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Pde5a
Gene Detail
Symbol

Name
ID
Pde5a
phosphodiesterase 5A, cGMP-specific
MGI:2651499
Synonyms
Pde5, PDE5A1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
53.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:122729158-122859374 bp, + strand
From NCBI annotation of GRCm38

  130217 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:842  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase 5A
Gene Tree: Pde5a

Human
homologs
Human Homolog PDE5A, phosphodiesterase 5A, cGMP-specific
NCBI Gene ID 8654
neXtProt AC  NX_O76074
Human Synonyms  CGB-PDE, CN5A, PDE5
Human Chr (Location)  4q27; chr4:119494395-119628826 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pde5a interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cGMP catabolic process, cGMP metabolic process, ...
Component cytosol
Function 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (188)    Tissues (95)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000053965 (Evidence)
Entrez Gene242202 (Evidence)
UniGene134911
NIA Mouse Gene IndexU050798
EC3.1.4.35
PDB2K31
Consensus CDS ProjectCCDS17812.1
International Mouse Knockout Project StatusPde5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 242202 NCBI Gene Model | MGI Sequence Detail 130217 C57BL/6J ±  kb
transcript NM_153422 RefSeq | MGI Sequence Detail 6728 C57BL/6 
polypeptide Q8CG03 UniProt | EBI | MGI Sequence Detail 865 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1779 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1781)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012477 cGMP-specific 3',5'-cyclic phosphodiesterase
Graphical View of Protein Domain Structure
References
(Earliest) J:49444 Loughney K, et al., Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene. 1998 Aug 17;216(1):139-47
(Latest) J:210556 Mahavadi S, et al., Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G964-74
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory