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Trp63 Gene Detail
Summary
  • Symbol
    Trp63
  • Name
    transformation related protein 63
  • Synonyms
    deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330810
    NCBI Gene: 22061
  • Gene Overview
    MyGene.info: TP63
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:25683763-25892102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      208340 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 17.37 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TP63, tumor protein p63
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TP63, tumor protein p63
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
  • Links
    NCBI Gene ID: 8626
    neXtProt AC: NX_Q9H3D4
    UniProt: Q9H3D4

  • Chr Location
    3q28; chr3:189597115-189897279 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31189
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TP63
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with Trp63 mouse models; 5 with human TP63 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 3 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    149 phenotypes from 17 alleles in 16 genetic backgrounds
    26 phenotypes from multigenic genotypes
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamous epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have craniofacial anomalies, missing or truncated limbs, and small genitalia, and they die perinatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021015 VEGA Gene Model | MGI Sequence Detail 208340 C57BL/6J ±  kb
    transcript OTTMUST00000049678 VEGA | MGI Sequence Detail 5366 Not Applicable  
    polypeptide OTTMUSP00000023061 VEGA | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1204 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 3
      cDNA 40
      Primer pair 15
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1196329, MGI:1332227, MGI:2146440
    References
    more
    • Summaries
      All 429
      Developmental Gene Expression 261
      Diseases 5
      Gene Ontology 51
      Phenotypes 115
    • Earliest
      J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
    • Latest
      J:264609 Li J, et al., Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory