Akt1
Gene Detail

Symbol Name ID

Akt1 thymoma viral proto-oncogene 1 MGI:87986

Synonyms

Akt, PKB, PKB/Akt, PKBalpha

Feature Type

protein coding gene

Genetic Map

Chromosome 12

61.20 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:112653821-112674884 bp, - strand From VEGA annotation of GRCm38   21064 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt1

Human homologs

Human Homolog		AKT1, v-akt murine thymoma viral oncogene homolog 1
NCBI Gene ID		207
neXtProt AC		NX_P31749
Human Synonyms		AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Human Chr (Location)		14q32.32; chr14:105235686-105262080 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human AKT1

Alleles and phenotypes

All alleles(13) : Targeted(9) Gene trapped(4)
 

Mutant homozygotes are smaller than sibs due to retarded prenatal and postnatal growth and exhibit increased apoptosis and decreased lifespan with genotoxic stress. Mice are fertile, but males have attenuated spermatogenesis and abnormal testes.

 
Human Diseases Modeled Using Mouse Akt1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (142 annotations)

Process	activation-induced cell death of T cells, aging, ...
Component	cytoplasm, cytosol, ...
Function	14-3-3 protein binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (159 records)
Data Summary: Results (244)    Tissues (105)    Images (33)
Theiler Stages: 2, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	67
Western blot	66
RT-PCR	94

cDNA source data(217)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(225) Genomic(2) cDNA(217) Primer pair(5) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020941 (Evidence)
Ensembl Gene Model	ENSMUSG00000001729 (Evidence)
Entrez Gene	11651 (Evidence)
UniGene	6645
DFCI	TC1574276, TC1582836, TC1596841, TC1668174
DoTS	DT.101403566, DT.535357, DT.94188038, DT.94396697
NIA Mouse Gene Index	U034387
EC	2.7.11.1
Consensus CDS Project	CCDS26194.1
International Mouse Knockout Project Status	Akt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020941	VEGA Gene Model | MGI Sequence Detail	21064	C57BL/6J
transcript	OTTMUST00000049495	VEGA | MGI Sequence Detail	2690	Not Applicable
polypeptide	OTTMUSP00000022944	VEGA | MGI Sequence Detail	480	Not Applicable

All sequences(63) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000002190	RAC-alpha serine/threonine-protein kinase

References

(Earliest) J:455 Cho M, et al., A linkage map of distal mouse chromosome 12. Mamm Genome. 1991;1(1):30-6
(Latest) J:196196 Awuah PK, et al., Role and Regulation of PDGFRalpha Signaling in Liver Development and Regeneration. Am J Pathol. 2013 May;182(5):1648-58
All references(478)

Other accession IDs

MGD-MRK-1257