|
|InterPro||IPR017948||Transforming growth factor beta, conserved site|
|InterPro||IPR001839||Transforming growth factor-beta, C-terminal|
|InterPro||IPR001111||Transforming growth factor-beta, N-terminal|
|InterPro||IPR015615||Transforming growth factor-beta-related|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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