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Phenotypes Associated with This Genotype
Genotype
MGI:5543906
Allelic
Composition
Sncatm1Rosl/Sncatm1Rosl
Tg(SNCA*A30P)192Rwm/0
Genetic
Background
B6.Cg-Sncatm1Rosl Tg(SNCA*A30P)#Rwm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Rosl mutation (4 available); any Snca mutation (31 available)
Tg(SNCA*A30P)192Rwm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• aged mutants do not exhibit catecholaminergic neuron loss or alpha-synuclein neuropathology and show normal novelty-induced activity, forepaw stride length, activity on the accelerating rotarod, anxiety, immobility times in the tail suspension test, circadian rhythms, and spontaneous alternation in the T-maze
• mutants are more active in wheel running during the dark phase, however activity in locomotor cages is normal

homeostasis/metabolism
• electrically evoked release of dopamine is reduced in the caudate putamen, but not in the nucleus accumbens compared to single homozygous Sncatm1Rosl mutants, and show normal norepinephrine release in the stria terminalis

nervous system
• mutants are sensitive to the dopaminergic neurotoxin, MPTP, showing nigral and striatal damage, unlike single homozygous Sncatm1Rosl mutants which show resistance

digestive/alimentary system
N
• mutants appear to have normal gastrointestinal function as shown by normal stool water content, stool dry weight and stool frequency

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 1 DOID:0060367 OMIM:168601
J:201961


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory