Phenotypes Associated with This Genotype

Genotype
MGI:6460379

• Allelic Composition: Akt1^tm1.1Mjl/Akt1⁺
• Genetic Background: chimera involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:293971 )

• vascular malformations are seen in lymph nodes, adipose tissue, spleen, and/or other locations

• visible vascular malformations appear as dark, blood-filled, often multi-lobulated cystic masses

• vascular malformations are characterized as venous-capillary mixed-type malformations with ectatic channels and often containing a lymphatic component and no atypia

• numerous, variably-sized, thin-walled ectatic vessels, often separated by increased stroma are seen in these lesions

• vascular malformations in adipose tissue are comprised of multiple thin-walled vessels

endocrine/exocrine glands

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice

abnormal mammary gland duct morphology ( J:293971 )

• some mice exhibit mammary ductal ectasia

• 4 mice show unusual polypoid projections into mammary ducts that appear to be inversions of disorganized fatty and stromal tissue

mammary gland alveolar hyperplasia ( J:293971 )

• some mice exhibit alveolar hyperplasia

abnormal mammary gland stroma morphology ( J:293971 )

• some mice exhibit expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• some mice exhibit overgrowth of breast tissue

integument

abnormal mammary gland duct morphology ( J:293971 )

• some mice exhibit mammary ductal ectasia

• 4 mice show unusual polypoid projections into mammary ducts that appear to be inversions of disorganized fatty and stromal tissue

mammary gland alveolar hyperplasia ( J:293971 )

• some mice exhibit alveolar hyperplasia

abnormal mammary gland stroma morphology ( J:293971 )

• some mice exhibit expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• some mice exhibit overgrowth of breast tissue

epidermal hyperplasia ( J:293971 )

• one mice shows an area of epidermal hyperplasia similar to epidermal nevi

liver/biliary system

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice

growth/size/body

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Proteus syndrome		DOID:13482	OMIM:176920	J:293971