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Trp63 Gene Detail
Summary
  • Symbol
    Trp63
  • Name
    transformation related protein 63
  • Synonyms
    deltaNp63, KET protein, p51/p63, p63, p73L, TAp63, Trp53rp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330810
    NCBI Gene: 22061
  • Gene Overview
    MyGene.info: TP63
Location & Maps
more
  • Sequence Map
    Chr16:25683763-25892102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      208340 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 17.37 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TP63, tumor protein p63
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TP63, tumor protein p63
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L
  • Links
    NCBI Gene ID: 8626
    neXtProt AC: NX_Q9H3D4
    UniProt: Q9H3D4

  • Chr Location
    3q28; chr3:189597115-189897279 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31189
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TP63
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with Trp63 mouse models; 5 with human TP63 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 3 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    149 phenotypes from 17 alleles in 16 genetic backgrounds
    26 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations lack hair follicles, teeth, eyelids, and all squamous epithelia and derivatives including mammary, lacrymal, salivary, and prostate glands. Mutants have craniofacial anomalies, missing or truncated limbs, and small genitalia, and they die perinatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021015 VEGA Gene Model | MGI Sequence Detail 208340 C57BL/6J ±  kb
transcript OTTMUST00000049678 VEGA | MGI Sequence Detail 5366 Not Applicable  
polypeptide OTTMUSP00000023061 VEGA | MGI Sequence Detail 680 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1204 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 59
    Genomic 3
    cDNA 39
    Primer pair 15
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1196329, MGI:1332227, MGI:2146440
References
more
  • Summaries
    All 360
    Developmental Gene Expression 227
    Diseases 5
    Gene Ontology 52
    Phenotypes 103
  • Earliest
    J:43056 Schmale H, et al., A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997 Sep;15(11):1363-7
  • Latest
    J:243551 Kataoka K, et al., Bhlha9 regulates apical ectodermal ridge formation during limb development. J Bone Miner Metab. 2017 Mar 21;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory