Snca^em3Hzo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Snca^em3Hzo
• Name: synuclein, alpha; endonuclease-mediated mutation 3, Huda Y Zoghbi
• MGI ID: MGI:8319110
• Synonyms: Snca^G51D
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^em3Hzo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Glycine codon 51 (GGA) was changed to aspartic acid (GAC) (p.G51D) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the same human mutation associated with Parkinson's Disease (PD). (J:354987)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 45 strains or lines available

References

• Original: J:354987 Kim Y, et al., Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2406479121
• All: 1 reference(s)