Phenotypes Associated with This Genotype

Genotype
MGI:8319118

• Allelic Composition: Snca^em3Hzo/Snca^em3Hzo
• Genetic Background: C57BL/6J-Snca^em3Hzo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:354987 )

N • normal grip strength

N • normal latency to find visible food pellet

abnormal locomotor behavior ( J:354987 )

• increased central:total distance travelled ratio in open field test at age 12 months

• normal total distance traveled and speed in open field test

impaired limb coordination ( J:354987 )

• more footslips in parallel rod floor test

• shorter latency to fall in rotarod test at ages 9 and 12 months

abnormal gait ( J:354987 )

• slower average movement speed in catwalk assay at age 12 months

• more time with paws on ground in catwalk assay at age 12 months

• greater duty cycle (stance duration relative to step cycle duration) in catwalk assay at age 12 months

• longer terminal dual stance (length of time with both hind paws on ground) in catwalk assay at age 12 months

cellular

astrocytosis ( J:354987 )

• in motor and piriform cortex, striatum and reticular region of substantia nigra at age 12 months

microgliosis ( J:354987 )

• in motor and piriform cortex at age 12 months

digestive/alimentary system

abnormal defecation ( J:354987 )

• increased gut transit time at age 6 months

• less water in fecal pellets at ages 6 and 12 months

hematopoietic system

microgliosis ( J:354987 )

• in motor and piriform cortex at age 12 months

immune system

microgliosis ( J:354987 )

• in motor and piriform cortex at age 12 months

nervous system

astrocytosis ( J:354987 )

• in motor and piriform cortex, striatum and reticular region of substantia nigra at age 12 months

microgliosis ( J:354987 )

• in motor and piriform cortex at age 12 months

abnormal locus ceruleus morphology ( J:354987 )

• reduced noradrenergic neuron number at age 12 months

decreased dopaminergic neuron number ( J:354987 )

• in substantia nigra at age 12 months

taste/olfaction

impaired olfaction ( J:354987 )

• longer latency to find buried food pellet at age 6 months

• normal latency to find visible food pellet at age 6 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:354987