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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Snca
synuclein, alpha
MGI:1277151
54 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd
Sncatm1Wtd/Sncatm1Wtd
involves: 129 * C57BL/6 		abnormal lysosome morphology J:221680
gliosis J:221680
Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
involves: 129P2/OlaHsd * 129S6/SvEvTac 		premature death J:115193
Dnajc5tm1Sud/Dnajc5tm1Sud
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud
involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		decreased body weight J:115193
neurodegeneration J:115193
premature death J:115193
Dnajc5tm1Sud/Dnajc5tm1Sud
Tg(THY1-Snca)M1mSud/0
involves: 129S6/SvEvTac * C57BL/6 		normal behavior/neurological phenotype J:115193
normal homeostasis/metabolism phenotype J:115193
normal mortality/aging J:115193
retina photoreceptor degeneration J:115193
Slc6a3tm1(cre)Lrsn/Slc6a3+
Sncatm1Nbm/Sncatm1Nbm
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL 		neuronal intranuclear inclusions J:119515
Sncatm1Nbm/Sncatm1Nbm
Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
involves: 129S6/SvEvTac * FVB/N 		abnormal axon morphology J:124976
abnormal gait J:124976
abnormal male preputial gland morphology J:124976
abnormal motor capabilities/coordination/movement J:124976
abnormal posture J:124976
abnormal reflex J:124976
abnormal spinal cord ventral horn morphology J:124976
abnormal spinal nerve morphology J:124976
abnormal ventral spinal root morphology J:124976
axon degeneration J:124976
gliosis J:124976
kyphosis J:124976
neuronal intranuclear inclusions J:124976
premature death J:124976
short stride length J:124976
slow postnatal weight gain J:124976
weakness J:124976
weight loss J:124976
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
involves: 129S6/SvEvTac * FVB/N 		abnormal intestinal transit time J:156741
abnormal large intestinal transit time J:156741
normal behavior/neurological phenotype J:156741
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A53T)1Nbm/Tg(SNCA*A53T)1Nbm
Tg(SNCA*A53T)2Nbm/Tg(SNCA*A53T)2Nbm
involves: 129S6/SvEvTac * FVB/N 		abnormal digestive system physiology J:156741
abnormal hippocampus morphology J:156741
abnormal intestinal transit time J:156741
abnormal large intestinal transit time J:156741
alpha-synuclein inclusion body J:156741
normal cardiovascular system phenotype J:156741
decreased locomotor activity J:156741
normal growth/size/body region phenotype J:156741
impaired coordination J:156741
normal nervous system phenotype J:156741
normal taste/olfaction phenotype J:156741
Sncatm1Rosl/Sncatm1Rosl
Sncgtm1Vlb/Sncgtm1Vlb
B6.129-Sncatm1Rosl Sncgtm1Vlb 		normal behavior/neurological phenotype J:92213
decreased dopaminergic neuron number J:92213
decreased susceptibility to dopaminergic neuron neurotoxicity J:92213
normal nervous system phenotype J:92213
Sncatm1Rosl/Sncatm1Rosl
Tg(Prnp-SNCA)7Vle/Tg(Prnp-SNCA)7Vle
involves: 129X1/SvJ * C3H * C57BL/6 		abnormal response to infection J:138194
astrocytosis J:138194
loss of dopaminergic neurons J:138194
Sncatm1Rosl/Sncatm1Rosl
Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
involves: 129X1/SvJ * C3H * C57BL/6 		astrocytosis J:138194
increased susceptibility to bacterial infection J:138194
loss of dopaminergic neurons J:138194
Sncatm1Rosl/Sncatm1Rosl
Tg(SNCA)OVX37Rwm/0
B6.Cg-Tg(SNCA)OVX37Rwm Sncatm1Rosl 		abnormal dopaminergic neuron morphology J:201991
abnormal neuron physiology J:201991
abnormal synaptic dopamine release J:201991
constipation J:201991
impaired coordination J:201991
increased dopamine level J:201991
loss of dopaminergic neurons J:201991
neuron degeneration J:201991
short stride length J:201991
Sncatm1Rosl/Sncatm1Rosl
Tg(SNCA*A30P)192Rwm/0
B6.Cg-Sncatm1Rosl Tg(SNCA*A30P)#Rwm 		abnormal nervous system physiology J:201961
normal behavior/neurological phenotype J:201961
decreased dopamine level J:201961
normal digestive/alimentary phenotype J:201961
increased locomotor activity J:201961
Sncatm1Sud/Sncatm1Sud
Sncbtm1.1Sud/Sncbtm1.1Sud
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal striatum morphology J:93544
decreased dopamine level J:93544
Tg(Thy1-Snca)1S13Putt/0
Uchl1tm1Dgen/Uchl1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		alpha-synuclein inclusion body J:207278
astrocytosis J:207278
decreased grip strength J:207278
impaired coordination J:207278
premature death J:207278
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory