Sufu
Gene Detail

Symbol Name ID

Sufu suppressor of fused homolog (Drosophila) MGI:1345643

Synonyms

2810026F04Rik, b2b273Clo, Su(Fu)

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:46396896-46488804 bp, + strand From VEGA annotation of GRCm38   91909 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: suppressor of fused protein
Gene Tree: Sufu

Human homologs

Human Homolog		SUFU, suppressor of fused homolog (Drosophila)
NCBI Gene ID		51684
neXtProt AC		NX_Q9UMX1
Human Synonyms		PRO1280, SUFUH, SUFUXL
Human Chr (Location)		10q24.32; chr10:104263719-104393214 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SUFU

Alleles and phenotypes

All alleles(33) : Targeted(7) Gene trapped(25) Chemically induced(1)
 

Targeted disruption results in mid-gestation lethality, embryonic growth retardation, incomplete embryo turning, open neural tube, abnormal somite development, left-right asymmetry defects resulting in cardiac looping, and hemorrhage in the diencephalon.

 
Human Diseases Modeled Using Mouse Sufu (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(15)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cytoplasmic sequestering of transcription factor, determination of left/right symmetry, ...
Component	cilium, cytoplasm, ...
Function	beta-catenin binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (112)    Tissues (83)    Images (8)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	72
Northern blot	18
Western blot	22

cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030508 (Evidence)
Ensembl Gene Model	ENSMUSG00000025231 (Evidence)
Entrez Gene	24069 (Evidence)
DFCI	TC1580308, TC1594209, TC1598032, TC1648899
DoTS	DT.40157788, DT.527806
NIA Mouse Gene Index	U019526
Consensus CDS Project	CCDS29879.1, CCDS38008.1
International Mouse Knockout Project Status	Sufu

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030508	VEGA Gene Model | MGI Sequence Detail	91909	C57BL/6J
transcript	OTTMUST00000075542	VEGA | MGI Sequence Detail	1747	Not Applicable
polypeptide	OTTMUSP00000039623	VEGA | MGI Sequence Detail	485	Not Applicable

All sequences(59) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(444 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024314	Suppressor of fused C-terminal
InterPro	IPR020941	Suppressor of fused domain
InterPro	IPR007768	Suppressor of fused-like
InterPro	IPR016591	Suppressor of fused protein
Protein Ontology	PR:000003324	suppressor of fused homolog

References

(Earliest) J:56940 Pearse RV 2nd, et al., Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. Dev Biol. 1999 Aug 15;212(2):323-36
(Latest) J:192138 Hsu SH, et al., Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. J Biol Chem. 2012 Oct 19;287(43):36222-8
All references(70)

Other accession IDs

MGI:1919902, MGI:5313707