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App Gene Detail
Summary
  • Symbol
    App
  • Name
    amyloid beta (A4) precursor protein
  • Synonyms
    Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88059
    NCBI Gene: 11820
  • Gene Overview
    MyGene.info: APP
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84952666-85173952 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3-qter
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1767 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88059
protein coding gene Chr16:84949685-85173952 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022971
protein coding gene Chr16:85538293-85779069 (-)
A/J MGP_AJ_G0022939
protein coding gene Chr16:81635763-81870958 (-)
AKR/J MGP_AKRJ_G0022909
protein coding gene Chr16:84052258-84275218 (-)
BALB/cJ MGP_BALBcJ_G0022941
protein coding gene Chr16:82102186-82329050 (-)
C3H/HeJ MGP_C3HHeJ_G0022703
protein coding gene Chr16:84626584-84862447 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023388
protein coding gene Chr16:88329505-88563855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020892
protein coding gene Chr16:79584787-79800532 (-)
CAST/EiJ MGP_CASTEiJ_G0022225
protein coding gene Chr16:85065533-85300272 (-)
CBA/J MGP_CBAJ_G0022672
protein coding gene Chr16:92094150-92353190 (-)
DBA/2J MGP_DBA2J_G0022806
protein coding gene Chr16:81522782-81750538 (-)
FVB/NJ MGP_FVBNJ_G0022781
protein coding gene Chr16:80720282-80944609 (-)
LP/J MGP_LPJ_G0022875
protein coding gene Chr16:85225009-85479769 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022800
protein coding gene Chr16:96545311-96787683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023406
protein coding gene Chr16:84540160-84778677 (-)
PWK/PhJ MGP_PWKPhJ_G0021967
protein coding gene Chr16:81688476-81912234 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021797
protein coding gene Chr16:84020150-84249618 (-)
WSB/EiJ MGP_WSBEiJ_G0022273
protein coding gene Chr16:84776988-85012923 (-)



Homology
more
  • Human Ortholog
    APP, amyloid beta precursor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APP, amyloid beta precursor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II, preA4
  • Links
    NCBI Gene ID: 351
    neXtProt AC: NX_P05067
    UniProt: P05067

  • Chr Location
    21q21.3; chr21:25880550-26171128 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56379
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APP
  • Gene Tree
    App
Human Diseases
more
  • Diseases
    1 with App mouse models; 2 with human APP associations

Human Disease Mouse Models
      
IDs
View 111 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    53 with disease annotations
  • References
    99 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    87 phenotypes from 32 alleles in 28 genetic backgrounds
    280 phenotypes from multigenic genotypes
    12 images
    2474 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11820 NCBI Gene Model | MGI Sequence Detail 221287 C57BL/6J ±  kb
    transcript NM_001198823 RefSeq | MGI Sequence Detail 3377 C57BL/6  
    polypeptide P12023 UniProt | EBI | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000004168 amyloid-beta A4 protein
    • PDB
    • InterPro Domains
      IPR028866 Amyloid beta A4 protein
      IPR008155 Amyloidogenic glycoprotein
      IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
      IPR037071 Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR011993 PH-like domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    Molecular
    Reagents
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    • All nucleic 42
      Genomic 4
      cDNA 32
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007
    References
    more
    • Summaries
      All 2796
      Developmental Gene Expression 46
      Diseases 99
      Gene Ontology 66
      Phenotypes 2474
    • Earliest
      J:31044 McAdam KP, et al., Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. Int J Lepr Other Mycobact Dis. 1977 Apr-Jun;45(2):150-7
    • Latest
      J:266414 Rangasamy SB, et al., Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. J Clin Invest. 2018 Oct 1;128(10):4297-4312

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory