About   Help   FAQ
Lepr
Gene Detail
Symbol

Name
ID
Lepr
leptin receptor
MGI:104993
Synonyms
Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP
Feature Type
protein coding gene
Genetic Map
Chromosome 4
46.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr4:101717404-101815352 bp, + strand
From VEGA annotation of GRCm38

  97949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LEPR
Protein SuperFamily: leptin receptor
Gene Tree: Lepr

Human
homologs
LEPR, leptin receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3953
neXtProt AC: NX_P48357

Human Synonyms: CD295, LEP-R, LEPRD, OBR, OB-R

Human Chr (Location): 1p31; chr1:65420652-65637493 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LEPR

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Chemically induced (ENU)(9) Spontaneous(14) Targeted(20) Transgenic(1)
Genomic Mutations involving Lepr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting.
 
Human Diseases Modeled in Mice Using Lepr (2)    Mutations Annotated to Human Diseases (15)    Phenotype Images(4)
Interactions
Lepr interacts with 349 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process angiogenesis, cholesterol metabolic process, ...
Component extracellular region, extracellular space, ...
Function cytokine receptor activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (298)    Tissues (102)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 216
Northern blot 12
RT-PCR 70
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lepr ; ZFIN lepr    NEW 
Molecular
reagents
All nucleic(56) Genomic(24) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000008454 (Evidence)
Ensembl Gene Model ENSMUSG00000057722 (Evidence)
Entrez Gene 16847 (Evidence)
DFCI TC1582480, TC1641716, TC1590522, TC1586489
DoTS DT.110827087, DT.101368836, DT.101368835, DT.101348334, DT.526088, DT.482434, DT.60101619, DT.94184061, DT.91337499
NIA Mouse Gene Index U004553
Consensus CDS Project CCDS18397.1, CCDS51239.1, CCDS51240.1
International Mouse Phenotyping Consortium Status Lepr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008454 VEGA Gene Model | MGI Sequence Detail 97949 C57BL/6J ±  kb
transcript OTTMUST00000019183 VEGA | MGI Sequence Detail 4127 Not Applicable 
polypeptide OTTMUSP00000008794 VEGA | MGI Sequence Detail 1162 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(6) UniProt(6)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(632 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015752 Leptin receptor
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001875 leptin receptor
References
(Earliest) J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50:290-292
(Latest) J:222171 Cheung SY, et al., Activation of transient receptor potential vanilloid 3 channel suppresses adipogenesis. Endocrinology. 2015 Jun;156(6):2074-86
All references(1200)
Disease annotation references (54)
Other
accession IDs
MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory