Snca MGI Mouse Gene Detail - MGI:1277151

Snca Gene Detail

Symbol

Snca
Name

synuclein, alpha
Synonyms

alphaSYN, alpha-synuclein

Feature Type

protein coding gene
IDs

MGI:1277151
NCBI Gene: 20617
Gene Overview

MyGene.info: SNCA

Sequence Map

Chr6:60731575-60829855 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

98281 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 29.15 cM
Mapping Data

4 experiments

Human Ortholog

SNCA, synuclein alpha

Vertebrate Orthologs

8

Human Ortholog

SNCA, synuclein alpha
Orthology source: HomoloGene, HGNC
Synonyms

NACP, PARK1, PARK4, PD1
Links

HGNC:11138

NCBI Gene ID: 6622

neXtProt AC: NX_P37840
Chr Location

4q21; chr4:89724099-89838314 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 293
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: SNCA
Protein SuperFamily

synuclein
Gene Tree

Snca

Diseases

2 with Snca mouse models; 3 with human SNCA associations

Human Disease

Mouse Models

Parkinson Disease 1, Autosomal Dominant; PARK1 OMIM: 168601

View 23 models

Parkinson Disease 4, Autosomal Dominant; PARK4 OMIM: 605543

View 2 models

Dementia, Lewy Body; DLB OMIM: 127750

View 3 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

32 with disease annotations

References

48 with disease annotations

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Phenotype Summary

37 phenotypes from 9 alleles in 8 genetic backgrounds
185 phenotypes from multigenic genotypes
258 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Targeted

11
Transgenic

56

Mice homozygous for disruptions in this gene display resistance to the effects of MPTP on dopamine levels. Mice expressing a knock-in allele exhibit impaired coordination, long stride length, abnromal response to reserpine and reduced brain dopamine levels.

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All GO Annotations

143
GO References

37

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

76
Tissues

54
cDNA Data

43
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase snca

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Snca interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS20201.1
UniGene

17484

			Length	Strain/Species	Flank
genomic	OTTMUSG00000057624	VEGA Gene Model \| MGI Sequence Detail	98281	C57BL/6J	± kb
transcript	OTTMUST00000141608	VEGA \| MGI Sequence Detail	1188	Not Applicable
polypeptide	OTTMUSP00000073978	VEGA \| MGI Sequence Detail	140	Not Applicable

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SNPs within 2kb

568 from dbSNP Build 142

PCR

3

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UniProt

1 Sequence
Protein Ontology

PR:000015322 alpha-synuclein
InterPro Domains

IPR002460 Alpha-synuclein

IPR001058 Synuclein

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All nucleic 47

cDNA 44

Primer pair 3

Microarray probesets 4

Summaries

All 182

Developmental Gene Expression 21

Diseases 48

Gene Ontology 37

Phenotypes 258
Earliest

J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
Latest

J:232135 Dodson PD, et al., Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2180-8

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/13/2016 MGI 6.05