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Stat3 Gene Detail
Summary
  • Symbol
    Stat3
  • Name
    signal transducer and activator of transcription 3
  • Synonyms
    1110034C02Rik, Aprf
  • Feature Type
    protein coding gene
  • IDs
    MGI:103038
    NCBI Gene: 20848
  • Gene Overview
    MyGene.info: STAT3
Location & Maps
more
  • Sequence Map
    Chr11:100885098-100939540 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54443 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STAT3, signal transducer and activator of transcription 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAT3, signal transducer and activator of transcription 3
    Orthology source: HomoloGene
  • Synonyms
    ADMIO, APRF, HIES
  • Links
    NCBI Gene ID: 6774
    neXtProt AC: NX_P40763

  • Chr Location
    17q21.31; chr17:42313324-42388503 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Stat3 mouse models; 2 with human STAT3 associations

Human Disease Mouse Models
       Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant   OMIM: 147060 View 1 model
       Autoimmune Disease, Multisystem, Infantile-Onset; ADMIO   OMIM: 615952
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    195 phenotypes from 17 alleles in 26 genetic backgrounds
    29 phenotypes from multigenic genotypes
    7 images
    367 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Gene trapped
    37
  • Targeted
    24
  • Transgenic
    2
  • Genomic Mutations
    1 involving Stat3
  • Incidental Mutations
Homozygotes for targeted null mutations die at embryonic day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002128 VEGA Gene Model | MGI Sequence Detail 54443 C57BL/6J ±  kb
transcript OTTMUST00000004321 VEGA | MGI Sequence Detail 4516 Not Applicable  
polypeptide OTTMUSP00000002052 VEGA | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    252 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000002089 signal transducer and activator of transcription 3
  • PDB
  • InterPro Domains
    IPR011992 EF-hand domain pair
    IPR008967 p53-like transcription factor, DNA-binding
    IPR000980 SH2 domain
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, subdomain
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
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  • All nucleic 374
    Genomic 2
    cDNA 367
    Primer pair 5

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-23900, MGI:1915983, MGI:2144497
References
more
  • Summaries
    All 631
    Developmental Gene Expression 67
    Diseases 1
    Gene Ontology 50
    Phenotypes 367
  • Earliest
    J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
  • Latest
    J:228206 Hos D, et al., IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages. Am J Pathol. 2016 Jan;186(1):159-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory