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Gene Detail
transformation related protein 63
Synonyms deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1
Feature Type protein coding gene
Genetic Map
Chromosome 16
17.37 cM
Detailed Genetic Map ± 1 cM

Mapping data(5)
Sequence Map
Chr16:25683763-25892102 bp, + strand
From VEGA annotation of GRCm38

  208340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:31189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trp63

Human Homolog TP63, tumor protein p63
NCBI Gene ID 8626
neXtProt AC  NX_Q9H3D4
Human Synonyms  AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
Human Chr (Location)  3q28; chr3:189631160-189897279 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human TP63
alleles, and
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamus epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have missing or truncated limbs, small genitalia, and die perinatally.
Human Diseases Modeled Using Mouse Trp63 (4)    Alleles Annotated to Human Diseases(4)   
Trp63 interacts with 396 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (125 annotations)
Process anatomical structure formation involved in morphogenesis, apoptotic process, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, damaged DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (163 records)
Data Summary: Results (398)    Tissues (148)    Images (135)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 144
RNA in situ 150
RT-PCR 104
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(56) Genomic(3) cDNA(39) Primer pair(14)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000021015 (Evidence)
Ensembl Gene ModelENSMUSG00000022510 (Evidence)
Entrez Gene22061 (Evidence)
DFCITC1587776, TC1596989, TC1598878, TC1624076, TC1653227, TC1716618
DoTSDT.101231366, DT.40153044, DT.483864, DT.87056400, DT.91300380, DT.91554738, DT.91573320, DT.94138923, DT.97343678
NIA Mouse Gene IndexU016972
Consensus CDS ProjectCCDS28085.1, CCDS49808.1, CCDS49809.1, CCDS49810.1, CCDS49811.1, CCDS49812.1
International Mouse Knockout Project StatusTrp63
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021015 VEGA Gene Model | MGI Sequence Detail 208340 C57BL/6J ±  kb
transcript OTTMUST00000049678 VEGA | MGI Sequence Detail 5366 Not Applicable 
polypeptide OTTMUSP00000023061 VEGA | MGI Sequence Detail 680 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(24) UniProt(5)
Polymorphisms All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs within 2kb(1210 from dbSNP Build 137)
InterPro IPR011615 p53, DNA-binding domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
InterPro IPR010991 p53, tetramerisation domain
InterPro IPR002117 p53 tumour suppressor family
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000016567 tumor protein 63
References (Earliest) J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
(Latest) J:210664 Restelli M, et al., DLX5, FGF8 and the Pin1 isomerase control DeltaNp63alpha protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations. Hum Mol Genet. 2014 Jul 15;23(14):3830-42
All references(274)
Disease annotation references (5)
accession IDs
MGI:1196329, MGI:1332227, MGI:2146440

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory