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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fancd2
Fanconi anemia, complementation group D2
MGI:2448480
48 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fancd2em1(IMPC)Hmgu/Fancd2+
C57BL/6NCrl-Fancd2em1(IMPC)Hmgu/Ieg 		abnormal retina blood vessel morphology J:211773
decreased locomotor activity J:211773
increased circulating iron level J:211773
persistence of hyaloid vascular system J:211773
small kidney J:211773
Fancd2em1(IMPC)Hmgu/Fancd2em1(IMPC)Hmgu
C57BL/6NCrl-Fancd2em1(IMPC)Hmgu/Ieg 		preweaning lethality, complete penetrance J:211773
Fancd2em1Tzh/Fancd2em1Tzh
C57BL/6-Fancd2em1Tzh 		abnormal bone marrow cell morphology/development J:284566
abnormal erythropoiesis J:284566
abnormal hematopoietic stem cell physiology J:284566
abnormal lens development J:284566
abnormal ovarian follicle morphology J:284566
abnormal retina development J:284566
abnormal testis morphology J:284566
anemia J:284566
aphakia J:284566
azoospermia J:284566
decreased body size J:284566
decreased erythroblast number J:284566
decreased erythrocyte cell number J:284566
decreased hematopoietic stem cell number J:284566
decreased hemoglobin content J:284566
enlarged spleen J:284566
increased cellular sensitivity to ionizing radiation J:284566
increased erythroblast number J:284566
microphthalmia J:284566
postnatal growth retardation J:284566
postnatal lethality, incomplete penetrance J:284566
prenatal lethality, incomplete penetrance J:284566
small ovary J:284566
small testis J:284566
weakness J:284566
Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
involves: 129S5/SvEvBrd 		abnormal bone marrow cell morphology/development J:285384
decreased hematopoietic stem cell number J:285384
increased cellular sensitivity to DNA damaging agents J:285384
thrombocytopenia J:285384
Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal male meiosis J:146616
abnormal seminiferous tubule morphology J:146616
abnormal spermatocyte morphology J:146616
decreased body weight J:146616
decreased mature ovarian follicle number J:146616
fetal growth retardation J:146616
increased adenoma incidence J:146616
increased carcinoma incidence J:146616
microphthalmia J:146616
oligozoospermia J:146616
perinatal lethality, incomplete penetrance J:146616
postnatal growth retardation J:146616
small testis J:146616
Fancd2tm1Hou/Fancd2tm1Hou
129S4/SvJae-Fancd2tm1Hou 		abnormal male meiosis J:84892
abnormal ovarian follicle number J:84892
abnormal seminiferous tubule morphology J:84892
abnormal spermatocyte morphology J:84892
increased adenoma incidence J:84892
increased carcinoma incidence J:84892
oligozoospermia J:84892
small testis J:84892
Fancd2tm1Hou/Fancd2tm1Hou
B6.129S4-Fancd2tm1Hou 		decreased body weight J:84892
fetal growth retardation J:84892
microphthalmia J:84892
perinatal lethality, incomplete penetrance J:84892
postnatal growth retardation J:84892
Fancd2tm1Hou/Fancd2tm1Hou
involves: 129S4/SvJae 		decreased hematopoietic stem cell number J:188123
increased physiological sensitivity to xenobiotic J:188123
increased sensitivity to induced cell death J:188123, J:193232
infertility J:193232
normal mortality/aging J:134461
Fancd2tm1Hou/Fancd2tm1Hou
involves: 129S4/SvJae * C57BL/6J 		increased adenoma incidence J:84892
increased carcinoma incidence J:84892
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory