Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Axin1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AXIN1
- Mouse genes Axin1
- Rat genes Axin1
- Zfish genes axin1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Axin1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070016	armadillo repeat domain binding	Axin1	IDA		Rat	PMID:9482734\|RGD:632259
Molecular Function	GO:0008013	beta-catenin binding	AXIN1	IDA		Human	PMID:10644691
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IPI	PR:Q02248	Mouse	PMID:10318824
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IPI	PR:Q02248	Mouse	PMID:18632848
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IPI	UniProtKB:P35222	Mouse	PMID:10330403
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IPI	UniProtKB:Q9WU82	Rat	PMID:10330181\|RGD:4108508
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IPI	RGD:70487	Rat	PMID:15228590\|RGD:1304344
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IPI	UniProtKB:P35222	Rat	PMID:16890161\|RGD:8554078
Molecular Function	GO:0008013	beta-catenin binding	Axin1	IDA		Rat	PMID:9482734\|RGD:632259
Molecular Function	GO:0019899	enzyme binding	AXIN1	IPI	UniProtKB:O95271	Human	PMID:19759537
Molecular Function	GO:0019899	enzyme binding	AXIN1	IPI	UniProtKB:Q9H2K2	Human	PMID:19759537
Molecular Function	GO:0019899	enzyme binding	AXIN1	IPI	UniProtKB:Q70CQ2	Human	PMID:21383061
Molecular Function	GO:0019899	enzyme binding	AXIN1	IPI	UniProtKB:O95271	Human	PMID:21478859
Molecular Function	GO:0019899	enzyme binding	AXIN1	IPI	UniProtKB:Q9H2K2	Human	PMID:21478859
Molecular Function	GO:0070411	I-SMAD binding	AXIN1	IPI	UniProtKB:O15105	Human	PMID:16601693
Molecular Function	GO:0070411	I-SMAD binding	AXIN1	IPI	UniProtKB:O15105	Human	PMID:18593713
Molecular Function	GO:0070411	I-SMAD binding	Axin1	IDA		Mouse	MGI:MGI:3628833\|PMID:16601693
Molecular Function	GO:0070411	I-SMAD binding	Axin1	IPI	PR:O35253	Mouse	PMID:16601693
Molecular Function	GO:0070411	I-SMAD binding	Axin1	IPI	PR:O35182	Mouse	PMID:16601693
Molecular Function	GO:0042802	identical protein binding	AXIN1	IPI	UniProtKB:O15169	Human	PMID:10811618
Molecular Function	GO:0042802	identical protein binding	AXIN1	IPI	UniProtKB:O15169	Human	PMID:16169070
Molecular Function	GO:0042802	identical protein binding	AXIN1	IPI	UniProtKB:O15169	Human	PMID:21245303
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	PR:O35625	Mouse	PMID:9920888
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	PR:O35625	Mouse	PMID:10318824
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	PR:O35625	Mouse	PMID:15579909
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	PR:O35625	Mouse	PMID:18632848
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	RGD:620859	Rat	PMID:10330181\|RGD:4108508
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	UniProtKB:O70239	Rat	PMID:10330181\|RGD:4108508
Molecular Function	GO:0042802	identical protein binding	Axin1	IPI	UniProtKB:O70239	Rat	PMID:17529994\|RGD:13432324
Molecular Function	GO:0060090	molecular adaptor activity	AXIN1	IMP		Human	PMID:16601693
Molecular Function	GO:0060090	molecular adaptor activity	AXIN1	IDA		Human	PMID:9601641
Molecular Function	GO:0060090	molecular adaptor activity	Axin1	IMP		Mouse	MGI:MGI:3628833\|PMID:16601693
Molecular Function	GO:0002039	p53 binding	Axin1	IPI	PR:P02340	Mouse	PMID:15526030
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:G1T8E2	Human	PMID:10481074
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:10481074
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35813	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P25054	Human	PMID:10811618
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:11738041
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P70331-2	Human	PMID:12192039
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9P1T7	Human	PMID:12192039
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P39687	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q14194	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q02248	Human	PMID:16293619
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O15105	Human	PMID:16601693
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q6ZNA4	Human	PMID:16601693
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q99ML9	Human	PMID:16601693
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49840	Human	PMID:17318175
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P62136	Human	PMID:17318175
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:17318191
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:17318191
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P25054	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49840	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q5JTC6	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9H7D7	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q96EY1	Human	PMID:17588722
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:17601533
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P70039	Human	PMID:18786926
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P01106	Human	PMID:19131971
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P25054	Human	PMID:19131971
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:19131971
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:19166851
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49407	Human	PMID:19202075
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:19202075
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q14134	Human	PMID:19249679
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:19303846
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P23258	Human	PMID:19390532
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:19759537
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q5VWQ8-2	Human	PMID:20080667
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P04637	Human	PMID:21057547
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:21242974
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:21242974
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O14641	Human	PMID:21245303
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49674	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9H2K2	Human	PMID:22153077
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P25054	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49674	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q5JTC6	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9UKB1	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O14641	Human	PMID:22773187
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:22773187
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:22773187
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49840	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:24976009
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P46937	Human	PMID:24976009
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:24976009
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q15583	Human	PMID:25873176
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P14923	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P25054	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49674	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q5JTC6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:G2XKQ0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O43586	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O75558	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O94972	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P14373	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P14923	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P63165	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q08379	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q12933	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q13137	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q15654	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q2TAC2-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q5JR59-3	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q6A162	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q6FHY5	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q969G2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q96K21-3	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q96KG9-4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q99750	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9BQ66	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9BYR5	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9C019	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9H257-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9HCK0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9UBB9	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9UJV3-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9H7D7	Human	PMID:27098453
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:27484798
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:O43255	Human	PMID:28546513
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q8IUQ4	Human	PMID:28546513
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222\|UniProtKB:P49841	Human	PMID:28829046
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q9NWU2	Human	PMID:28829046
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P25054	Human	PMID:9601641
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P35222	Human	PMID:9601641
Molecular Function	GO:0005515	protein binding	AXIN1	IPI	UniProtKB:P49841	Human	PMID:9601641
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4839454\|PMID:12897152
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q6PFX9	Mouse	MGI:MGI:5314424\|PMID:22307604
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O75197	Mouse	MGI:MGI:4818258\|PMID:11336703
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P49841\|UniProtKB:Q9JIF0-1\|UniProtKB:Q9JIF0-3\|UniProtKB:Q9JIF0	Mouse	MGI:MGI:5306548\|PMID:21242974
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4839439\|PMID:19107203
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P49841	Mouse	MGI:MGI:4943616\|PMID:20368287
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q15583	Mouse	MGI:MGI:5634198\|PMID:25873176
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P49841	Mouse	MGI:MGI:5437379\|PMID:22682247
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P98078\|UniProtKB:Q61062	Mouse	MGI:MGI:2664441\|PMID:12805222
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O95271	Mouse	MGI:MGI:5298339\|PMID:19759537
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P46937\|UniProtKB:Q9EPK5	Mouse	MGI:MGI:5603220\|PMID:24976009
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P62137\|UniProtKB:P98078	Mouse	MGI:MGI:5516186\|PMID:19581931
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q60953-2	Mouse	MGI:MGI:5315336\|PMID:21057547
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q9PTP2	Mouse	MGI:MGI:3700435\|PMID:10688669
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O35182\|UniProtKB:O35253\|UniProtKB:Q8BUN5\|UniProtKB:Q99ML9	Mouse	MGI:MGI:3628833\|PMID:16601693
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P35222	Mouse	MGI:MGI:4462743\|PMID:20531388
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P35222\|UniProtKB:P49841	Mouse	MGI:MGI:5582179\|PMID:12421363
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:P51141	Mouse	PMID:11113207
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q9QXZ0	Mouse	PMID:16815997
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:P53349	Mouse	PMID:12878610
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:O08648	Mouse	PMID:12878610
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:P51141	Mouse	PMID:17681137
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q02248	Mouse	PMID:15327768
Molecular Function	GO:0005515	protein binding	Axin1	IDA		Mouse	PMID:10318824
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q60838	Mouse	PMID:15579909
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q8C4Q6	Mouse	PMID:17681137
Molecular Function	GO:0005515	protein binding	Axin1	IPI	MGI:MGI:1346872	Mouse	PMID:17681137
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q91VN0	Mouse	PMID:19075000
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:P63330	Mouse	PMID:9920888
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q80Y83	Mouse	PMID:15579909
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q91VN0	Mouse	PMID:18632848
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q9WV60	Mouse	PMID:18632848
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:Q9D0L1	Mouse	PMID:19141611
Molecular Function	GO:0005515	protein binding	Axin1	IPI	PR:O08648	Mouse	PMID:17681137
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:D4ADV8	Rat	PMID:10330181\|RGD:4108508
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O14640	Rat	PMID:10330181\|RGD:4108508
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q92997	Rat	PMID:10330181\|RGD:4108508
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O14640	Rat	PMID:11113207\|RGD:68802
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O14640	Rat	PMID:11425858\|RGD:8553771
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P49674	Rat	PMID:11425858\|RGD:8553771
Molecular Function	GO:0005515	protein binding	Axin1	IPI	RGD:621855	Rat	PMID:15228590\|RGD:1304344
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:D3ZHV2	Rat	PMID:16815997\|RGD:8553932
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O75581	Rat	PMID:16890161\|RGD:8554078
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:P49841	Rat	PMID:16890161\|RGD:8554078
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q03135	Rat	PMID:16890161\|RGD:8554078
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:O75581	Rat	PMID:21304492\|RGD:8554596
Molecular Function	GO:0005515	protein binding	Axin1	IPI	UniProtKB:Q9Y4X0	Rat	PMID:21304492\|RGD:8554596
Molecular Function	GO:0005515	protein binding	axin1	IPI	UniProtKB:E9QDC5	Zfish	PMID:30467143\|ZFIN:ZDB-PUB-181127-52
Molecular Function	GO:0019904	protein domain specific binding	Axin1	IPI	PR:Q60838	Mouse	PMID:15579909
Molecular Function	GO:0019904	protein domain specific binding	Axin1	IPI	PR:Q8C4Q6	Mouse	PMID:17681137
Molecular Function	GO:0019904	protein domain specific binding	Axin1	IPI	RGD:708378	Rat	PMID:10944533\|RGD:1299408
Molecular Function	GO:0042803	protein homodimerization activity	Axin1	IPI	UniProtKB:O35625	Mouse	MGI:MGI:3799599\|PMID:17681137
Molecular Function	GO:0019901	protein kinase binding	Axin1	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5440351\|PMID:22899650
Molecular Function	GO:0019901	protein kinase binding	Axin1	IPI	UniProtKB:P49841	Mouse	PMID:10318824
Molecular Function	GO:0019901	protein kinase binding	Axin1	IPI	PR:Q9QZR5	Mouse	PMID:15526030
Molecular Function	GO:0019901	protein kinase binding	Axin1	IPI	UniProtKB:P18266	Rat	PMID:10228155\|RGD:8553327
Molecular Function	GO:0043621	protein self-association	Axin1	IPI	PR:O35625	Mouse	PMID:15579909
Molecular Function	GO:0070412	R-SMAD binding	Axin1	IPI	PR:Q8BUN5	Mouse	PMID:16601693
Molecular Function	GO:0005102	signaling receptor binding	Axin1	IPI	UniProtKB:O75581	Rat	PMID:16890161\|RGD:8554078
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	AXIN1	IMP		Human	PMID:16601693
Molecular Function	GO:0046332	SMAD binding	AXIN1	IPI	UniProtKB:O15105	Human	PMID:18593713
Molecular Function	GO:0031625	ubiquitin protein ligase binding	AXIN1	IPI	UniProtKB:Q6ZNA4	Human	PMID:16601693
Molecular Function	GO:0031625	ubiquitin protein ligase binding	AXIN1	IPI	UniProtKB:Q9NTX7	Human	PMID:21478859
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Axin1	IPI	PR:Q99ML9	Mouse	PMID:16601693
Cellular Component	GO:0030877	beta-catenin destruction complex	AXIN1	IDA		Human	PMID:16188939
Cellular Component	GO:0030877	beta-catenin destruction complex	AXIN1	IDA		Human	PMID:19759537
Cellular Component	GO:0030877	beta-catenin destruction complex	AXIN1	IDA		Human	PMID:9601641
Cellular Component	GO:0030877	beta-catenin destruction complex	Axin1	IDA		Mouse	PMID:10318824
Cellular Component	GO:0030877	beta-catenin destruction complex	Axin1	IDA		Rat	PMID:10228155\|RGD:8553327
Cellular Component	GO:0030877	beta-catenin destruction complex	axin1	IDA		Zfish	PMID:11390362
Cellular Component	GO:0005938	cell cortex	Axin1	IDA		Mouse	PMID:10330403
Cellular Component	GO:0071944	cell periphery	AXIN1	IDA		Human	PMID:19038973
Cellular Component	GO:0005737	cytoplasm	AXIN1	IDA		Human	PMID:12072559
Cellular Component	GO:0005737	cytoplasm	AXIN1	IDA		Human	PMID:17569865
Cellular Component	GO:0005737	cytoplasm	AXIN1	IDA		Human	PMID:21383061
Cellular Component	GO:0005737	cytoplasm	Axin1	IDA		Mouse	MGI:MGI:3628833\|PMID:16601693
Cellular Component	GO:0005737	cytoplasm	Axin1	IDA		Mouse	PMID:18606656
Cellular Component	GO:0005737	cytoplasm	Axin1	IDA		Mouse	PMID:11113207
Cellular Component	GO:0031410	cytoplasmic vesicle	Axin1	IDA		Mouse	PMID:11113207
Cellular Component	GO:0031410	cytoplasmic vesicle	Axin1	IDA		Rat	PMID:11113207\|RGD:68802
Cellular Component	GO:0005794	Golgi apparatus	Axin1	IDA		Rat	PMID:16890161\|RGD:8554078
Cellular Component	GO:0016328	lateral plasma membrane	AXIN1	IDA		Human	PMID:12072559
Cellular Component	GO:0015630	microtubule cytoskeleton	Axin1	IDA		Mouse	PMID:14734535
Cellular Component	GO:0005634	nucleus	AXIN1	IDA		Human	PMID:12072559
Cellular Component	GO:0005634	nucleus	AXIN1	IDA		Human	PMID:21383061
Cellular Component	GO:0048471	perinuclear region of cytoplasm	AXIN1	IDA		Human	PMID:19038973
Cellular Component	GO:0005886	plasma membrane	Axin1	IDA		Mouse	MGI:MGI:5805369\|PMID:12138115
Cellular Component	GO:0005886	plasma membrane	Axin1	IDA		Mouse	MGI:MGI:3640889\|PMID:16815997
Cellular Component	GO:0005886	plasma membrane	Axin1	IDA		Mouse	PMID:10330403
Cellular Component	GO:0005886	plasma membrane	Axin1	IDA		Rat	PMID:15228590\|RGD:1304344
Cellular Component	GO:0005886	plasma membrane	Axin1	IDA		Rat	PMID:16815997\|RGD:8553932
Cellular Component	GO:0005886	plasma membrane	Axin1	IDA		Rat	PMID:16890161\|RGD:8554078
Cellular Component	GO:0014069	postsynaptic density	Axin1	IDA		Rat	PMID:15228590\|RGD:1304344
Cellular Component	GO:0032991	protein-containing complex	Axin1	IDA		Mouse	PMID:16601693
Cellular Component	GO:0045202	synapse	Axin1	IDA		Rat	PMID:15228590\|RGD:1304344
Cellular Component	GO:1990909	Wnt signalosome	Axin1	IDA		Mouse	MGI:MGI:5440351\|PMID:22899650
Biological Process	GO:0032147	activation of protein kinase activity	AXIN1	IDA		Human	PMID:9601641
Biological Process	GO:0007628	adult walking behavior	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0048318	axial mesoderm development	Axin1	IMP	MGI:MGI:1857546	Mouse	PMID:9230313
Biological Process	GO:0048320	axial mesoderm formation	Axin1	IMP	MGI:MGI:1857546	Mouse	PMID:9230313
Biological Process	GO:0060070	canonical Wnt signaling pathway	Axin1	IMP		Mouse	PMID:19075000
Biological Process	GO:0060070	canonical Wnt signaling pathway	Axin1	IDA		Mouse	PMID:10937998
Biological Process	GO:0031122	cytoplasmic microtubule organization	Axin1	IGI	MGI:MGI:94941	Mouse	PMID:14734535
Biological Process	GO:0007368	determination of left/right symmetry	axin1	IMP	ZFIN:ZDB-GENO-071128-3	Zfish	PMID:17678853
Biological Process	GO:0009950	dorsal/ventral axis specification	Axin1	IDA		Mouse	PMID:10330403
Biological Process	GO:0009950	dorsal/ventral axis specification	axin1	IDA		Zfish	PMID:17681137\|ZFIN:ZDB-PUB-070813-12
Biological Process	GO:0009953	dorsal/ventral pattern formation	Axin1	IMP	MGI:MGI:1856035	Mouse	PMID:18316368
Biological Process	GO:0009953	dorsal/ventral pattern formation	axin1	IMP		Zfish	PMID:17681137\|ZFIN:ZDB-PUB-070813-12
Biological Process	GO:0009953	dorsal/ventral pattern formation	axin1	IDA		Zfish	PMID:17681137
Biological Process	GO:0009953	dorsal/ventral pattern formation	axin1	IDA		Zfish	PMID:10704853
Biological Process	GO:0048048	embryonic eye morphogenesis	axin1	IMP	ZFIN:ZDB-GENO-071128-3	Zfish	PMID:18356958
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	Axin1	IMP	MGI:MGI:1856036	Mouse	MGI:MGI:48782
Biological Process	GO:0034101	erythrocyte homeostasis	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0001654	eye development	axin1	IMP	ZFIN:ZDB-GENO-020715-4	Zfish	PMID:16854974
Biological Process	GO:0001654	eye development	axin1	IGI	ZFIN:ZDB-GENO-020715-4	Zfish	PMID:16854974
Biological Process	GO:0031101	fin regeneration	axin1	IMP	ZFIN:ZDB-GENO-070403-1	Zfish	PMID:17185322
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	axin1	IMP	ZFIN:ZDB-GENO-020715-4	Zfish	PMID:11390362
Biological Process	GO:0030900	forebrain development	axin1	IMP	ZFIN:ZDB-GENO-980202-966	Zfish	PMID:9007240
Biological Process	GO:0021877	forebrain neuron fate commitment	axin1	IMP	ZFIN:ZDB-GENO-980202-966	Zfish	PMID:9010204
Biological Process	GO:0071514	genomic imprinting	Axin1	IMP	MGI:MGI:1856035	Mouse	PMID:12601169
Biological Process	GO:0060322	head development	Axin1	IMP	MGI:MGI:4941943	Mouse	PMID:21344612
Biological Process	GO:0020027	hemoglobin metabolic process	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0001701	in utero embryonic development	Axin1	IGI	MGI:MGI:88276	Mouse	PMID:19204372
Biological Process	GO:0001701	in utero embryonic development	Axin1	IMP	MGI:MGI:3840238	Mouse	PMID:19204372
Biological Process	GO:0001701	in utero embryonic development	Axin1	IMP	MGI:MGI:3840236	Mouse	PMID:19204372
Biological Process	GO:0001743	lens placode formation	axin1	IMP	ZFIN:ZDB-GENO-980202-966	Zfish	PMID:9007240
Biological Process	GO:0055001	muscle cell development	axin1	IGI	ZFIN:ZDB-GENO-100719-1	Zfish	PMID:19517013
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AXIN1	IDA		Human	PMID:10644691
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AXIN1	IMP		Human	PMID:22899650
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Axin1	IDA		Mouse	PMID:19204372
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Axin1	IDA		Mouse	PMID:15579909
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Axin1	IDA		Rat	PMID:9482734\|RGD:632259
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	axin1	IGI	ZFIN:ZDB-GENO-100719-1	Zfish	PMID:19517013
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	axin1	IMP	ZFIN:ZDB-GENO-980202-966	Zfish	PMID:11641213
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Axin1	IDA		Mouse	PMID:10937998
Biological Process	GO:0010629	negative regulation of gene expression	Axin1	IDA		Mouse	PMID:18076571
Biological Process	GO:0051248	negative regulation of protein metabolic process	Axin1	IDA		Mouse	PMID:10330403
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Axin1	IDA		Mouse	PMID:19204372
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Axin1	IDA		Mouse	PMID:10318824
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Axin1	IDA		Mouse	PMID:17681137
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Axin1	IDA		Mouse	PMID:9230313
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Axin1	IDA		Mouse	PMID:12717450
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	axin1	IMP	ZFIN:ZDB-GENO-020715-4	Zfish	PMID:11390362
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	axin1	IMP	ZFIN:ZDB-GENO-020715-4	Zfish	PMID:15539488
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	axin1	IDA		Zfish	PMID:30467143\|ZFIN:ZDB-PUB-181127-52
Biological Process	GO:0050877	nervous system process	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0021999	neural plate anterior/posterior regionalization	axin1	IMP	ZFIN:ZDB-GENO-980202-966	Zfish	PMID:11641213
Biological Process	GO:0021999	neural plate anterior/posterior regionalization	axin1	IMP	ZFIN:ZDB-GENO-020715-4	Zfish	PMID:11390362
