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Phenotypes Associated with This Genotype
Genotype
MGI:2673460
Allelic
Composition
Fancd2tm1Hou/Fancd2tm1Hou
Genetic
Background
129S4/SvJae-Fancd2tm1Hou
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2tm1Hou mutation (0 available); any Fancd2 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• observed in both on a 129S4/SvJae genetic background and on a background involving both 129S4/SvJae and C57BL/6J
• observed in both on a 129S4/SvJae genetic background and on a background involving both 129S4/SvJae and C57BL/6J

cellular
• apoptotic pachytene spermatocytes observed in some seminiferous tubules
• increased frequency of synaptic abnormalities beginning in mid-zygotene

endocrine/exocrine glands
• reduced number of developing follicles
• incomplete penetrance of abnormal tubules either lacking germ cells or containing apoptotic spermatocytes

reproductive system
• apoptotic pachytene spermatocytes observed in some seminiferous tubules
• increased frequency of synaptic abnormalities beginning in mid-zygotene
• reduced number of developing follicles
• incomplete penetrance of abnormal tubules either lacking germ cells or containing apoptotic spermatocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fanconi anemia complementation group D2 DOID:0111083 OMIM:227646
J:84892


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory