About   Help   FAQ
Pde5a
Gene Detail
Symbol

Name
ID
Pde5a
phosphodiesterase 5A, cGMP-specific
MGI:2651499
Synonyms
Pde5, PDE5A1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
53.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:122728947-122859374 bp, + strand
From VEGA annotation of GRCm38

  130428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDE5A
Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase 5A
Gene Tree: Pde5a

Human
homologs
PDE5A, phosphodiesterase 5A, cGMP-specific
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8654
neXtProt AC: NX_O76074

Human Synonyms: CGB-PDE, CN5A, PDE5

Human Chr (Location): 4q27; chr4:119494395-119628826 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pde5a interacts with 411 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cGMP catabolic process, cGMP metabolic process, ...
Component cytosol
Function 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (188)    Tissues (95)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PDE5A ; Xenbase pde5a    NEW 
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000052456 (Evidence)
Ensembl Gene Model ENSMUSG00000053965 (Evidence)
Entrez Gene 242202 (Evidence)
UniGene 134911
NIA Mouse Gene Index U050798
EC 3.1.4.35
PDB 2K31
Consensus CDS Project CCDS17812.1
International Mouse Phenotyping Consortium Status Pde5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052456 VEGA Gene Model | MGI Sequence Detail 130428 C57BL/6J ±  kb
transcript OTTMUST00000131551 VEGA | MGI Sequence Detail 6939 Not Applicable 
polypeptide OTTMUSP00000070307 VEGA | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1780 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1782)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR029016 GAF domain-like
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012477 cGMP-specific 3',5'-cyclic phosphodiesterase
References
(Earliest) J:49444 Loughney K, et al., Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene. 1998 Aug 17;216(1):139-47
(Latest) J:210556 Mahavadi S, et al., Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G964-74
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory