App^tm1Ck
Targeted Allele Detail

Summary

• Symbol: App^tm1Ck
• Name: amyloid beta precursor protein; targeted mutation 1, Christoph Kohler
• MGI ID: MGI:3609234
• Synonyms: APP/hAbeta, APP-SL, APP^sl/Abeta
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1Ck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102542
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed such that the locus contains the Swedish/London-FAD mutation and a "humanized" Abeta domain sequence in exons 16-18 under the control of the endogenouse APP promoter. A pA sequence and neomycin resistance gene was included in the vector. (J:102542)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 89 strains or lines available

Notes

ES cell line = G1 (Bayer), established from an unspecified 129 subline.

References

• Original: J:102542 Kohler C, et al., Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels. Neurobiol Dis. 2005 Nov;20(2):528-40
• All: 11 reference(s)