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App Gene Detail
Summary
  • Symbol
    App
  • Name
    amyloid beta (A4) precursor protein
  • Synonyms
    Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88059
    NCBI Gene: 11820
  • Gene Overview
    MyGene.info: APP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:84952666-85173952 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      221287 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3-qter
  • Mapping Data
    48 experiments
Homology
more
  • Human Ortholog
    APP, amyloid beta precursor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APP, amyloid beta precursor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II, preA4
  • Links
    NCBI Gene ID: 351
    neXtProt AC: NX_P05067
    UniProt: P05067

  • Chr Location
    21q21.3; chr21:25880550-26171128 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56379
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APP
  • Gene Tree
    App
Human Diseases
more
  • Diseases
    1 with App mouse models; 2 with human APP associations

Human Disease Mouse Models
      
IDs
View 111 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    53 with disease annotations
  • References
    99 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    87 phenotypes from 32 alleles in 27 genetic backgrounds
    278 phenotypes from multigenic genotypes
    12 images
    2348 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11820 NCBI Gene Model | MGI Sequence Detail 221287 C57BL/6J ±  kb
    transcript NM_001198823 RefSeq | MGI Sequence Detail 3377 C57BL/6  
    polypeptide P12023 UniProt | EBI | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1767 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000004168 amyloid-beta A4 protein
    • PDB
    • InterPro Domains
      IPR028866 Amyloid beta A4 protein
      IPR008155 Amyloidogenic glycoprotein
      IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
      IPR037071 Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR011993 PH-like domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    Molecular
    Reagents
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    • All nucleic 41
      Genomic 4
      cDNA 31
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007
    References
    more
    • Summaries
      All 2665
      Developmental Gene Expression 44
      Diseases 99
      Gene Ontology 62
      Phenotypes 2348
    • Earliest
      J:31044 McAdam KP, et al., Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. Int J Lepr Other Mycobact Dis. 1977 Apr-Jun;45(2):150-7
    • Latest
      J:261269 Martinez-Losa M, et al., Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 Apr 4;98(1):75-89.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory