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Axin1
Gene Detail
Symbol

Name
ID
Axin1
axin 1
MGI:1096327
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr17:26138688-26195811 bp, + strand
From VEGA annotation of GRCm38

  57124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AXIN1
Protein SuperFamily: axis inhibition protein (axin)
Gene Tree: Axin1

Human
homologs
AXIN1, axin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8312
neXtProt AC: NX_O15169

Human Synonyms: AXIN, PPP1R49

Human Chr (Location): 16p13.3; chr16:287440-361497 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human AXIN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(7) Radiation induced(2) Spontaneous(3) Targeted(12) Transgenic(1)
Genomic Mutations involving Axin1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.
 
Interactions
Axin1 interacts with 153 markers (Mir18, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (21 records)
Data Summary: Results (96)    Tissues (71)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
Northern blot 10
Western blot 16
cDNA source data(107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AXIN1 ; Xenbase axin1 ; ZFIN axin1    NEW 
Molecular
reagents
All nucleic(111) cDNA(110) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026498 (Evidence)
Ensembl Gene Model ENSMUSG00000024182 (Evidence)
Entrez Gene 12005 (Evidence)
UniGene 23684
DFCI TC1597217, TC1601650
DoTS DT.532261, DT.94403039
NIA Mouse Gene Index U017701
PDB 3UTM
Consensus CDS Project CCDS28547.2, CCDS50042.1
International Mouse Phenotyping Consortium Status Axin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026498 VEGA Gene Model | MGI Sequence Detail 57124 C57BL/6J ±  kb
transcript OTTMUST00000065524 VEGA | MGI Sequence Detail 3777 Not Applicable 
polypeptide OTTMUSP00000032667 VEGA | MGI Sequence Detail 868 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029797 Axin-1
InterPro IPR014936 Axin beta-catenin binding
InterPro IPR001158 DIX domain
InterPro IPR016137 RGS domain
InterPro IPR024066 RGS, subdomain 1
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000004526 axin-1
References
(Earliest) J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
(Latest) J:214515 Azzolin L, et al., YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell. 2014 Jul 3;158(1):157-70
All references(137)
Other
accession IDs
MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory