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Snca
Gene Detail
 Symbol
Name
ID
Snca
synuclein, alpha
MGI:1277151
Synonyms alphaSYN, alpha-synuclein
Feature Type protein coding gene
Genetic Map
Chromosome 6
29.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:60731573-60829855 bp, - strand
From NCBI annotation of GRCm38

  98283 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: synuclein
Gene Tree: Snca

Human
homologs
Human Homolog SNCA, synuclein, alpha (non A4 component of amyloid precursor)
NCBI Gene ID 6622
neXtProt AC  NX_P37840
Human Synonyms  NACP, PARK1, PARK4, PD1
Human Chr (Location)  4q21; chr4:89724099-89838296 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human SNCA
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for disruptions in this gene display resistance to the effects of MPTP on dopamine levels. Mice expressing a knock-in allele exhibit impaired coordination, long stride length, abnromal response to reserpine and reduced brain dopamine levels.
 
Human Diseases Modeled Using Mouse Snca (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Snca interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (138 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, adult locomotory behavior, ...
Component actin cytoskeleton, axon, ...
Function alpha-tubulin binding, arachidonic acid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (67)    Tissues (47)    Images (11)
Theiler Stages: 19, 20, 22, 23, 24, 25, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 47
Northern blot 8
cDNA source data(43)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(44) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025889 (Evidence)
Entrez Gene20617 (Evidence)
UniGene17484
DFCITC1574723, TC1590229, TC1595472, TC1691341
DoTSDT.91340588, DT.91392401, DT.94307842, DT.94307844, DT.94307853
NIA Mouse Gene IndexU027382
Consensus CDS ProjectCCDS20201.1
International Mouse Knockout Project StatusSnca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20617 NCBI Gene Model | MGI Sequence Detail 98283 C57BL/6J ±  kb
transcript NM_001042451 RefSeq | MGI Sequence Detail 1304 C57BL/6 
polypeptide O55042 UniProt | EBI | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(1)
Polymorphisms PCR(3) : SNPs within 2kb(568 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002460 Alpha-synuclein
InterPro IPR001058 Synuclein
Protein Ontology PR:000015322 alpha-synuclein
Graphical View of Protein Domain Structure
References (Earliest) J:48620 Hsu LJ, et al., Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. J Neurochem. 1998 Jul;71(1):338-44
(Latest) J:208568 Steneberg P, et al., The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells. Diabetes. 2013 Jun;62(6):2004-14
All references(160)
Disease annotation references (4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory