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Bmp4 Gene Detail
Summary
  • Symbol
    Bmp4
  • Name
    bone morphogenetic protein 4
  • Synonyms
    Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88180
    NCBI Gene: 12159
  • Gene Overview
    MyGene.info: BMP4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:46383520-46390669 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7150 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 23.95 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
  • Links
    NCBI Gene ID: 652
    neXtProt AC: NX_P12644
    UniProt: P12644

  • Chr Location
    14q22.2; chr14:53949736-53956862 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    6 with Bmp4 mouse models; 2 with human BMP4 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    238 phenotypes from 15 alleles in 35 genetic backgrounds
    133 phenotypes from multigenic genotypes
    10 images
    147 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    291
  • GO References
    98
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1736
  • Tissues
    796
  • cDNA Data
    47
  • Literature Summary
    1016
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019526 VEGA Gene Model | MGI Sequence Detail 7150 C57BL/6J ±  kb
    transcript OTTMUST00000046636 VEGA | MGI Sequence Detail 2064 Not Applicable  
    polypeptide OTTMUSP00000021065 VEGA | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      75 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 159
      Genomic 1
      cDNA 59
      Primer pair 24
      Other 75

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602
    References
    more
    • Summaries
      All 1272
      Developmental Gene Expression 1016
      Diseases 6
      Gene Ontology 98
      Phenotypes 147
    • Earliest
      J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
    • Latest
      J:265181 Kim BJ, et al., RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects. Dis Model Mech. 2018 Aug 28;11(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory