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Snca Gene Detail
Summary
  • Symbol
    Snca
  • Name
    synuclein, alpha
  • Synonyms
    alpha-Syn, alphaSYN, alpha-synuclein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277151
    NCBI Gene: 20617
  • Gene Overview
    MyGene.info: SNCA
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:60731575-60829855 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      98281 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 29.15 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SNCA, synuclein alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SNCA, synuclein alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NACP, PARK1, PARK4, PD1
  • Links
    NCBI Gene ID: 6622
    neXtProt AC: NX_P37840
    UniProt: P37840

  • Chr Location
    4q22.1; chr4:89724099-89838324 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Snca mouse models; 3 with human SNCA associations

Human Disease Mouse Models
      
IDs
 View 23 models
IDs
 View 1 model
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    36 with disease annotations
  • References
    36 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 9 alleles in 8 genetic backgrounds
    188 phenotypes from multigenic genotypes
    331 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display resistance to the effects of MPTP on dopamine levels. Mice expressing a knock-in allele exhibit impaired coordination, long stride length, abnormal response to reserpine and reduced brain dopamine levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    162
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    83
  • Tissues
    58
  • cDNA Data
    44
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057624 VEGA Gene Model | MGI Sequence Detail 98281 C57BL/6J ±  kb
    transcript OTTMUST00000141608 VEGA | MGI Sequence Detail 1188 Not Applicable  
    polypeptide OTTMUSP00000073978 VEGA | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      568 from dbSNP Build 142
    • PCR
      3
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 45
      Primer pair 3
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 448
      Developmental Gene Expression 24
      Diseases 36
      Gene Ontology 39
      Phenotypes 331
    • Earliest
      J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
    • Latest
      J:262885 Pupyshev AB, et al., Suppression of autophagy in the brain of transgenic mice with overexpression of capital A, Cyrillic53capital TE, Cyrillic-mutant alpha-synuclein as an early event at synucleinopathy progression. Neurosci Lett. 2018 Apr 13;672:140-144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory