Stat3
Gene Detail

Symbol Name ID

Stat3 signal transducer and activator of transcription 3 MGI:103038

Synonyms

1110034C02Rik, Aprf

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:100885098-100939540 bp, - strand From VEGA annotation of GRCm38   54443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat3

Human homologs

Human Homolog		STAT3, signal transducer and activator of transcription 3 (acute-phase response factor)
NCBI Gene ID		6774
neXtProt AC		NX_P40763
Human Synonyms		APRF, HIES
Human Chr (Location)		17q21.31; chr17:40465343-40540513 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STAT3

Alleles and phenotypes

All alleles(53) : Targeted(16) Gene trapped(37)
 

Homozygotes for targeted null mutations die at embryonic day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility.

 
Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	acute-phase response, astrocyte differentiation, ...
Component	cytoplasm, nucleus, ...
Function	calcium ion binding, CCR5 chemokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (49 records)
Data Summary: Results (415)    Tissues (184)    Images (102)
Theiler Stages: 2, 3, 4, 5, 7, 9, 17, 18, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	39
RNA in situ	254
Western blot	6
RT-PCR	116

cDNA source data(360)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(369) Genomic(2) cDNA(362) Primer pair(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000002128 (Evidence)
Ensembl Gene Model	ENSMUSG00000004040 (Evidence)
Entrez Gene	20848 (Evidence)
UniGene	249934
DFCI	TC1572239, TC1588353, TC1599527, TC1640767, TC1707201
NIA Mouse Gene Index	U033438
PDB	3CWG, 1BG1, 4E68
Consensus CDS Project	CCDS25440.1, CCDS25441.1, CCDS48934.1
International Mouse Knockout Project Status	Stat3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002128	VEGA Gene Model | MGI Sequence Detail	54443	C57BL/6J
transcript	OTTMUST00000004321	VEGA | MGI Sequence Detail	4516	Not Applicable
polypeptide	OTTMUSP00000002052	VEGA | MGI Sequence Detail	770	Not Applicable

All sequences(87) RefSeq(6) UniProt(7)

Polymorphisms

RFLP(2) : SNPs(138 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR000980	SH2 domain
InterPro	IPR013800	STAT transcription factor, all-alpha
InterPro	IPR015988	STAT transcription factor, coiled coil
InterPro	IPR001217	STAT transcription factor, core
InterPro	IPR013801	STAT transcription factor, DNA-binding
InterPro	IPR012345	STAT transcription factor, DNA-binding, subdomain
InterPro	IPR013799	STAT transcription factor, protein interaction
Protein Ontology	PR:000002089	signal transducer and activator of transcription 3

References

(Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:196394 Zhang H, et al., IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest. 2013 Mar 1;123(3):1019-31
All references(494)

Other accession IDs

MGD-MRK-23900, MGI:1915983, MGI:2144497