Fancd2
Gene Detail

Symbol Name ID

Fancd2 Fanconi anemia, complementation group D2 MGI:2448480

Synonyms

2410150O07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.78 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:113531682-113597017 bp, + strand From VEGA annotation of GRCm38   65336 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fancd2

Human homologs

Human Homolog		FANCD2, Fanconi anemia, complementation group D2
NCBI Gene ID		2177
neXtProt AC		NX_Q9BXW9
Human Synonyms		FA4, FACD, FAD, FAD2, FA-D2, FANCD
Human Chr (Location)		3p26; chr3:10068113-10143614 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FANCD2

Alleles and phenotypes

All alleles(30) : Targeted(3) Gene trapped(27)
 

Homozygous mutant mice exhibit defects observed in human patients with Fanconi anemia (FA) meiotic defects and germ cell loss. In addition, mutant mice display perinatal lethality, susceptiblity ot epithelial cancer, and microphthalmia.

 
Human Diseases Modeled Using Mouse Fancd2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell cycle, DNA repair, ...
Component	condensed chromosome, nucleus

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023488 (Evidence)
Ensembl Gene Model	ENSMUSG00000034023 (Evidence)
Entrez Gene	211651 (Evidence)
NIA Mouse Gene Index	U042764
PDB	3S4W
Consensus CDS Project	CCDS20426.1
International Mouse Knockout Project Status	Fancd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023488	VEGA Gene Model | MGI Sequence Detail	65336	C57BL/6J
transcript	OTTMUST00000057162	VEGA | MGI Sequence Detail	5512	Not Applicable
polypeptide	OTTMUSP00000027552	VEGA | MGI Sequence Detail	1450	Not Applicable

All sequences(49) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(260 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000007333	Fanconi anemia group D2 protein

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:188123 Garaycoechea JI, et al., Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature. 2012 Sep 27;489(7417):571-5
All references(54)

Other accession IDs

MGI:1925497, MGI:2141547, MGI:2141730