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Sufu
Gene Detail
 Symbol
Name
ID
Sufu
suppressor of fused homolog (Drosophila)
MGI:1345643
Synonyms 2810026F04Rik, b2b273Clo, Su(Fu)
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:46396896-46488804 bp, + strand
From VEGA annotation of GRCm38

  91909 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9262  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: suppressor of fused protein
Gene Tree: Sufu

Human
homologs
Human Homolog SUFU, suppressor of fused homolog (Drosophila)
NCBI Gene ID 51684
neXtProt AC  NX_Q9UMX1
Human Synonyms  PRO1280, SUFUH, SUFUXL
Human Chr (Location)  10q24.32; chr10:102503962-102633457 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human SUFU
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Chemically induced (ENU)(1) Gene trapped(25) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption results in mid-gestation lethality, embryonic growth retardation, incomplete embryo turning, open neural tube, abnormal somite development, left-right asymmetry defects resulting in cardiac looping, and hemorrhage in the diencephalon.
 
Human Diseases Modeled Using Mouse Sufu (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(15)
Interactions
Sufu interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cytoplasmic sequestering of transcription factor, determination of left/right symmetry, ...
Component cell, cilium, ...
Function beta-catenin binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (137)    Tissues (90)    Images (21)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 82
Northern blot 20
Western blot 25
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030508 (Evidence)
Ensembl Gene ModelENSMUSG00000025231 (Evidence)
Entrez Gene24069 (Evidence)
DFCITC1580308, TC1594209, TC1598032, TC1634433, TC1648899
DoTSDT.40157788, DT.527806
NIA Mouse Gene IndexU019526
Consensus CDS ProjectCCDS29879.1, CCDS38008.1
International Mouse Knockout Project StatusSufu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030508 VEGA Gene Model | MGI Sequence Detail 91909 C57BL/6J ±  kb
transcript OTTMUST00000075542 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000039623 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(565 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024314 Suppressor of fused C-terminal
InterPro IPR020941 Suppressor of fused domain
InterPro IPR007768 Suppressor of fused-like
InterPro IPR016591 Suppressor of fused protein
Protein Ontology PR:000003324 suppressor of fused homolog
References (Earliest) J:56940 Pearse RV 2nd, et al., Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. Dev Biol. 1999 Aug 15;212(2):323-36
(Latest) J:203679 Aavikko M, et al., Loss of SUFU function in familial multiple meningioma. Am J Hum Genet. 2012 Sep 7;91(3):520-6
All references(74)
Disease annotation references (1)
Other
accession IDs
MGI:1919902, MGI:5313707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory