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Bmp4
Gene Detail
Symbol

Name
ID
Bmp4
bone morphogenetic protein 4
MGI:88180
Synonyms
Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4
Feature Type
protein coding gene
Genetic Map
Chromosome 14
23.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr14:46383520-46390669 bp, - strand
From VEGA annotation of GRCm38

  7150 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp4

Human
homologs
Human Homolog BMP4, bone morphogenetic protein 4
NCBI Gene ID 652
neXtProt AC  NX_P12644
Human Synonyms  BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
Human Chr (Location)  14q22-q23; chr14:53949736-53956836 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human BMP4
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(8) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
 
Human Diseases Modeled Using Mouse Bmp4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)
Interactions
Bmp4 interacts with 50 markers (Mir17, Mir20a, Mir106b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (854 records)
Data Summary: Results (1508)    Tissues (716)    Images (530)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 1258
In situ reporter (knock in) 109
Northern blot 22
Western blot 6
RT-PCR 94
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) Genomic(1) cDNA(56) Primer pair(20) Other(50)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019526 (Evidence)
Ensembl Gene ModelENSMUSG00000021835 (Evidence)
Entrez Gene12159 (Evidence)
DFCITC1584053, TC1596765, TC1747376
DoTSDT.522369
Consensus CDS ProjectCCDS36897.1
International Mouse Knockout Project StatusBmp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019526 VEGA Gene Model | MGI Sequence Detail 7150 C57BL/6J ±  kb
transcript OTTMUST00000046636 VEGA | MGI Sequence Detail 2064 Not Applicable 
polypeptide OTTMUSP00000021065 VEGA | MGI Sequence Detail 408 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000165 BMP4
References
(Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:214083 Boucherat O, et al., Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development. 2014 Aug;141(16):3197-211
All references(1034)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory