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Stat3
Gene Detail
Symbol

Name
ID
Stat3
signal transducer and activator of transcription 3
MGI:103038
Synonyms
1110034C02Rik, Aprf
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:100885098-100939540 bp, - strand
From VEGA annotation of GRCm38

  54443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STAT3
Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat3

Human
homologs
STAT3, signal transducer and activator of transcription 3 (acute-phase response factor)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6774
neXtProt AC: NX_P40763

Human Synonyms: ADMIO, APRF, HIES

Human Chr (Location): 17q21.31; chr17:42313324-42388503 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human STAT3

Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(37) Targeted(22) Transgenic(1)
Genomic Mutations involving Stat3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die at embryonic day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility.
 
Human Diseases Modeled in Mice Using Stat3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Interactions
Stat3 interacts with 399 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (100 annotations)
Process acute-phase response, astrocyte differentiation, ...
Component cytoplasm, intracellular, ...
Function CCR5 chemokine receptor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (524)    Tissues (247)    Images (134)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 85
RNA in situ 254
Western blot 76
RT-PCR 109
cDNA source data(364)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498547, stat3 ; ZFIN stat3    NEW 
Molecular
reagents
All nucleic(373) Genomic(2) cDNA(366) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000002128 (Evidence)
Ensembl Gene Model ENSMUSG00000004040 (Evidence)
Entrez Gene 20848 (Evidence)
UniGene 249934
DFCI TC1572239, TC1588353, TC1599527, TC1640767, TC1707201
NIA Mouse Gene Index U033438
PDB 1BG1, 3CWG, 4E68
Consensus CDS Project CCDS25440.1, CCDS25441.1, CCDS48934.1
International Mouse Phenotyping Consortium Status Stat3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002128 VEGA Gene Model | MGI Sequence Detail 54443 C57BL/6J ±  kb
transcript OTTMUST00000004321 VEGA | MGI Sequence Detail 4516 Not Applicable 
polypeptide OTTMUSP00000002052 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(252 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002089 signal transducer and activator of transcription 3
References
(Earliest) J:18621 Zhong Z, et al., Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4806-10
(Latest) J:222468 Kleppe M, et al., JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response. Cancer Discov. 2015 Mar;5(3):316-31
All references(600)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-23900, MGI:1915983, MGI:2144497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory