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Axin1
Gene Detail
 Symbol
Name
ID
Axin1
axin 1
MGI:1096327
Feature Type protein coding gene
Genetic Map
Chromosome 17
13.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr17:26138688-26195811 bp, + strand
From VEGA annotation of GRCm38

  57124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: axis inhibition protein (axin)
Gene Tree: Axin1

Human
homologs
Human Homolog AXIN1, axin 1
NCBI Gene ID 8312
neXtProt AC  NX_O15169
Human Synonyms  AXIN, PPP1R49
Human Chr (Location)  16p13.3; chr16:287440-355241 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human AXIN1
Alleles
and
phenotypes
All alleles(23) : Targeted(12) Gene trapped(7) Transgenic(1) Spontaneous(3)
 
Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.
 
Gene Ontology
(GO)
classifications
All GO classifications: (151 annotations)
Process activation of JUN kinase activity, activation of protein kinase activity, ...
Component beta-catenin destruction complex, cell cortex, ...
Function armadillo repeat domain binding, beta-catenin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (96)    Tissues (70)    Images (14)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 70
Northern blot 10
Western blot 16
cDNA source data(107)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(111) cDNA(110) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026498 (Evidence)
Ensembl Gene ModelENSMUSG00000024182 (Evidence)
Entrez Gene12005 (Evidence)
UniGene23684
DFCITC1597217, TC1601650
DoTSDT.532261, DT.94403039
NIA Mouse Gene IndexU017701
PDB3UTM
Consensus CDS ProjectCCDS28547.2, CCDS50042.1
International Mouse Knockout Project StatusAxin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026498 VEGA Gene Model | MGI Sequence Detail 57124 C57BL/6J ±  kb
transcript OTTMUST00000065524 VEGA | MGI Sequence Detail 3777 Not Applicable 
polypeptide OTTMUSP00000032667 VEGA | MGI Sequence Detail 868 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014936 Axin beta-catenin binding
InterPro IPR001158 DIX domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000004526 axin-1
References (Earliest) J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
(Latest) J:205915 Zhang YL, et al., AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab. 2013 Oct 1;18(4):546-55
All references(133)
Other
accession IDs
MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory