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Snca Gene Detail
Summary
  • Symbol
    Snca
  • Name
    synuclein, alpha
  • Synonyms
    alphaSYN, alpha-synuclein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277151
    NCBI Gene: 20617
  • Gene Overview
    MyGene.info: SNCA
Location & Maps
more
  • Sequence Map
    Chr6:60731575-60829855 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      98281 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 29.15 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SNCA, synuclein alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SNCA, synuclein alpha
    Orthology source: HomoloGene
  • Synonyms
    NACP, PARK1, PARK4, PD1
  • Links
    NCBI Gene ID: 6622
    neXtProt AC: NX_P37840

  • Chr Location
    4q21; chr4:89724099-89838314 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Snca mouse models; 3 with human SNCA associations

Human Disease Mouse Models
       Parkinson Disease 1, Autosomal Dominant; PARK1   OMIM: 168601 View 23 models
Parkinson Disease 4, Autosomal Dominant; PARK4   OMIM: 605543 View 2 models
       Dementia, Lewy Body; DLB   OMIM: 127750 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    32 with disease annotations
  • References
    47 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 9 alleles in 8 genetic backgrounds
    185 phenotypes from multigenic genotypes
    256 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    67
  • Targeted
    11
  • Transgenic
    56
Mice homozygous for disruptions in this gene display resistance to the effects of MPTP on dopamine levels. Mice expressing a knock-in allele exhibit impaired coordination, long stride length, abnromal response to reserpine and reduced brain dopamine levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057624 VEGA Gene Model | MGI Sequence Detail 98281 C57BL/6J ±  kb
transcript OTTMUST00000141608 VEGA | MGI Sequence Detail 1188 Not Applicable  
polypeptide OTTMUSP00000073978 VEGA | MGI Sequence Detail 140 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    568 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 44
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 182
    Developmental Gene Expression 21
    Diseases 47
    Gene Ontology 37
    Phenotypes 256
  • Earliest
    J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
  • Latest
    J:232135 Dodson PD, et al., Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2180-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory