App
Gene Detail

Symbol Name ID

App amyloid beta (A4) precursor protein MGI:88059

Synonyms

Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II

Feature Type

protein coding gene

Genetic Map

Chromosome 16

46.92 cM, cytoband C3-qter
Detailed Genetic Map ± 1 cM


Mapping data(48)

Sequence Map

Chr16:84954440-85173707 bp, - strand From Ensembl annotation of GRCm38   219268 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:131156  Vertebrate Homology Class
1 human; 1 mouse; 1 zebrafish

Gene Tree: App

Human homologs

Human Homolog		APP, amyloid beta (A4) precursor protein
NCBI Gene ID		351
neXtProt AC		NX_P05067
Human Synonyms		AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II
Human Chr (Location)		21q21.3; chr21:27252861-27543446 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human APP

Alleles and phenotypes

All alleles(22) : Targeted(22)
 

Mice homozygous for disruptions in this gene exhibit reduced body weight, brain weight, size of forebrain commissures, locomotor activity, forelimb grip strength, and spatial learning scores. Many mice also exhibit agenesis of the corpus callosum, and extensive reactive gliosis.

 
Human Diseases Modeled Using Mouse App (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (96 annotations)

Process	adult locomotory behavior, apoptotic process, ...
Component	apical part of cell, axon, ...
Function	acetylcholine receptor binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (201)    Tissues (154)    Images (20)
Theiler Stages: 11, 13, 15, 17, 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	159
RT-PCR	42

cDNA source data(698)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(715) Genomic(4) cDNA(705) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022892 (Evidence)
Entrez Gene	11820 (Evidence)
UniGene	277585
DFCI	TC1573751, TC1598258, TC1601541, TC1603938
DoTS	DT.101190035, DT.101226146, DT.101287752, DT.102548873, DT.103577624, DT.110737942, DT.91330139, DT.94144862, DT.94144936, DT.94312819, DT.94344131, DT.97368194, DT.97390493, DT.97390518, DT.97390521, DT.99867790
NIA Mouse Gene Index	U037237, U188913, U376466
PDB	2ROZ, 2YSZ, 2YT0, 2YT1
Consensus CDS Project	CCDS28285.1
International Mouse Knockout Project Status	App

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022892	Ensembl Gene Model | MGI Sequence Detail	219268	C57BL/6J
transcript	ENSMUST00000005406	Ensembl | MGI Sequence Detail	3128	Not Applicable
polypeptide	ENSMUSP00000005406	Ensembl | MGI Sequence Detail	695	Not Applicable

All sequences(102) RefSeq(10) UniProt(8)

Polymorphisms

All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs(1328 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008155	Amyloidogenic glycoprotein
InterPro	IPR013803	Amyloidogenic glycoprotein, amyloid-beta peptide
InterPro	IPR011178	Amyloidogenic glycoprotein, copper-binding
InterPro	IPR024329	Amyloidogenic glycoprotein, E2 domain
InterPro	IPR008154	Amyloidogenic glycoprotein, extracellular
InterPro	IPR019744	Amyloidogenic glycoprotein, extracellular domain conserved site
InterPro	IPR015849	Amyloidogenic glycoprotein, heparin-binding
InterPro	IPR019745	Amyloidogenic glycoprotein, intracellular domain, conserved site
InterPro	IPR019543	Beta-amyloid precursor protein C-terminal
InterPro	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site
InterPro	IPR002223	Proteinase inhibitor I2, Kunitz metazoa
Protein Ontology	PR:000004168	amyloid beta A4 protein
Protein Ontology	PR:000025533	amyloid beta A4 protein (mouse)

References

(Earliest) J:31044 McAdam KP, et al., Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. Int J Lepr Other Mycobact Dis. 1977 Apr-Jun;45(2):150-7
(Latest) J:191360 Morales-Corraliza J, et al., Immunization targeting a minor plaque constituent clears beta-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiol Aging. 2013 Jan;34(1):137-45
All references(404)

Other accession IDs

MGD-MRK-1105, MGD-MRK-1378, MGD-MRK-2255, MGI:2146529, MGI:2442007