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Trp63 Gene Detail
Summary
  • Symbol
    Trp63
  • Name
    transformation related protein 63
  • Synonyms
    deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330810
    NCBI Gene: 22061
  • Gene Overview
    MyGene.info: TP63
Location & Maps
more
  • Sequence Map
    Chr16:25683763-25892102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      208340 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TP63, tumor protein p63
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TP63, tumor protein p63
    Orthology source: HomoloGene
  • Synonyms
    AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
  • Links
    NCBI Gene ID: 8626
    neXtProt AC: NX_Q9H3D4

  • Chr Location
    3q28; chr3:189566861-189897279 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31189
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TP63
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with Trp63 mouse models; 6 with human TP63 associations

Human Disease Mouse Models
       Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate   OMIM: 106260 View 1 model
Ectrodactyly, Ectodermal Dysplasia, and Cleft Lip/Palate Syndrome 3; EEC3   OMIM: 604292 View 3 models
       Exstrophy of Bladder   OMIM: 600057 View 1 model
Gastroesophageal Reflux; GER   OMIM: 109350 View 1 model
       ADULT Syndrome   OMIM: 103285
Limb-Mammary Syndrome; LMS   OMIM: 603543
Rapp-Hodgkin Syndrome; RHS   OMIM: 129400
Split-Hand/Foot Malformation 4; SHFM4   OMIM: 605289
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    149 phenotypes from 17 alleles in 16 genetic backgrounds
    26 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Targeted
    20
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamous epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have craniofacial anomalies, missing or truncated limbs, and small genitalia, and they die perinatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021015 VEGA Gene Model | MGI Sequence Detail 208340 C57BL/6J ±  kb
transcript OTTMUST00000049678 VEGA | MGI Sequence Detail 5366 Not Applicable  
polypeptide OTTMUSP00000023061 VEGA | MGI Sequence Detail 680 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1204 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016567 tumor protein 63
  • InterPro Domains
    IPR011615 p53, DNA-binding domain
    IPR008967 p53-like transcription factor, DNA-binding
    IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
    IPR010991 p53, tetramerisation domain
    IPR002117 p53 tumour suppressor family
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR032645 Tumour protein p63
Molecular
Reagents
less
  • All nucleic 57
    Genomic 3
    cDNA 39
    Primer pair 14
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1196329, MGI:1332227, MGI:2146440
References
more
  • Summaries
    All 328
    Developmental Gene Expression 208
    Diseases 5
    Gene Ontology 51
    Phenotypes 93
  • Earliest
    J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
  • Latest
    J:226997 Bebee TW, et al., The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory