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Lepr
Gene Detail
 Symbol
Name
ID
Lepr
leptin receptor
MGI:104993
Synonyms Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP
Feature Type protein coding gene
Genetic Map
Chromosome 4
46.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr4:101717404-101815352 bp, + strand
From VEGA annotation of GRCm38

  97949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leptin receptor
Gene Tree: Lepr

Human
homologs
Human Homolog LEPR, leptin receptor
NCBI Gene ID 3953
neXtProt AC  NX_P48357
Human Synonyms  CD295, LEP-R, LEPRD, OBR, OB-R
Human Chr (Location)  1p31; chr1:65420652-65637493 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LEPR
Alleles
and
phenotypes
All alleles(41) : Targeted(19) Transgenic(1) Spontaneous(14) Chemically induced(7)
 
Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting.
 
Human Diseases Modeled Using Mouse Lepr (3)    Alleles Annotated to Human Diseases(14)    Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process angiogenesis, cholesterol metabolic process, ...
Component extracellular region, extracellular space, ...
Function cytokine receptor activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (298)    Tissues (102)    Images (38)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 216
Northern blot 12
RT-PCR 70
cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(56) Genomic(24) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000008454 (Evidence)
Ensembl Gene ModelENSMUSG00000057722 (Evidence)
Entrez Gene16847 (Evidence)
DFCITC1582480, TC1586489, TC1590522, TC1641716
DoTSDT.101348334, DT.101368835, DT.101368836, DT.110827087, DT.482434, DT.526088, DT.60101619, DT.91337499, DT.94184061
NIA Mouse Gene IndexU004553
Consensus CDS ProjectCCDS18397.1, CCDS51239.1, CCDS51240.1
International Mouse Knockout Project StatusLepr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008454 VEGA Gene Model | MGI Sequence Detail 97949 C57BL/6J ±  kb
transcript OTTMUST00000019183 VEGA | MGI Sequence Detail 4127 Not Applicable 
polypeptide OTTMUSP00000008794 VEGA | MGI Sequence Detail 1162 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(6) UniProt(6)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(632 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015752 Leptin receptor
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001875 leptin receptor
References (Earliest) J:31691 Falconer DS, et al., Adipose, a new inherited obesity of the mouse. J Hered. 1959;50:290-292
(Latest) J:207097 Saucillo DC, et al., Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol. 2014 Jan 1;192(1):136-44
All references(1051)
Other
accession IDs
MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory