About   Help   FAQ
App Gene Detail
Summary
  • Symbol
    App
  • Name
    amyloid beta (A4) precursor protein
  • Synonyms
    Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88059
    NCBI Gene: 11820
  • Gene Overview
    MyGene.info: APP
Location & Maps
more
  • Sequence Map
    Chr16:84954440-85173707 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      219268 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    APP, amyloid beta precursor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APP, amyloid beta precursor protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II
  • Links
    NCBI Gene ID: 351
    neXtProt AC: NX_P05067

  • Chr Location
    21q21.3; chr21:25880550-26171128 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56379
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: APP
  • Gene Tree
    App
Human Diseases
more
  • Diseases
    1 with App mouse models; 2 with human APP associations

Human Disease Mouse Models
       Alzheimer Disease; AD   OMIM: 104300 View 108 models
       Cerebral Amyloid Angiopathy, App-Related   OMIM: 605714 View 10 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    51 with disease annotations
  • References
    424 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 29 alleles in 23 genetic backgrounds
    260 phenotypes from multigenic genotypes
    4 images
    1946 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    106
  • Targeted
    31
  • Transgenic
    75
  • Genomic Mutations
    4 involving App
  • Incidental Mutations
Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022892 Ensembl Gene Model | MGI Sequence Detail 219268 C57BL/6J ±  kb
transcript ENSMUST00000005406 Ensembl | MGI Sequence Detail 3128 Not Applicable  
polypeptide ENSMUSP00000005406 Ensembl | MGI Sequence Detail 695 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1760 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000004168 amyloid beta A4 protein
  • PDB
  • InterPro Domains
    IPR028866 Amyloid beta A4 protein
    IPR008155 Amyloidogenic glycoprotein
    IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
    IPR011178 Amyloidogenic glycoprotein, copper-binding
    IPR024329 Amyloidogenic glycoprotein, E2 domain
    IPR008154 Amyloidogenic glycoprotein, extracellular
    IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
    IPR015849 Amyloidogenic glycoprotein, heparin-binding
    IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
    IPR019543 Beta-amyloid precursor protein C-terminal
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Molecular
Reagents
less
  • All nucleic 41
    Genomic 4
    cDNA 31
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007
References
more
  • Summaries
    All 455
    Developmental Gene Expression 39
    Diseases 424
    Gene Ontology 58
    Phenotypes 1946
  • Earliest
    J:31044 McAdam KP, et al., Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. Int J Lepr Other Mycobact Dis. 1977 Apr-Jun;45(2):150-7
  • Latest
    J:230660 Kuhn PH, et al., Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory