Axin1
Gene Detail

Symbol Name ID

Axin1 axin 1 MGI:1096327

Feature Type

protein coding gene

Genetic Map

Chromosome 17

13.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr17:26138688-26195811 bp, + strand From VEGA annotation of GRCm38   57124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: axis inhibition protein (axin)
Gene Tree: Axin1

Human homologs

Human Homolog		AXIN1, axin 1
NCBI Gene ID		8312
neXtProt AC		NX_O15169
Human Synonyms		AXIN, PPP1R49
Human Chr (Location)		16p13.3; chr16:337440-402676 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human AXIN1

Alleles and phenotypes

All alleles(23) : Targeted(12) Gene trapped(7) Transgenic(1) Spontaneous(3)
 

Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (149 annotations)

Process	activation of JUN kinase activity, activation of protein kinase activity, ...
Component	beta-catenin destruction complex, cell cortex, ...
Function	armadillo repeat domain binding, beta-catenin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (96)    Tissues (70)    Images (14)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	70
Northern blot	10
Western blot	16

cDNA source data(107)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(111) cDNA(110) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026498 (Evidence)
Ensembl Gene Model	ENSMUSG00000024182 (Evidence)
Entrez Gene	12005 (Evidence)
UniGene	23684
DFCI	TC1597217, TC1601650
DoTS	DT.532261, DT.94403039
NIA Mouse Gene Index	U017701
PDB	3UTM
Consensus CDS Project	CCDS28547.2, CCDS50042.1
International Mouse Knockout Project Status	Axin1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026498	VEGA Gene Model | MGI Sequence Detail	57124	C57BL/6J
transcript	OTTMUST00000065524	VEGA | MGI Sequence Detail	3777	Not Applicable
polypeptide	OTTMUSP00000032667	VEGA | MGI Sequence Detail	868	Not Applicable

All sequences(48) RefSeq(4) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014936	Axin beta-catenin binding
InterPro	IPR001158	DIX domain
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000004526	axin-1

References

(Earliest) J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(130)

Other accession IDs

MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592