Snca
Gene Detail

Symbol Name ID

Snca synuclein, alpha MGI:1277151

Synonyms

alphaSYN, alpha-synuclein

Feature Type

protein coding gene

Genetic Map

Chromosome 6

29.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:60731573-60829855 bp, - strand From NCBI annotation of GRCm38   98283 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: synuclein
Gene Tree: Snca

Human homologs

Human Homolog		SNCA, synuclein, alpha (non A4 component of amyloid precursor)
NCBI Gene ID		6622
neXtProt AC		NX_P37840
Human Synonyms		NACP, PARK1, PARK4, PD1
Human Chr (Location)		4q21; chr4:89724099-89838296 (-)  GRCh38
Disease Associations		(3) Diseases Associated with Human SNCA

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for disruptions in this gene display resistance to the effects of MPTP on dopamine levels. Mice expressing a knock-in allele exhibit impaired coordination, long stride length, abnromal response to reserpine and reduced brain dopamine levels.

 
Human Diseases Modeled Using Mouse Snca (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (135 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, adult locomotory behavior, ...
Component	actin cytoskeleton, axon, ...
Function	alpha-tubulin binding, arachidonic acid binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)

Data Summary: Results (67)    Tissues (43)    Images (11)
Theiler Stages: 19, 20, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	47
Northern blot	8

cDNA source data(43)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(44) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025889 (Evidence)
Entrez Gene	20617 (Evidence)
UniGene	17484
DFCI	TC1574723, TC1590229, TC1595472, TC1691341
DoTS	DT.91340588, DT.91392401, DT.94307842, DT.94307844, DT.94307853
NIA Mouse Gene Index	U027382
Consensus CDS Project	CCDS20201.1
International Mouse Knockout Project Status	Snca

Sequences

Length	Strain/Species
genomic	20617	NCBI Gene Model | MGI Sequence Detail	98283	C57BL/6J
transcript	NM_001042451	RefSeq | MGI Sequence Detail	1304	C57BL/6
polypeptide	O55042	UniProt | EBI | MGI Sequence Detail	140	Not Applicable

All sequences(31) RefSeq(4) UniProt(1)

Polymorphisms

PCR(3) : SNPs within 2kb(568 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002460	Alpha-synuclein
InterPro	IPR001058	Synuclein
Protein Ontology	PR:000015322	alpha-synuclein

Graphical View of Protein Domain Structure

References

(Earliest) J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
(Latest) J:208568 Steneberg P, et al., The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells. Diabetes. 2013 Jun;62(6):2004-14
All references(160)