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Rhox Complex/Cluster/Region Detail
Summary
  • Symbol
    Rhox
  • Name
    reproductive homeobox cluster
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:5763243
  • Cluster Members
    Rhox1, Rhox2a, Rhox3a ... (41 members)
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome X, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele of the cluster exhibit a modest impact on testes size, male germ cell numbers and seminiferous tubule diameter.
References
more
  • Summaries
    All 4
    Phenotypes 3
  • Earliest
    J:229199 Song HW, et al., shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. PLoS One. 2015;10(3):e0118549
  • Latest
    J:306454 Tan K, et al., The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory