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Lepr Gene Detail
Summary
  • Symbol
    Lepr
  • Name
    leptin receptor
  • Synonyms
    Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:104993
    NCBI Gene: 16847
  • Gene Overview
    MyGene.info: LEPR
Location & Maps
more
  • Sequence Map
    Chr4:101717404-101815352 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      97949 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.96 cM
  • Mapping Data
    26 experiments
Homology
more
  • Human Ortholog
    LEPR, leptin receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LEPR, leptin receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD295, LEP-R, LEPRD, OBR, OB-R
  • Links
    NCBI Gene ID: 3953
    neXtProt AC: NX_P48357

  • Chr Location
    1p31; chr1:65420652-65637493 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Lepr mouse models; 1 with human LEPR associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 7 models
Obesity   OMIM: 601665 View 17 models
       Leptin Receptor Deficiency   OMIM: 614963
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    15 with disease annotations
  • References
    75 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    252 phenotypes from 40 alleles in 66 genetic backgrounds
    92 phenotypes from multigenic genotypes
    4 images
    1127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    53
  • Chemically induced (ENU)
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    15
  • Targeted
    23
  • Transgenic
    3
  • Genomic Mutations
    7 involving Lepr
  • Incidental Mutations
Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008454 VEGA Gene Model | MGI Sequence Detail 97949 C57BL/6J ±  kb
transcript OTTMUST00000019183 VEGA | MGI Sequence Detail 4127 Not Applicable  
polypeptide OTTMUSP00000008794 VEGA | MGI Sequence Detail 1162 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    618 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000001875 leptin receptor
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR010457 Immunoglobulin C2-set-like, ligand-binding
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR015752 Leptin receptor
    IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
    IPR003531 Short hematopoietin receptor, family 1, conserved site
Molecular
Reagents
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  • All nucleic 56
    Genomic 24
    cDNA 26
    Primer pair 5
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799
References
more
  • Summaries
    All 1288
    Developmental Gene Expression 19
    Diseases 75
    Gene Ontology 15
    Phenotypes 1127
  • Earliest
    J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50:290-292
  • Latest
    J:232421 Gonzalez S, et al., Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. J Clin Invest. 2016 Mar 1;126(3):1023-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory