About   Help   FAQ
Axin1
Gene Detail
Symbol

Name
ID
Axin1
axin 1
MGI:1096327
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr17:26138688-26195811 bp, + strand
From VEGA annotation of GRCm38

  57124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: axis inhibition protein (axin)
Gene Tree: Axin1

Human
homologs
Human Homolog AXIN1, axin 1
NCBI Gene ID 8312
neXtProt AC  NX_O15169
Human Synonyms  AXIN, PPP1R49
Human Chr (Location)  16p13.3; chr16:287440-355241 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human AXIN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(7) Radiation induced(2) Spontaneous(3) Targeted(12) Transgenic(1)
Genomic Mutations involving Axin1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.
 
Interactions
Axin1 interacts with 154 markers (Mir18, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (21 records)
Data Summary: Results (96)    Tissues (71)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
Northern blot 10
Western blot 16
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) cDNA(110) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026498 (Evidence)
Ensembl Gene ModelENSMUSG00000024182 (Evidence)
Entrez Gene12005 (Evidence)
UniGene23684
DFCITC1601650, TC1597217
DoTSDT.532261, DT.94403039
NIA Mouse Gene IndexU017701
PDB3UTM
Consensus CDS ProjectCCDS28547.2, CCDS50042.1
International Mouse Knockout Project StatusAxin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026498 VEGA Gene Model | MGI Sequence Detail 57124 C57BL/6J ±  kb
transcript OTTMUST00000065524 VEGA | MGI Sequence Detail 3777 Not Applicable 
polypeptide OTTMUSP00000032667 VEGA | MGI Sequence Detail 868 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(8) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014936 Axin beta-catenin binding
InterPro IPR001158 DIX domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000004526 axin-1
References
(Earliest) J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
(Latest) J:213869 Caronia-Brown G, et al., The cortical hem regulates the size and patterning of neocortex. Development. 2014 Jul;141(14):2855-65
All references(138)
Other
accession IDs
MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory