Lepr
Gene Detail

Symbol Name ID

Lepr leptin receptor MGI:104993

Synonyms

Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP

Feature Type

protein coding gene

Genetic Map

Chromosome 4

46.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr4:101717404-101815352 bp, + strand From VEGA annotation of GRCm38   97949 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Lepr ± 2 cM)

Protein SuperFamily: leptin receptor
Gene Tree: Lepr

Human ortholog

LEPR leptin receptor NCBI Gene ID 3953
Human Synonyms: CD295, LEP-R, LEPRD, OBR, OB-R
Human Chr1:65886248-66103176 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human LEPR (1)

Alleles and phenotypes

All alleles(41) : Targeted(19) Transgenic(1) Spontaneous(14) Chemically induced(7)
 

Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting.

 
Human Diseases Modeled Using Mouse Lepr (3)    Alleles Annotated to Human Diseases(14)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	angiogenesis, cholesterol metabolic process, ...
Component	extracellular region, extracellular space, ...
Function	cytokine receptor activity, peptide hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (298)    Tissues (102)    Images (36)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	216
Northern blot	12
RT-PCR	70

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(24) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000008454 (Evidence)
Ensembl Gene Model	ENSMUSG00000057722 (Evidence)
Entrez Gene	16847 (Evidence)
DFCI	TC1582480, TC1586489, TC1590522, TC1641716
DoTS	DT.101348334, DT.101368835, DT.101368836, DT.110827087, DT.482434, DT.526088, DT.60101619, DT.91337499, DT.94184061
NIA Mouse Gene Index	U004553
Consensus CDS Project	CCDS18397.1, CCDS51239.1, CCDS51240.1
International Mouse Knockout Project Status	Lepr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008454	VEGA Gene Model | MGI Sequence Detail	97949	C57BL/6J
transcript	OTTMUST00000019183	VEGA | MGI Sequence Detail	4127	Not Applicable
polypeptide	OTTMUSP00000008794	VEGA | MGI Sequence Detail	1162	Not Applicable

All sequences(102) RefSeq(6) UniProt(7)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(371 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR010457	Immunoglobulin C2-set-like, ligand-binding
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015752	Leptin receptor
InterPro	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
InterPro	IPR003531	Short hematopoietin receptor, family 1, conserved site
Protein Ontology	PR:000001875	leptin receptor

References

(Earliest) J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50:290-292
(Latest) J:194102 Huh JY, et al., A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol Cell Biol. 2013 Jan;33(2):328-39
All references(937)

Other accession IDs

MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799