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Axin1 Gene Detail
Summary
  • Symbol
    Axin1
  • Name
    axin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096327
    NCBI Gene: 12005
Location & Maps
more
  • Sequence Map
    Chr17:26138688-26195811 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57124 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AXIN1, axin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AXIN1, axin 1
    Orthology source: HomoloGene
  • Synonyms
    AXIN, PPP1R49
  • Links
    NCBI Gene ID: 8312
    neXtProt AC: NX_O15169

  • Chr Location
    16p13.3; chr16:287440-361497 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human AXIN1 associations

Human Disease Mouse Models
       Caudal Duplication Anomaly   OMIM: 607864
Hepatocellular Carcinoma   OMIM: 114550
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 9 alleles in 15 genetic backgrounds
    7 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    7
  • Radiation induced
    2
  • Spontaneous
    3
  • Targeted
    13
  • Transgenic
    1
  • Genomic Mutations
    2 involving Axin1
  • Incidental Mutations
Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026498 VEGA Gene Model | MGI Sequence Detail 57124 C57BL/6J ±  kb
transcript OTTMUST00000065524 VEGA | MGI Sequence Detail 3777 Not Applicable  
polypeptide OTTMUSP00000032667 VEGA | MGI Sequence Detail 868 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    195 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 111
    cDNA 110
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592
References
more
  • Summaries
    All 137
    Developmental Gene Expression 21
    Gene Ontology 48
    Phenotypes 41
  • Earliest
    J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
  • Latest
    J:220301 Zhang MZ, et al., TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis. Cancer Cell. 2015 Apr 13;27(4):547-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory