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Akt1
Gene Detail
 Symbol
Name
ID
Akt1
thymoma viral proto-oncogene 1
MGI:87986
Synonyms Akt, PKB, PKB/Akt, PKBalpha
Feature Type protein coding gene
Genetic Map
Chromosome 12
61.20 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:112653821-112674884 bp, - strand
From VEGA annotation of GRCm38

  21064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3785  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt1

Human
homologs
Human Homolog AKT1, v-akt murine thymoma viral oncogene homolog 1
NCBI Gene ID 207
neXtProt AC  NX_P31749
Human Synonyms  AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Human Chr (Location)  14q32.32; chr14:104769349-104795743 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human AKT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(4) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes are smaller than sibs due to retarded prenatal and postnatal growth and exhibit increased apoptosis and decreased lifespan with genotoxic stress. Mice are fertile, but males have attenuated spermatogenesis and abnormal testes.
 
Human Diseases Modeled Using Mouse Akt1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Akt1 interacts with 130 markers (Mir7-1, Mir15a, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (157 annotations)
Process activation-induced cell death of T cells, aging, ...
Component cell-cell junction, ciliary basal body, ...
Function 14-3-3 protein binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (181 records)
Data Summary: Results (246)    Tissues (106)    Images (35)
Theiler Stages: 2, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 19
RNA in situ 67
Western blot 66
RT-PCR 94
cDNA source data(221)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(229) Genomic(2) cDNA(221) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020941 (Evidence)
Ensembl Gene ModelENSMUSG00000001729 (Evidence)
Entrez Gene11651 (Evidence)
UniGene6645
DFCITC1574276, TC1582836, TC1596841, TC1668174
DoTSDT.101403566, DT.535357, DT.94188038, DT.94396697
NIA Mouse Gene IndexU034387
EC2.7.11.1
Consensus CDS ProjectCCDS26194.1
International Mouse Knockout Project StatusAkt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020941 VEGA Gene Model | MGI Sequence Detail 21064 C57BL/6J ±  kb
transcript OTTMUST00000049495 VEGA | MGI Sequence Detail 2690 Not Applicable 
polypeptide OTTMUSP00000022944 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002190 RAC-alpha serine/threonine-protein kinase
References (Earliest) J:455 Cho M, et al., A linkage map of distal mouse chromosome 12. Mamm Genome. 1991;1(1):30-6
(Latest) J:210641 Lee G, et al., Akt-ivation of RNA splicing. Mol Cell. 2014 Feb 20;53(4):519-20
All references(528)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory