Phenotypes Associated with This Genotype

Genotype
MGI:5696738

• Allelic Composition: Tg(Camk2a-SNCA*)2Mgsp/0; Del(6Snca)1Slab/Del(6Snca)1Slab
• Genetic Background: B6JOlaHsd.Cg-Tg(Camk2a-SNCA*)2Mgsp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:219640 )

• in the Barnes maze, mice do not show a difference in latency to find the target hole across 5 days of testing, however they show an increase in the number of errors at days 3 and 4, indicating a partial learning impairment

abnormal spatial reference memory ( J:219640 )

• in the Barnes maze, mice show a deficit in their memory for the correct location of the target escape hole in the probe trial

abnormal response to novel object ( J:219640 )

• in the novel object recognition test, mice at 3 months of age spend less time exploring the novel object, which becomes more pronounced at 6 months of age

nervous system

alpha-synuclein inclusion body ( J:219640 )

• accumulation of the transgenic alpha-synuclein protein in the forebrain

taste/olfaction

impaired olfaction ( J:219640 )

• in the buried food test, mice show a slight but significant delay in the time spent to locate the food pellet at 1 month of age, but not at 3 or 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lewy body dementia		DOID:12217	OMIM:127750	J:219640