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Akt1
Gene Detail
Symbol

Name
ID
Akt1
thymoma viral proto-oncogene 1
MGI:87986
Synonyms
Akt, PKB, PKB/Akt, PKBalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.20 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:112653821-112674884 bp, - strand
From VEGA annotation of GRCm38

  21064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AKT1
Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt1

Human
homologs
AKT1, v-akt murine thymoma viral oncogene homolog 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 207
neXtProt AC: NX_P31749

Human Synonyms: AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA

Human Chr (Location): 14q32.32; chr14:104769349-104795743 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human AKT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(4) Targeted(12) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes are smaller than sibs due to retarded prenatal and postnatal growth and exhibit increased apoptosis and decreased lifespan with genotoxic stress. Mice are fertile, but males have attenuated spermatogenesis and abnormal testes.
 
Human Diseases Modeled in Mice Using Akt1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(3)
Interactions
Akt1 interacts with 130 markers (Mir7-1, Mir15a, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (169 annotations)
Process activation-induced cell death of T cells, aging, ...
Component cell-cell junction, ciliary basal body, ...
Function 14-3-3 protein binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (197 records)
Data Summary: Results (266)    Tissues (116)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 67
Western blot 86
RT-PCR 94
cDNA source data(221)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase akt1 ; ZFIN akt1    NEW 
Molecular
reagents
All nucleic(229) Genomic(2) cDNA(221) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020941 (Evidence)
Ensembl Gene Model ENSMUSG00000001729 (Evidence)
Entrez Gene 11651 (Evidence)
UniGene 6645
DFCI TC1574276, TC1582836, TC1596841, TC1668174
DoTS DT.101403566, DT.535357, DT.94188038, DT.94396697
NIA Mouse Gene Index U034387
EC 2.7.11.1
Consensus CDS Project CCDS26194.1
International Mouse Phenotyping Consortium Status Akt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020941 VEGA Gene Model | MGI Sequence Detail 21064 C57BL/6J ±  kb
transcript OTTMUST00000049495 VEGA | MGI Sequence Detail 2690 Not Applicable 
polypeptide OTTMUSP00000022944 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002190 RAC-alpha serine/threonine-protein kinase
References
(Earliest) J:455 Cho M, et al., A linkage map of distal mouse chromosome 12. Mamm Genome. 1991;1(1):30-6
(Latest) J:221495 Tapia O, et al., Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015;10(3):e0116196
All references(583)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory