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Gene Detail
signal transducer and activator of transcription 3
Synonyms 1110034C02Rik, Aprf
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.82 cM
Detailed Genetic Map ± 1 cM

Mapping data(8)
Sequence Map
Chr11:100885098-100939540 bp, - strand
From VEGA annotation of GRCm38

  54443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:7960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat3

Human Homolog STAT3, signal transducer and activator of transcription 3 (acute-phase response factor)
NCBI Gene ID 6774
neXtProt AC  NX_P40763
Human Synonyms  APRF, HIES
Human Chr (Location)  17q21.31; chr17:42313324-42388568 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human STAT3
alleles, and
All mutations/alleles(55) : Gene trapped(37) Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for targeted null mutations die at embryonic day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility.
Phenotype Images(7)
Stat3 interacts with 400 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
All GO classifications: (87 annotations)
Process acute-phase response, astrocyte differentiation, ...
Component cytoplasm, intracellular, ...
Function CCR5 chemokine receptor binding, DNA binding, ...
External Resources: FuncBase
Literature Summary: (57 records)
Data Summary: Results (524)    Tissues (247)    Images (134)
Theiler Stages: 2, 3, 4, 5, 7, 9, 17, 18, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 85
RNA in situ 254
Western blot 76
RT-PCR 109
cDNA source data(364)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(373) Genomic(2) cDNA(366) Primer pair(5)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000002128 (Evidence)
Ensembl Gene ModelENSMUSG00000004040 (Evidence)
Entrez Gene20848 (Evidence)
DFCITC1572239, TC1588353, TC1599527, TC1640767, TC1707201
NIA Mouse Gene IndexU033438
PDB3CWG, 1BG1, 4E68
Consensus CDS ProjectCCDS25440.1, CCDS25441.1, CCDS48934.1
International Mouse Knockout Project StatusStat3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002128 VEGA Gene Model | MGI Sequence Detail 54443 C57BL/6J ±  kb
transcript OTTMUST00000004321 VEGA | MGI Sequence Detail 4516 Not Applicable 
polypeptide OTTMUSP00000002052 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(6) UniProt(7)
Polymorphisms RFLP(2) : SNPs within 2kb(252 from dbSNP Build 137)
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002089 signal transducer and activator of transcription 3
References (Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:211829 Priceman SJ, et al., S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. Cell Rep. 2014 Mar 27;6(6):992-9
All references(557)
accession IDs
MGD-MRK-23900, MGI:1915983, MGI:2144497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory