Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables chromatin binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including establishment of skin barrier; negative regulation of intracellular estrogen receptor signaling pathway; and regulation of epidermal cell division. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of keratinocyte differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; non-neural ectoderm; and sensory organ. Used to study ankyloblepharon-ectodermal defects-cleft lip/palate syndrome; bladder exstrophy; ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3; and gastroesophageal reflux disease. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63).

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Gene Ontology Evidence Code Abbreviations:

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