Biological Process	GO:0060896	neural plate pattern specification	axin1	IMP	ZFIN:ZDB-GENO-121005-2	Zfish	PMID:22957046
Biological Process	GO:0060896	neural plate pattern specification	axin1	IMP	ZFIN:ZDB-MRPHLNO-080326-3	Zfish	PMID:22957046
Biological Process	GO:0006913	nucleocytoplasmic transport	Axin1	IDA		Mouse	PMID:14981260
Biological Process	GO:0030910	olfactory placode formation	axin1	IMP	ZFIN:ZDB-GENO-980202-966	Zfish	PMID:9007240
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	AXIN1	IMP		Human	PMID:16601693
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Axin1	IDA		Mouse	MGI:MGI:3628833\|PMID:16601693
Biological Process	GO:0046330	positive regulation of JNK cascade	Axin1	IMP		Mouse	MGI:MGI:3799599\|PMID:17681137
Biological Process	GO:0046330	positive regulation of JNK cascade	Axin1	IMP	MGI:MGI:1856035	Mouse	PMID:18316368
Biological Process	GO:0046330	positive regulation of JNK cascade	axin1	IMP		Zfish	PMID:17681137\|ZFIN:ZDB-PUB-070813-12
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Axin1	IMP		Mouse	PMID:15579909
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Axin1	IDA		Mouse	PMID:12878610
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Axin1	IMP		Mouse	PMID:12878610
Biological Process	GO:0043507	positive regulation of JUN kinase activity	axin1	IDA		Zfish	PMID:17681137\|ZFIN:ZDB-PUB-070813-12
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Axin1	IDA		Mouse	MGI:MGI:5705228\|PMID:11955436
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Axin1	IDA		Mouse	MGI:MGI:5705228\|PMID:11955436
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Axin1	IDA		Mouse	PMID:16601693
Biological Process	GO:0045732	positive regulation of protein catabolic process	AXIN1	IDA		Human	PMID:9601641
Biological Process	GO:0045860	positive regulation of protein kinase activity	Axin1	IDA		Mouse	MGI:MGI:3521522\|PMID:15526030
Biological Process	GO:0045860	positive regulation of protein kinase activity	Axin1	IDA		Rat	PMID:15228590\|RGD:1304344
Biological Process	GO:0001934	positive regulation of protein phosphorylation	AXIN1	IDA		Human	PMID:9601641
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Axin1	IDA		Mouse	PMID:10330403
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Axin1	IGI	MGI:MGI:1934919	Mouse	PMID:16601693
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Axin1	IDA		Mouse	PMID:16601693
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Axin1	IMP		Mouse	PMID:16601693
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Axin1	IMP		Mouse	PMID:16601693
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Axin1	IGI	MGI:MGI:1934919	Mouse	PMID:16601693
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Axin1	IDA		Mouse	PMID:16601693
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Axin1	IDA		Mouse	PMID:16601693
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Axin1	IDA		Rat	PMID:10228155\|RGD:8553327
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	AXIN1	IMP		Human	PMID:16601693
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	Axin1	IMP		Mouse	MGI:MGI:3628833\|PMID:16601693
Biological Process	GO:0036342	post-anal tail morphogenesis	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0036342	post-anal tail morphogenesis	Axin1	IMP	MGI:MGI:1856036	Mouse	MGI:MGI:48782
Biological Process	GO:0036342	post-anal tail morphogenesis	Axin1	IMP	MGI:MGI:1856035	Mouse	PMID:12601169
Biological Process	GO:0030163	protein catabolic process	Axin1	IDA		Mouse	PMID:12717450
Biological Process	GO:0000209	protein polyubiquitination	Axin1	IDA		Mouse	PMID:16601693
Biological Process	GO:0065003	protein-containing complex assembly	AXIN1	IDA		Human	PMID:16601693
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Axin1	IDA		Mouse	PMID:14981260
Biological Process	GO:0046328	regulation of JNK cascade	axin1	IDA		Zfish	PMID:17681137
Biological Process	GO:0001932	regulation of protein phosphorylation	Axin1	IGI	MGI:MGI:94941	Mouse	PMID:14734535
Biological Process	GO:1905235	response to quercetin	Axin1	IEP		Rat	PMID:28032729\|RGD:150530464
Biological Process	GO:0007605	sensory perception of sound	Axin1	IMP	MGI:MGI:1856035	Mouse	PMID:21003499
Biological Process	GO:0007605	sensory perception of sound	Axin1	IMP	MGI:MGI:1856035	Mouse	MGI:MGI:48782
Biological Process	GO:0001756	somitogenesis	axin1	IGI	ZFIN:ZDB-GENO-100719-1	Zfish	PMID:19517013
Biological Process	GO:0016055	Wnt signaling pathway	Axin1	IPI	PR:P51141	Mouse	PMID:11113207
Biological Process	GO:0016055	Wnt signaling pathway	Axin1	IDA		Mouse	PMID:11113207
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	axin1	IGI	ZFIN:ZDB-GENO-100719-1	Zfish	PMID:19517013

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.