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App Gene Detail
Summary
  • Symbol
    App
  • Name
    amyloid beta precursor protein
  • Synonyms
    Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88059
    NCBI Gene: 11820
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84751236-84972187 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3-qter
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1766 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88059
 protein coding gene Chr16:84746573-84972187 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022971
 protein coding gene Chr16:85538293-85779069 (-)
A/J MGP_AJ_G0022939
 protein coding gene Chr16:81635763-81870958 (-)
AKR/J MGP_AKRJ_G0022909
 protein coding gene Chr16:84052258-84275218 (-)
BALB/cJ MGP_BALBcJ_G0022941
 protein coding gene Chr16:82102186-82329050 (-)
C3H/HeJ MGP_C3HHeJ_G0022703
 protein coding gene Chr16:84626584-84862447 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023388
 protein coding gene Chr16:88329505-88563855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020892
 protein coding gene Chr16:79584787-79800532 (-)
CAST/EiJ MGP_CASTEiJ_G0022225
 protein coding gene Chr16:85065533-85300272 (-)
CBA/J MGP_CBAJ_G0022672
 protein coding gene Chr16:92094150-92353190 (-)
DBA/2J MGP_DBA2J_G0022806
 protein coding gene Chr16:81522782-81750538 (-)
FVB/NJ MGP_FVBNJ_G0022781
 protein coding gene Chr16:80720282-80944609 (-)
LP/J MGP_LPJ_G0022875
 protein coding gene Chr16:85225009-85479769 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022800
 protein coding gene Chr16:96545311-96787683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023406
 protein coding gene Chr16:84540160-84778677 (-)
PWK/PhJ MGP_PWKPhJ_G0021967
 protein coding gene Chr16:81688476-81912234 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021797
 protein coding gene Chr16:84020150-84249618 (-)
WSB/EiJ MGP_WSBEiJ_G0022273
 protein coding gene Chr16:84776988-85012923 (-)



Homology
more
  • Human Ortholog
    APP, amyloid beta precursor protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APP, amyloid beta precursor protein
  • Synonyms
    AAA, ABETA, ABPP, AD1, alpha-sAPP, APPI, CTFgamma, CVAP, PN2, PN-II, preA4
  • Links
    NCBI Gene ID: 351
    neXtProt AC: NX_P05067
    UniProt: P05067

  • Chr Location
    21q21.3; chr21:25880535-26171128 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with App mouse models; 6 with human APP associations

Human Disease Mouse Models
      
IDs
 View 24 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    23 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    91 phenotypes from 31 alleles in 28 genetic backgrounds
    100 phenotypes from multigenic genotypes
    3 images
    1394 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    326
  • GO References
    81
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1097
  • Tissues
    269
  • cDNA Data
    26
  • Literature Summary
    58
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11820 NCBI Gene Model | MGI Sequence Detail 220952 C57BL/6J ±  kb
    transcript NM_001198823 RefSeq | MGI Sequence Detail 3377 ZRU/MplStud  
    polypeptide P12023 UniProt | EBI | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000004168 amyloid-beta precursor protein
      (term hierarchy)
    • PDB
      2ROZ, 2YSZ, 2YT0, 2YT1, 4YN0, 5MYK, 7MRN, 8BG9
    • InterPro Domains
      IPR008155 Amyloidogenic glycoprotein
      IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptide
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved site
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR011993 PH-like domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 4
      cDNA 33
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007
    References
    more
    • Summaries
      All 2041
      Developmental Gene Expression 58
      Diseases 23
      Gene Ontology 81
      Phenotypes 1394
    • Earliest
      J:31044 McAdam KP, et al., Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. Int J Lepr Other Mycobact Dis. 1977 Apr-Jun;45(2):150-7
    • Latest
      J:346660 Zelek WM, et al., Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia. Brain Behav Immun. 2024 Mar 12;118:355-363
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory