Trp63
Gene Detail

Symbol Name ID

Trp63 transformation related protein 63 MGI:1330810

Synonyms

deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

17.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:25683763-25892102 bp, + strand From VEGA annotation of GRCm38   208340 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trp63 ± 2 cM)

Gene Tree: Trp63

Human ortholog

TP63 tumor protein p63 NCBI Gene ID 8626
Human Synonyms: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
Human Chr3:189349216-189615068 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human TP63 (6)

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamus epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have missing or truncated limbs, small genitalia, and die perinatally.

 
Human Diseases Modeled Using Mouse Trp63 (4)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (108 annotations)

Process	anatomical structure formation involved in morphogenesis, apoptotic process, ...
Component	chromatin, cytoplasm, ...
Function	chromatin binding, damaged DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (137 records)
Data Summary: Results (272)    Tissues (105)    Images (67)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	58
RNA in situ	150
RT-PCR	64

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(3) cDNA(39) Primer pair(9)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021015 (Evidence)
Ensembl Gene Model	ENSMUSG00000022510 (Evidence)
Entrez Gene	22061 (Evidence)
UniGene	20894
DFCI	TC1587776, TC1596989, TC1598878, TC1624076, TC1653227, TC1716618
DoTS	DT.101231366, DT.40153044, DT.483864, DT.87056400, DT.91300380, DT.91554738, DT.91573320, DT.94138923, DT.97343678
NIA Mouse Gene Index	U016972
Consensus CDS Project	CCDS28085.1, CCDS49808.1, CCDS49809.1, CCDS49810.1, CCDS49811.1, CCDS49812.1
International Mouse Knockout Project Status	Trp63

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021015	VEGA Gene Model | MGI Sequence Detail	208340	C57BL/6J
transcript	OTTMUST00000049678	VEGA | MGI Sequence Detail	5366	Not Applicable
polypeptide	OTTMUSP00000023061	VEGA | MGI Sequence Detail	680	Not Applicable

All sequences(86) RefSeq(16) UniProt(5)

Polymorphisms

All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs(336 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011615	p53, DNA-binding domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain
InterPro	IPR010991	p53, tetramerisation domain
InterPro	IPR002117	p53 tumour suppressor family
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000016567	tumor protein 63

References

(Earliest) J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
(Latest) J:193630 Fujimoto A, et al., GJB6, of which mutations underlie Clouston syndrome, is a potential direct target gene of p63. J Dermatol Sci. 2013 Feb;69(2):159-66
All references(231)

Other accession IDs

MGI:1196329, MGI:1332227, MGI:2146440