Symbol Name ID |
Trp63
transformation related protein 63 MGI:1330810 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Alopecia of scalp |
Sparse scalp hair |
Sparse eyebrow |
Absent eyelashes |
Sparse eyelashes |
Palmoplantar keratoderma |
Wide intermamillary distance |
Absent nipple |
Hypoplastic nipples |
Supernumerary nipple |
Breast hypoplasia |
Eczematoid dermatitis |
Patchy alopecia |
Progressive alopecia |
Facial hirsutism |
Sparse hair |
Sparse axillary hair |
Sparse body hair |
Sparse pubic hair |
Pili canaliculi |
Pili torti |
Slow-growing hair |
Fair hair |
Coarse hair |
Fine hair |
Uncombable hair |
Decreased number of sweat glands |
Dystrophic fingernails |
Dystrophic toenail |
Anonychia |
Small nail |
Hyperconvex nail |
Hyperconvex fingernails |
Nail pits |
Nail dystrophy |
Onychogryposis |
Anhidrosis |
Hypohidrosis |
Freckling |
Hyperpigmentation of the skin |
Generalized hyperpigmentation |
Generalized hypopigmentation |
Dry skin |
Cutaneous photosensitivity |
Ectodermal dysplasia |
Anhidrotic ectodermal dysplasia |
Dermal atrophy |
Thin skin |
Adermatoglyphia |
Hyperkeratosis |
Disease(s) Associated with TP63 | ||||||||||||||||||||||||||||||||||||||||||||||||||
ADULT syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
Rapp-Hodgkin syndrome |
Mouse Phenotypes | integument phenotype |
abnormal keratinocyte differentiation |
decreased keratinocyte proliferation |
absent mammary gland |
absent sebaceous gland |
impaired skin barrier function |
alopecia |
ruffled hair |
abnormal hair shaft morphology |
nail dystrophy |
abnormal hair follicle development |
absent hair follicles |
decreased hair follicle number |
absent vibrissae |
abnormal skin morphology |
thick dermal layer |
abnormal epidermal layer morphology |
abnormal epidermis stratum basale morphology |
thick epidermis stratum basale |
absent epidermis stratum corneum |
absent epidermis stratum granulosum |
abnormal epidermis stratum spinosum morphology |
absent epidermis stratum spinosum |
acanthosis |
thick epidermis stratum spinosum |
abnormal keratinocyte morphology |
absent epidermis |
thick epidermis |
dermal-epidermal separation |
blistering |
shiny skin |
skin lesions |
spontaneous skin ulceration |
translucent skin |
wrinkled skin |
abnormal skin condition |
abnormal skin development |
abnormal skin physiology |
abnormal keratinocyte physiology |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||
Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig | ||||||||||||||||||||||||||||||||||||||||
Trp63tm1.1Elrf/Trp63tm1.1Elrf | ||||||||||||||||||||||||||||||||||||||||
Trp63tm1Brd/Trp63tm1Brd | ||||||||||||||||||||||||||||||||||||||||
Trp63tm1Fmc/Trp63tm1Fmc | ||||||||||||||||||||||||||||||||||||||||
Trp63tm1Sin/Trp63tm1Sin | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2.2Elrf/Trp63tm2.2Elrf | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2Brd/Trp63tm2Brd | ||||||||||||||||||||||||||||||||||||||||
Trp63tm3.1Aam/Trp63tm3.1Aam | ||||||||||||||||||||||||||||||||||||||||
Trp63tm3.2Aam/Trp63tm3.2Aam | ||||||||||||||||||||||||||||||||||||||||
Trp63tm3.2Brd/Trp63tm3.2Brd | ||||||||||||||||||||||||||||||||||||||||
Trp63tm3Aam/Trp63tm3Aam | ||||||||||||||||||||||||||||||||||||||||
Trp63tm1Cmis/Trp63+ | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2.1Aam/Trp63tm3.1Aam | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2.1Aam/Trp63tm3.2Aam | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2.1Aam/Trp63tm3Aam | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2.2Elrf/Trp63+ | ||||||||||||||||||||||||||||||||||||||||
Trp63tm2Brd/Trp63+ | ||||||||||||||||||||||||||||||||||||||||
Trp63tm3.1Aam/Trp63+ | ||||||||||||||||||||||||||||||||||||||||
Trp63tm3Aam/Trp63+ | ||||||||||||||||||||||||||||||||||||||||
Trp63tm1Elrf/Trp63tm1Elrf Tg(KRT14-cre)8Brn/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||
Tg(KRT5-cre/PGR)1Der/0 Trp63tm2Brd/Trp63tm3.1Brd (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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