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Phenotypes Associated with This Genotype
Genotype
MGI:6477390
Allelic
Composition
Trp63tm3Aam/Trp63+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3Aam mutation (0 available); any Trp63 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected numbers of mice are seen at weaning with 18% lethality; lethality is apparent at birth

growth/size/body
• defective tooth morphogenesis with abnormal root structures and hyperdontia
• abnormal root structures
• palatal shelves have not fused at E18.5
• adhesion and fusion of the secondary palate is stalled in a subset of E15 fetuses, appearing similar to palates of E13.5 wild-type mice
• severe cleft palate, with 15.4% of neonates exhibiting clefting

behavior/neurological
• newborns with cleft palate show absence of a milk pouch in the stomach

craniofacial
• defective tooth morphogenesis with abnormal root structures and hyperdontia
• abnormal root structures
• palatal shelves have not fused at E18.5
• adhesion and fusion of the secondary palate is stalled in a subset of E15 fetuses, appearing similar to palates of E13.5 wild-type mice
• severe cleft palate, with 15.4% of neonates exhibiting clefting

digestive/alimentary system
• palatal shelves have not fused at E18.5
• adhesion and fusion of the secondary palate is stalled in a subset of E15 fetuses, appearing similar to palates of E13.5 wild-type mice
• severe cleft palate, with 15.4% of neonates exhibiting clefting

integument
• mice exhibit alopecia with age
• mice exhibit ruffled coat with age
• dystrophic nails
• primary keratinocytes exhibit reduced proliferation and a corresponding increase in cellular senescence
• however, no major skin abnormalities are seen at E16.5 or P0
• primary keratinocytes exhibit reduced proliferation

limbs/digits/tail
• anomalies of the distal limbs

skeleton
• defective tooth morphogenesis with abnormal root structures and hyperdontia
• abnormal root structures

vision/eye
• mice exhibit eye squinting with age

cellular
• primary keratinocytes exhibit reduced proliferation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory