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App
Gene Detail
 Symbol
Name
ID
App
amyloid beta (A4) precursor protein
MGI:88059
Synonyms Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II
Feature Type protein coding gene
Genetic Map
Chromosome 16
46.92 cM, cytoband C3-qter
Detailed Genetic Map ± 1 cM


Mapping data(48)
Sequence Map
Chr16:84954440-85173707 bp, - strand
From Ensembl annotation of GRCm38

  219268 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56379  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: App

Human
homologs
Human Homolog APP, amyloid beta (A4) precursor protein
NCBI Gene ID 351
neXtProt AC  NX_P05067
Human Synonyms  AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II
Human Chr (Location)  21q21.3; chr21:25880550-26171128 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human APP
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Targeted(25)
Genomic Mutations involving App (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.
 
Human Diseases Modeled Using Mouse App (1)    Alleles Annotated to Human Diseases(5)    Phenotype Images(2)
Interactions
App interacts with 278 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (121 annotations)
Process adult locomotory behavior, apoptotic process, ...
Component apical part of cell, axon, ...
Function acetylcholine receptor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (227)    Tissues (180)    Images (21)
Theiler Stages: 11, 13, 15, 17, 20, 22, 25, 26, 28
Assay TypeResults
RNA in situ 185
RT-PCR 42
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(4) cDNA(31) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022892 (Evidence)
Entrez Gene11820 (Evidence)
DFCITC1573751, TC1598258, TC1601541, TC1603938
DoTSDT.101190035, DT.101226146, DT.101246287, DT.101287752, DT.102548873, DT.103577624, DT.110737942, DT.91330139, DT.94144862, DT.94144936, DT.94312819, DT.94344131, DT.97368194, DT.97390493, DT.97390518, DT.97390521, DT.99867790
NIA Mouse Gene IndexU037237, U188913, U376466
PDB2ROZ, 2YSZ, 2YT0, 2YT1
Consensus CDS ProjectCCDS28285.1
International Mouse Knockout Project StatusApp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022892 Ensembl Gene Model | MGI Sequence Detail 219268 C57BL/6J ±  kb
transcript ENSMUST00000005406 Ensembl | MGI Sequence Detail 3128 Not Applicable 
polypeptide ENSMUSP00000005406 Ensembl | MGI Sequence Detail 695 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(14) UniProt(8)
Polymorphisms All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(1769 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1771)
Protein-related
information
ResourceIDDescription
InterPro IPR008155 Amyloidogenic glycoprotein
InterPro IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
InterPro IPR011178 Amyloidogenic glycoprotein, copper-binding
InterPro IPR024329 Amyloidogenic glycoprotein, E2 domain
InterPro IPR008154 Amyloidogenic glycoprotein, extracellular
InterPro IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
InterPro IPR015849 Amyloidogenic glycoprotein, heparin-binding
InterPro IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
InterPro IPR019543 Beta-amyloid precursor protein C-terminal
InterPro IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
Protein Ontology PR:000004168 amyloid beta A4 protein
References (Earliest) J:31044 McAdam KP, et al., Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. Int J Lepr Other Mycobact Dis. 1977 Apr-Jun;45(2):150-7
(Latest) J:211049 Olsen O, et al., Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of beta-secretase. J Neurosci. 2014 May 7;34(19):6438-47
All references(433)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory