Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein kinase binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; regulation of gene expression; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to lipid; and embryonic placenta development. Located in several cellular components, including cell-cell junction; microtubule cytoskeleton; and mitochondrion. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Used to study Proteus syndrome and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); colorectal cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1).