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Fancd2tm1Hou
Targeted Allele Detail
Summary
Symbol: Fancd2tm1Hou
Name: Fanconi anemia, complementation group D2; targeted mutation 1, Scott Houghtaling
MGI ID: MGI:2673422
Synonyms: Fancd2-
Gene: Fancd2  Location: Chr6:113508643-113573978 bp, + strand  Genetic Position: Chr6, 52.78 cM, cytoband E3
Alliance: Fancd2tm1Hou page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84892
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details220 bp encompassing exons 26 and 27 were replaced with a floxed neo-ura cassette. While RT-PCR analysis of homozygous mutant mice showed transcript lacking the targeted exons, neither normal or mutant protein arising from the detected transcript was detected by Western blot analysis. (J:84892)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Fancd2tm1Hou
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancd2 Mutation:  81 strains or lines available
References
Original:  J:84892 Houghtaling S, et al., Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev. 2003 Aug 15;17(16):2021-35
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory