| GO term: | beta-catenin destruction complex |
| Synonym: | 23S APC complex |
| Synonym: | APC-Axin-1-beta-catenin complex |
| Synonym: | Axin-APC-beta-catenin-GSK3B complex |
| Synonym: | beta-catenin degradation complex |
| GO id: | GO:0030877 |
| Definition: | A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. |
| Comments | Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. |
| Number of paths to term: | 9 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship