Bmp4
Gene Detail

Symbol Name ID

Bmp4 bone morphogenetic protein 4 MGI:88180

Synonyms

Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4

Feature Type

protein coding gene

Genetic Map

Chromosome 14

23.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr14:46383520-46390669 bp, - strand From VEGA annotation of GRCm38   7150 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp4

Human homologs

Human Homolog		BMP4, bone morphogenetic protein 4
NCBI Gene ID		652
neXtProt AC		NX_P12644
Human Synonyms		BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
Human Chr (Location)		14q22-q23; chr14:54416454-54423554 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human BMP4

Alleles and phenotypes

All alleles(24) : Targeted(16) Gene trapped(8)
 

Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.

 
Human Diseases Modeled Using Mouse Bmp4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (234 annotations)

Process	activation of MAPKK activity, anatomical structure formation involved in morphogenesis, ...
Component	cytoplasm, extracellular region, ...
Function	BMP receptor binding, chemoattractant activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (774 records)
Data Summary: Results (1264)    Tissues (643)    Images (399)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	1089
In situ reporter (knock in)	67
Northern blot	22
RT-PCR	82

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(127) Genomic(1) cDNA(74) Primer pair(17) Other(35)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000019526 (Evidence)
Ensembl Gene Model	ENSMUSG00000021835 (Evidence)
Entrez Gene	12159 (Evidence)
UniGene	6813
DFCI	TC1584053, TC1596765, TC1747376
DoTS	DT.522369
Consensus CDS Project	CCDS36897.1
International Mouse Knockout Project Status	Bmp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019526	VEGA Gene Model | MGI Sequence Detail	7150	C57BL/6J
transcript	OTTMUST00000046636	VEGA | MGI Sequence Detail	2064	Not Applicable
polypeptide	OTTMUSP00000021065	VEGA | MGI Sequence Detail	408	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000165	BMP4

References

(Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:195212 Qian SW, et al., BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E798-807
All references(948)

Other accession IDs

MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602