Bmp4 MGI Mouse Gene Detail - MGI:88180 - bone morphogenetic protein 4

Bmp4 Gene Detail

Symbol

Bmp4
Name

bone morphogenetic protein 4
Synonyms

Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4

Feature Type

protein coding gene
IDs

MGI:88180
NCBI Gene: 12159
Gene Overview

MyGene.info: BMP4

Sequence Map

Chr14:46383520-46390669 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

7150 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 23.95 cM
Mapping Data

8 experiments

Human Ortholog

BMP4, bone morphogenetic protein 4

Vertebrate Orthologs

10

Human Ortholog

BMP4, bone morphogenetic protein 4
Orthology source: HomoloGene, HGNC
Synonyms

BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
Links

HGNC:1071

NCBI Gene ID: 652

neXtProt AC: NX_P12644
Chr Location

14q22-q23; chr14:53949736-53956836 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 7247
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: BMP4
Protein SuperFamily

bone morphogenetic protein
Gene Tree

Bmp4

Diseases

3 with Bmp4 mouse models; 2 with human BMP4 associations

Human Disease

Mouse Models

Atrioventricular Septal Defect; AVSD OMIM: 606215

View 2 models

Axenfeld-Rieger Syndrome, Type 3; RIEG3 OMIM: 602482

View 1 model

Fibrodysplasia Ossificans Progressiva; FOP OMIM: 135100

View 1 model

Microphthalmia, Syndromic 6; MCOPS6 OMIM: 607932

Orofacial Cleft 11; OFC11 OMIM: 600625

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

4 with disease annotations

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Phenotype Summary

216 phenotypes from 14 alleles in 33 genetic backgrounds
132 phenotypes from multigenic genotypes
10 images
133 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Gene trapped

8
Targeted

19
Transgenic

4
Genomic Mutations

1 involving Bmp4
Incidental Mutations

Mutagenetix , APF

Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.

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All GO Annotations

278
GO References

97

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1573
Tissues

729
cDNA Data

45
Literature Summary

927

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA BMP4

Xenbase bmp4

ZFIN bmp4

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Bmp4 interacts with 50 markers (Mir17, Mir20a, Mir106b, ...) View All

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All Sequences

37
RefSeq

12
UniProt

2
CCDS

CCDS36897.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000019526	VEGA Gene Model \| MGI Sequence Detail	7150	C57BL/6J	± kb
transcript	OTTMUST00000046636	VEGA \| MGI Sequence Detail	2064	Not Applicable
polypeptide	OTTMUSP00000021065	VEGA \| MGI Sequence Detail	408	Not Applicable

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SNPs within 2kb

75 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000000165 BMP4
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal

IPR001111 Transforming growth factor-beta, N-terminal

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All nucleic 136

Genomic 1

cDNA 56

Primer pair 21

Other 58

Microarray probesets 4

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MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602

Summaries

All 1110

Developmental Gene Expression 927

Diseases 4

Gene Ontology 97

Phenotypes 133
Earliest

J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
Latest

J:233686 Jia WJ, et al., Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation. Am J Pathol. 2016 Jun;186(6):1454-65

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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