Uchl1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Uchl1^tm1Dgen
• Name: ubiquitin carboxy-terminal hydrolase L1; targeted mutation 1, Deltagen
• MGI ID: MGI:3604452
• Gene: Uchl1 Location: Chr5:66833464-66844577 bp, + strand Genetic Position: Chr5, 35.95 cM
• Alliance: Uchl1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 through 8 and the first 6 bases of exon 9 were replaced by a lacZ-neomycin cassette. RT-PCR analysis detected a gene transcript in most tissues analyzed except for Harderian glands, liver, lymph nodes, bone marrow and skeletal muscle. Beta-galactosidase expression from this allele was detectable in brain, spinal cord, eyes, heart, pancreas, kidney, urinary bladder, pituitary gland, adrenal glands, testis, prostate gland, ovary and cervix. Western blot analysis of brain and spinal cord homogenates failed to detect any protein product. (J:156538)

Disease models

Expression

In Mice Carrying this Mutation:	69 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uchl1 Mutation: 29 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 8 reference(s)