Analysis Tools
homeostasis/metabolism
|
• Background Sensitivity: although hemizygotes do have some ThioS+ plaque deposition in the cortex, there are far fewer plaques than are found in hemizygotes on the C57BL/6J background (average 10 per section versus 58 per section)
|
hematopoietic system
microgliosis
(
J:227541
)
|
• cortical staining finds a slight increase in microglia in hemizygotes compared with DBA/2J controls
|
mortality/aging
|
• Background Sensitivity: There is a much higher rate of premature death in hemizygotes on the DBA/2J background than on the C57BL/6J background, although hemizygotes that survive beyond 6 months of age do not have a high rate of premature death thereafter
|
immune system
microgliosis
(
J:227541
)
|
• cortical staining finds a slight increase in microglia in hemizygotes compared with DBA/2J controls
|
behavior/neurological
|
• Background Sensitivity: on the DBA/2J background hemizygotes that die prematurely are found in a lethal seizure pose of clenched front limbs and stretched out hind limbs consistent with the audiogenic seizure-induced death inherent in DBA/2J, but the percentage of hemizygotes found dead is much higher than that in wild type DBA/2J. Consistent with wild-type DBA/2J lethal seizures, premature death is not found in hemizygotes that survive beyond 6 months of age.
• despite the increased lethal seizures, the electroconvulsive threshold is not decreased relative to DBA/2J controls
|
nervous system
| N |
• no significant differences are found between hemizygotes and DBA/2J in neuron number in the three different regions of the cortex at 6 months of age, indicating no increase in neuronal cell loss, and the number of cortical astrocytes is normal
|
|
• Background Sensitivity: on the DBA/2J background hemizygotes that die prematurely are found in a lethal seizure pose of clenched front limbs and stretched out hind limbs consistent with the audiogenic seizure-induced death inherent in DBA/2J, but the percentage of hemizygotes found dead is much higher than that in wild type DBA/2J. Consistent with wild-type DBA/2J lethal seizures, premature death is not found in hemizygotes that survive beyond 6 months of age.
• despite the increased lethal seizures, the electroconvulsive threshold is not decreased relative to DBA/2J controls
|
microgliosis
(
J:227541
)
|
• cortical staining finds a slight increase in microglia in hemizygotes compared with DBA/2J controls
|
|
• Background Sensitivity: although hemizygotes do have some ThioS+ plaque deposition in the cortex, there are far fewer plaques than are found in hemizygotes on the C57BL/6J background (average 10 per section versus 58 per section)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:227541 | ||
