GO Annotations Graph

• Symbol: Sufu
• Name: SUFU negative regulator of hedgehog signaling
• ID: MGI:1345643

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	IDA	J:119466
Molecular Function	GO:0005515	protein binding	IPI	J:172885
Molecular Function	GO:0005515	protein binding	IPI	J:152551
Molecular Function	GO:0005515	protein binding	IPI	J:158961
Molecular Function	GO:0005515	protein binding	IPI	J:172885
Molecular Function	GO:0005515	protein binding	IPI	J:117258
Molecular Function	GO:0005515	protein binding	IPI	J:176685
Molecular Function	GO:0005515	protein binding	IPI	J:64039
Molecular Function	GO:0005515	protein binding	IPI	J:64039
Molecular Function	GO:0005515	protein binding	IPI	J:147574
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Molecular Function	GO:0008134	transcription factor binding	ISO	J:155216
Cellular Component	GO:0005929	cilium	IDA	J:168317
Cellular Component	GO:0005929	cilium	IDA	J:168317
Cellular Component	GO:0005929	cilium	IDA	J:151923
Cellular Component	GO:0005929	cilium	IDA	J:115756
Cellular Component	GO:0005929	cilium	IDA	J:151923
Cellular Component	GO:0005737	cytoplasm	IDA	J:158961
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155216
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5610710
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610711
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610714
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610715
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610740
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-5610751
Cellular Component	GO:1990788	GLI-SUFU complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:115756
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	IBA	J:265628
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	IGI	J:103171
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	IGI	J:103171
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:101731
Biological Process	GO:0001947	heart looping	IMP	J:101731
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:1990787	negative regulation of hh target transcription factor activity	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:234100
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:105832
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:138139
Biological Process	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IMP	J:151923
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:105832
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155216
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IGI	J:151923
Biological Process	GO:0001843	neural tube closure	IMP	J:101731
Biological Process	GO:0043588	skin development	IMP	J:105832
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:260445
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:105832
Biological Process	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IMP	J:151923
Biological Process	GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	IMP	J:151923
Biological Process	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	IMP	J:151923
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	IMP	J:105832
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159