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Pde5a Gene Detail
Summary
  • Symbol
    Pde5a
  • Name
    phosphodiesterase 5A, cGMP-specific
  • Synonyms
    Pde5, PDE5A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651499
    NCBI Gene: 242202
Location & Maps
more
  • Sequence Map
    Chr3:122728947-122859374 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      130428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 53.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDE5A, phosphodiesterase 5A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE5A, phosphodiesterase 5A
    Orthology source: HomoloGene
  • Synonyms
    CGB-PDE, CN5A, PDE5
  • Links
    NCBI Gene ID: 8654
    neXtProt AC: NX_O76074

  • Chr Location
    4q27; chr4:119494395-119628826 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Pde5a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052456 VEGA Gene Model | MGI Sequence Detail 130428 C57BL/6J ±  kb
transcript OTTMUST00000131551 VEGA | MGI Sequence Detail 6939 Not Applicable  
polypeptide OTTMUSP00000070307 VEGA | MGI Sequence Detail 865 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1771 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 30
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 4
  • Earliest
    J:49444 Loughney K, et al., Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene. 1998 Aug 17;216(1):139-47
  • Latest
    J:210556 Mahavadi S, et al., Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G964-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory