Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables beta-catenin binding activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of with a negative effect on smoothened signaling pathway. Acts upstream of or within several processes, including circulatory system development; negative regulation of nitrogen compound metabolic process; and smoothened signaling pathway involved in ventral spinal cord patterning. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling).