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Phenotypes Associated with This Genotype
Genotype
MGI:5008418
Allelic
Composition
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background
B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPswe,PSEN1dE9)85Dbo mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Beta-amyloid plaques in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and neurofibrillary tangles in Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/0 mice

mortality/aging
• about 40% of mice are lost by 12 months of age (J:160557)
• mice exhibit reduced lifespan, with survival rate beginning to decline at approximately 8 weeks of age and only approximately 40% of mice survive to 45 weeks (J:360724)

behavior/neurological
• mice exhibit reduced retention times in the passive avoidance test, indicating reduced memory, however acquisition times are not affected (J:360724)
• mice treated with an anti-FAM195A antibody at 8 months of age show improved memory retention in the passive avoidance test (J:360724)
• mice exhibit decreased freezing to context
• 4 month old mice infused with the specific PTEN inhibitor VO-OHpic into the brain ventricles over a period for 3-4 weeks show improvement in contextual conditioning behavior
• 4 month old mice infused with a cell-permeable PTEN-PDZ peptide over a period of 3-4 weeks into the brain ventricles show improvement in the contextual fear conditioning tests
• however, VO-OHpic treatment does not affect auditory-cued fear conditioning (hippocampal-independent task), exploratory activity or basal freezing behavior
• severely impaired performance in a morris water maze with much longer latencies to reach a hidden platform (J:160557)
• performance in a morris water maze declines between 3 and 12 months of age (J:160557)
• 6 month old mutants exhibit slower visuospatial learning than control mice (J:172426)
• in the visuospatial re-learning test performed at 9, 11, 13, 15, and 18 months of age, mutants exhibit a decrease in the speed of re-learning the task compared to controls (J:172426)
• mice exhibit impaired behavior in the novel object location task
• 4 month old mice infused with the specific PTEN inhibitor VO-OHpic into the brain ventricles over a period for 3-4 weeks show improvement in spatial learning tasks
• 4 month old mice infused with a cell-permeable PTEN-PDZ peptide over a period of 3-4 weeks into the brain ventricles show improvement in the novel object-location task
• mice exhibit reduced spontaneous alternation in the Y-maze
• mice administered an anti-FAM19A5 antibody intravenously at 8 months of age show increased spontaneous alternation and thus improved performance in the Y-maze test
• Background Sensitivity: premature death early in life eappears to result from convulsive seizures and is much less frequent on the C57BL/6J background than on the DBA/2J background

nervous system
• Background Sensitivity: premature death early in life eappears to result from convulsive seizures and is much less frequent on the C57BL/6J background than on the DBA/2J background
• Background Sensitivity: there are more ThioS+ plaques in the cortex on the C57BL/6J background than on the DBA/2J background (J:227541)
• mice develop amyloid beta plaques in the cortex and hippocampus (J:360724)
• mice administered an anti-FAM19A5 antibody intravenously at 8 months of age show a trend toward decreased amyloid beta oligomer and plaque levels that does not reach significance (J:360724)
• at 2 months of age carriers are indistinguishable from C57BL/6J controls, but at 4 months of age very small plaques are found in the cortex, and at 6 months of age plaques are evident in the cortex and hippocampus (J:208080)
• axon degeneration and synapse loss
• basal synaptic transmission is lower in hippocampal slices
• VO-OHpic treatment does not rescue the lower basal synaptic transmission
• semi-chronic treatment with VO-OHpic fully rescues LTP levels in hippocampal slices

taste/olfaction
N
• mutants do not exhibit Alzheimer's disease-related impairments in olfactory performance in tests based on an operant conditioning procedure and in tests based on a habituation/dishabituation procedure

homeostasis/metabolism
• Background Sensitivity: there are more ThioS+ plaques in the cortex on the C57BL/6J background than on the DBA/2J background (J:227541)
• mice develop amyloid beta plaques in the cortex and hippocampus (J:360724)
• mice administered an anti-FAM19A5 antibody intravenously at 8 months of age show a trend toward decreased amyloid beta oligomer and plaque levels that does not reach significance (J:360724)
• at 2 months of age carriers are indistinguishable from C57BL/6J controls, but at 4 months of age very small plaques are found in the cortex, and at 6 months of age plaques are evident in the cortex and hippocampus (J:208080)

cellular

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:160557 , J:172426 , J:234430 , J:360724


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory