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Trp63
Gene Detail
Symbol

Name
ID
Trp63
transformation related protein 63
MGI:1330810
Synonyms
deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
17.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:25683763-25892102 bp, + strand
From VEGA annotation of GRCm38

  208340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Trp63

Human
homologs
Human Homolog TP63, tumor protein p63
NCBI Gene ID 8626
neXtProt AC  NX_Q9H3D4
Human Synonyms  AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
Human Chr (Location)  3q28; chr3:189631160-189897279 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human TP63
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamus epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have missing or truncated limbs, small genitalia, and die perinatally.
 
Human Diseases Modeled Using Mouse Trp63 (4)    Alleles Annotated to Human Diseases(4)   
Interactions
Trp63 interacts with 396 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (126 annotations)
Process anatomical structure formation involved in morphogenesis, apoptotic process, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, damaged DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (168 records)
Data Summary: Results (398)    Tissues (148)    Images (135)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 144
RNA in situ 150
RT-PCR 104
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(3) cDNA(39) Primer pair(14)
Microarray probesets(6)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021015 VEGA Gene Model | MGI Sequence Detail 208340 C57BL/6J ±  kb
transcript OTTMUST00000049678 VEGA | MGI Sequence Detail 5366 Not Applicable 
polypeptide OTTMUSP00000023061 VEGA | MGI Sequence Detail 680 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(24) UniProt(9)
Polymorphisms
All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs within 2kb(1210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011615 p53, DNA-binding domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR012346 p53/RUNT-type transcription factor, DNA-binding domain
InterPro IPR010991 p53, tetramerisation domain
InterPro IPR002117 p53 tumour suppressor family
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000016567 tumor protein 63
References
(Earliest) J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
(Latest) J:212617 Tan EH, et al., Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene. 2014 Jun 19;33(25):3325-33
All references(279)
Disease annotation references (5)
Other
accession IDs
MGI:1196329, MGI:1332227, MGI:2146440

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory