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Gene Detail
leptin receptor
Synonyms Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP
Feature Type protein coding gene
Genetic Map
Chromosome 4
46.96 cM
Detailed Genetic Map ± 1 cM

Mapping data(25)
Sequence Map
Chr4:101717404-101815352 bp, + strand
From VEGA annotation of GRCm38

  97949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: leptin receptor
Gene Tree: Lepr

Human Homolog LEPR, leptin receptor
NCBI Gene ID 3953
neXtProt AC  NX_P48357
Human Synonyms  CD295, LEP-R, LEPRD, OBR, OB-R
Human Chr (Location)  1p31; chr1:65420652-65637493 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LEPR
alleles, and
All mutations/alleles(42) : Chemically induced (ENU)(8) Spontaneous(14) Targeted(19) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting.
Human Diseases Modeled Using Mouse Lepr (3)    Alleles Annotated to Human Diseases(14)    Phenotype Images(4)
Lepr interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (25 annotations)
Process angiogenesis, cholesterol metabolic process, ...
Component extracellular region, extracellular space, ...
Function cytokine receptor activity, identical protein binding, ...
External Resources: FuncBase
Literature Summary: (17 records)
Data Summary: Results (298)    Tissues (102)    Images (38)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 216
Northern blot 12
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(56) Genomic(24) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000008454 (Evidence)
Ensembl Gene ModelENSMUSG00000057722 (Evidence)
Entrez Gene16847 (Evidence)
DFCITC1582480, TC1586489, TC1590522, TC1641716
DoTSDT.101348334, DT.101368835, DT.101368836, DT.110827087, DT.482434, DT.526088, DT.60101619, DT.91337499, DT.94184061
NIA Mouse Gene IndexU004553
Consensus CDS ProjectCCDS18397.1, CCDS51239.1, CCDS51240.1
International Mouse Knockout Project StatusLepr
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008454 VEGA Gene Model | MGI Sequence Detail 97949 C57BL/6J ±  kb
transcript OTTMUST00000019183 VEGA | MGI Sequence Detail 4127 Not Applicable 
polypeptide OTTMUSP00000008794 VEGA | MGI Sequence Detail 1162 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(6) UniProt(6)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(632 from dbSNP Build 137)
InterPro IPR003961 Fibronectin, type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015752 Leptin receptor
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001875 leptin receptor
References (Earliest) J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50:290-292
(Latest) J:212216 Cho YR, et al., Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice. PLoS One. 2014;9(1):e83204
All references(1119)
Disease annotation references (44)
accession IDs
MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory