Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 9.0.0)

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and protein sequestering activity. Involved in several processes, including cell surface receptor signaling pathway; glial cell differentiation; and lymphocyte activation involved in immune response. Acts upstream of or within several processes, including mRNA transcription by RNA polymerase II; negative regulation of glycolytic process; and negative regulation of neuron migration. Located in plasma membrane. Part of transcription regulator complex. Is active in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hindlimb long bone. Used to study autosomal dominant hyper-IgE syndrome 1 with recurrent infections; colorectal cancer; inflammatory bowel disease; peripartum cardiomyopathy; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; arthritis (multiple); carcinoma (multiple); inflammatory bowel disease (multiple); and reproductive organ cancer (multiple). Orthologous to human STAT3 (signal transducer and activator of transcription 3).

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Gene Ontology Evidence Code Abbreviations:

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