Sequence Detail

ID/Version

Q9Z0P7 Q9JLU1 Q99JG0 Q8C8B4 Q9D521 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Suppressor of fused homolog {ECO:0000303|PubMed:10531011};

Provider

SWISS-PROT

Sequence

Polypeptide 484 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sufu	SUFU negative regulator of hedgehog signaling	60	118	3	47

Sequence references in MGI

J:58014 Ding Q, et al., Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol. 1999 Oct 7;9(19):1119-22
J:64039 Delattre M, et al., The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals. Dev Genes Evol. 1999 May;209(5):294-300
J:71567 Grimm T, et al., Genomic organization and embryonic expression of Suppressor of Fused, a candidate gene for the split-hand/split-foot malformation type 3. FEBS Lett. 2001 Sep 7;505(1):13-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101731 Cooper AF, et al., Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development. 2005 Oct;132(19):4407-17
J:105832 Svard J, et al., Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell. 2006 Feb;10(2):187-97
J:119466 Meng X, et al., Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem. 2001 Oct 26;276(43):40113-9
J:152551 Endoh-Yamagami S, et al., The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6
J:158961 Humke EW, et al., The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 2010 Apr 1;24(7):670-82
J:189074 Li ZJ, et al., Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development. 2012 Nov;139(22):4152-61
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89