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Bmp4 Gene Detail
Summary
  • Symbol
    Bmp4
  • Name
    bone morphogenetic protein 4
  • Synonyms
    Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88180
    NCBI Gene: 12159
  • Gene Overview
    MyGene.info: BMP4
Location & Maps
more
  • Sequence Map
    Chr14:46383520-46390669 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7150 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 23.95 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
    Orthology source: HomoloGene
  • Synonyms
    BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
  • Links
    NCBI Gene ID: 652
    neXtProt AC: NX_P12644

  • Chr Location
    14q22-q23; chr14:53949736-53956836 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Bmp4 mouse models; 2 with human BMP4 associations

Human Disease Mouse Models
       Atrioventricular Septal Defect; AVSD   OMIM: 606215 View 2 models
Axenfeld-Rieger Syndrome, Type 3; RIEG3   OMIM: 602482 View 1 model
Fibrodysplasia Ossificans Progressiva; FOP   OMIM: 135100 View 1 model
       Microphthalmia, Syndromic 6; MCOPS6   OMIM: 607932
Orofacial Cleft 11; OFC11   OMIM: 600625
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    216 phenotypes from 14 alleles in 33 genetic backgrounds
    132 phenotypes from multigenic genotypes
    10 images
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    19
  • Transgenic
    4
  • Genomic Mutations
    1 involving Bmp4
  • Incidental Mutations
Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019526 VEGA Gene Model | MGI Sequence Detail 7150 C57BL/6J ±  kb
transcript OTTMUST00000046636 VEGA | MGI Sequence Detail 2064 Not Applicable  
polypeptide OTTMUSP00000021065 VEGA | MGI Sequence Detail 408 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
Molecular
Reagents
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  • All nucleic 134
    Genomic 1
    cDNA 56
    Primer pair 21
    Other 56

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602
References
more
  • Summaries
    All 1100
    Developmental Gene Expression 919
    Diseases 4
    Gene Ontology 95
    Phenotypes 132
  • Earliest
    J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
  • Latest
    J:229516 Qiu Z, et al., Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression. BMC Biol. 2016;14(1):18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory