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Bmp4 Gene Detail
Summary
  • Symbol
    Bmp4
  • Name
    bone morphogenetic protein 4
  • Synonyms
    Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88180
    NCBI Gene: 12159
  • Gene Overview
    MyGene.info: BMP4
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:46383525-46390669 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 23.95 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88180
protein coding gene Chr14:46383520-46390669 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021212
protein coding gene Chr14:40049812-40058693 (-)
A/J MGP_AJ_G0021159
protein coding gene Chr14:38862241-38869377 (-)
AKR/J MGP_AKRJ_G0021137
protein coding gene Chr14:40371788-40381074 (-)
BALB/cJ MGP_BALBcJ_G0021163
protein coding gene Chr14:38916652-38924054 (-)
C3H/HeJ MGP_C3HHeJ_G0020946
protein coding gene Chr14:40160734-40169701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021597
protein coding gene Chr14:41791348-41803352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019156
protein coding gene Chr14:38241791-38248800 (-)
CAST/EiJ MGP_CASTEiJ_G0020471
protein coding gene Chr14:37280999-37288520 (-)
CBA/J MGP_CBAJ_G0020912
protein coding gene Chr14:43114256-43125101 (-)
DBA/2J MGP_DBA2J_G0021035
protein coding gene Chr14:38768561-38776002 (-)
FVB/NJ MGP_FVBNJ_G0021020
protein coding gene Chr14:38508353-38515470 (-)
LP/J MGP_LPJ_G0021105
protein coding gene Chr14:40334504-40341630 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021045
protein coding gene Chr14:42514032-42522150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021630
protein coding gene Chr14:39923424-39931484 (-)
PWK/PhJ MGP_PWKPhJ_G0020220
protein coding gene Chr14:35631800-35639670 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020044
protein coding gene Chr14:36068423-36076035 (-)
WSB/EiJ MGP_WSBEiJ_G0020527
protein coding gene Chr14:40022667-40032540 (-)



Homology
more
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
  • Links
    NCBI Gene ID: 652
    neXtProt AC: NX_P12644
    UniProt: P12644

  • Chr Location
    14q22.2; chr14:53949736-53956862 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    6 with Bmp4 mouse models; 2 with human BMP4 associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    238 phenotypes from 15 alleles in 35 genetic backgrounds
    133 phenotypes from multigenic genotypes
    10 images
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12159 NCBI Gene Model | MGI Sequence Detail 7145 C57BL/6J ±  kb
    transcript NM_007554 RefSeq | MGI Sequence Detail 2059 C57BL/6  
    polypeptide P21275 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      Genomic 1
      cDNA 59
      Primer pair 24
      Other 76

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602
    References
    more
    • Summaries
      All 1276
      Developmental Gene Expression 1020
      Diseases 6
      Gene Ontology 99
      Phenotypes 148
    • Earliest
      J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
    • Latest
      J:266477 Wang Y, et al., Myocardial beta-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation. J Mol Cell Cardiol. 2018 Sep 8;123:150-158

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory