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Term Detail
GO term:nucleocytoplasmic transport
Synonym: nucleocytoplasmic shuttling
GO id:GO:0006913
Definition:The directed movement of molecules between the nucleus and the cytoplasm.
CommentsNote that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-acellular localization
                                part-ofestablishment of localization in cell
                                        is-aintracellular transport
                                                is-acytoplasmic transport
                                                        is-acalcium ion import into cytosol +
                                                        is-acalcium ion import into sarcoplasmic reticulum +
                                                        is-acalcium ion transport into cytosol +
                                                        is-acytoplasmic transport, nurse cell to oocyte +
                                                        is-acytosol to ER transport
                                                        is-aearly endosome to Golgi transport
                                                        is-aearly endosome to late endosome transport +
                                                        is-aearly endosome to recycling endosome transport +
                                                        is-aendoplasmic reticulum to chloroplast transport +
                                                        is-aendosome to lysosome transport +
                                                        is-aendosome to pigment granule transport +
                                                        is-aER to Golgi vesicle-mediated transport +
                                                        is-afructose export from vacuole to cytoplasm
                                                        is-aGDP-fucose import into endoplasmic reticulum lumen
                                                        is-aGDP-fucose import into Golgi lumen
                                                        is-aGolgi to endosome transport +
                                                        is-aGolgi to plasma membrane transport +
                                                        is-aGolgi to secretory granule transport
                                                        is-aGolgi to transport vesicle transport
                                                        is-aGolgi to vacuole transport +
                                                        is-alate endosome to Golgi transport
                                                        is-alate endosome to vacuole transport +
                                                        is-alysosome to ER cholesterol transport
                                                        is-amitochondrial rRNA export from mitochondrion +
                                                        is-anucleocytoplasmic transport [GO:0006913] (319 genes, 424 annotations)
                                                                negatively-regulatesnegative regulation of nucleocytoplasmic transport +
                                                                is-anuclear export +
                                                                is-anuclear import +
                                                                positively-regulatespositive regulation of nuclear envelope permeability
                                                                positively-regulatespositive regulation of nucleocytoplasmic transport +
                                                                regulatesregulation of nucleocytoplasmic transport +
                                                        is-aoligopeptide export from mitochondrion
                                                        is-aplasma membrane to endosome transport
                                                        is-aprotein exit from endoplasmic reticulum +
                                                        is-aprotein import into mitochondrial inner membrane
                                                        is-aprotein import into mitochondrial intermembrane space
                                                        is-aprotein import into mitochondrial matrix
                                                        is-aprotein import into mitochondrial outer membrane
                                                        is-aprotein targeting to chloroplast +
                                                        is-aprotein targeting to ER +
                                                        is-aprotein targeting to Golgi
                                                        is-aprotein targeting to mitochondrion +
                                                        is-aprotein targeting to peroxisome +
                                                        is-aprotein targeting to vacuole +
                                                        is-arecycling endosome to Golgi transport
                                                        is-aRNA import into mitochondrion +
                                                        is-atrans-Golgi network to recycling endosome transport
                                                        is-aUDP-galactose transmembrane import into Golgi lumen
                                                        is-avacuolar transmembrane transport +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-acellular localization
                                part-ofestablishment of localization in cell
                                        is-aintracellular transport
                                                is-anuclear transport
                                                        is-amicrotubule-dependent intracellular transport of viral material towards nucleus
                                                        is-anucleocytoplasmic transport [GO:0006913] (319 genes, 424 annotations)
                                                                negatively-regulatesnegative regulation of nucleocytoplasmic transport +
                                                                is-anuclear export +
                                                                is-anuclear import +
                                                                positively-regulatespositive regulation of nuclear envelope permeability
                                                                positively-regulatespositive regulation of nucleocytoplasmic transport +
                                                                regulatesregulation of nucleocytoplasmic transport +
                                                        is-anucleolus to nucleoplasm transport
                                                        is-aprotein targeting to nuclear inner membrane
                                                        is-aprotein targeting to nucleus +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-aestablishment of localization in cell
                                        is-aintracellular transport
                                                is-acytoplasmic transport
                                                        is-acalcium ion import into cytosol +
                                                        is-acalcium ion import into sarcoplasmic reticulum +
                                                        is-acalcium ion transport into cytosol +
                                                        is-acytoplasmic transport, nurse cell to oocyte +
                                                        is-acytosol to ER transport
                                                        is-aearly endosome to Golgi transport
                                                        is-aearly endosome to late endosome transport +
                                                        is-aearly endosome to recycling endosome transport +
                                                        is-aendoplasmic reticulum to chloroplast transport +
                                                        is-aendosome to lysosome transport +
                                                        is-aendosome to pigment granule transport +
                                                        is-aER to Golgi vesicle-mediated transport +
                                                        is-afructose export from vacuole to cytoplasm
                                                        is-aGDP-fucose import into endoplasmic reticulum lumen
                                                        is-aGDP-fucose import into Golgi lumen
                                                        is-aGolgi to endosome transport +
                                                        is-aGolgi to plasma membrane transport +
                                                        is-aGolgi to secretory granule transport
                                                        is-aGolgi to transport vesicle transport
                                                        is-aGolgi to vacuole transport +
                                                        is-alate endosome to Golgi transport
                                                        is-alate endosome to vacuole transport +
                                                        is-alysosome to ER cholesterol transport
                                                        is-amitochondrial rRNA export from mitochondrion +
                                                        is-anucleocytoplasmic transport [GO:0006913] (319 genes, 424 annotations)
                                                                negatively-regulatesnegative regulation of nucleocytoplasmic transport +
                                                                is-anuclear export +
                                                                is-anuclear import +
                                                                positively-regulatespositive regulation of nuclear envelope permeability
                                                                positively-regulatespositive regulation of nucleocytoplasmic transport +
                                                                regulatesregulation of nucleocytoplasmic transport +
                                                        is-aoligopeptide export from mitochondrion
                                                        is-aplasma membrane to endosome transport
                                                        is-aprotein exit from endoplasmic reticulum +
                                                        is-aprotein import into mitochondrial inner membrane
                                                        is-aprotein import into mitochondrial intermembrane space
                                                        is-aprotein import into mitochondrial matrix
                                                        is-aprotein import into mitochondrial outer membrane
                                                        is-aprotein targeting to chloroplast +
                                                        is-aprotein targeting to ER +
                                                        is-aprotein targeting to Golgi
                                                        is-aprotein targeting to mitochondrion +
                                                        is-aprotein targeting to peroxisome +
                                                        is-aprotein targeting to vacuole +
                                                        is-arecycling endosome to Golgi transport
                                                        is-aRNA import into mitochondrion +
                                                        is-atrans-Golgi network to recycling endosome transport
                                                        is-aUDP-galactose transmembrane import into Golgi lumen
                                                        is-avacuolar transmembrane transport +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-aestablishment of localization in cell
                                        is-aintracellular transport
                                                is-anuclear transport
                                                        is-amicrotubule-dependent intracellular transport of viral material towards nucleus
                                                        is-anucleocytoplasmic transport [GO:0006913] (319 genes, 424 annotations)
                                                                negatively-regulatesnegative regulation of nucleocytoplasmic transport +
                                                                is-anuclear export +
                                                                is-anuclear import +
                                                                positively-regulatespositive regulation of nuclear envelope permeability
                                                                positively-regulatespositive regulation of nucleocytoplasmic transport +
                                                                regulatesregulation of nucleocytoplasmic transport +
                                                        is-anucleolus to nucleoplasm transport
                                                        is-aprotein targeting to nuclear inner membrane
                                                        is-aprotein targeting to nucleus +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-aintracellular transport
                                                is-acytoplasmic transport
                                                        is-acalcium ion import into cytosol +
                                                        is-acalcium ion import into sarcoplasmic reticulum +
                                                        is-acalcium ion transport into cytosol +
                                                        is-acytoplasmic transport, nurse cell to oocyte +
                                                        is-acytosol to ER transport
                                                        is-aearly endosome to Golgi transport
                                                        is-aearly endosome to late endosome transport +
                                                        is-aearly endosome to recycling endosome transport +
                                                        is-aendoplasmic reticulum to chloroplast transport +
                                                        is-aendosome to lysosome transport +
                                                        is-aendosome to pigment granule transport +
                                                        is-aER to Golgi vesicle-mediated transport +
                                                        is-afructose export from vacuole to cytoplasm
                                                        is-aGDP-fucose import into endoplasmic reticulum lumen
                                                        is-aGDP-fucose import into Golgi lumen
                                                        is-aGolgi to endosome transport +
                                                        is-aGolgi to plasma membrane transport +
                                                        is-aGolgi to secretory granule transport
                                                        is-aGolgi to transport vesicle transport
                                                        is-aGolgi to vacuole transport +
                                                        is-alate endosome to Golgi transport
                                                        is-alate endosome to vacuole transport +
                                                        is-alysosome to ER cholesterol transport
                                                        is-amitochondrial rRNA export from mitochondrion +
                                                        is-anucleocytoplasmic transport [GO:0006913] (319 genes, 424 annotations)
                                                                negatively-regulatesnegative regulation of nucleocytoplasmic transport +
                                                                is-anuclear export +
                                                                is-anuclear import +
                                                                positively-regulatespositive regulation of nuclear envelope permeability
                                                                positively-regulatespositive regulation of nucleocytoplasmic transport +
                                                                regulatesregulation of nucleocytoplasmic transport +
                                                        is-aoligopeptide export from mitochondrion
                                                        is-aplasma membrane to endosome transport
                                                        is-aprotein exit from endoplasmic reticulum +
                                                        is-aprotein import into mitochondrial inner membrane
                                                        is-aprotein import into mitochondrial intermembrane space
                                                        is-aprotein import into mitochondrial matrix
                                                        is-aprotein import into mitochondrial outer membrane
                                                        is-aprotein targeting to chloroplast +
                                                        is-aprotein targeting to ER +
                                                        is-aprotein targeting to Golgi
                                                        is-aprotein targeting to mitochondrion +
                                                        is-aprotein targeting to peroxisome +
                                                        is-aprotein targeting to vacuole +
                                                        is-arecycling endosome to Golgi transport
                                                        is-aRNA import into mitochondrion +
                                                        is-atrans-Golgi network to recycling endosome transport
                                                        is-aUDP-galactose transmembrane import into Golgi lumen
                                                        is-avacuolar transmembrane transport +


Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-aintracellular transport
                                                is-anuclear transport
                                                        is-amicrotubule-dependent intracellular transport of viral material towards nucleus
                                                        is-anucleocytoplasmic transport [GO:0006913] (319 genes, 424 annotations)
                                                                negatively-regulatesnegative regulation of nucleocytoplasmic transport +
                                                                is-anuclear export +
                                                                is-anuclear import +
                                                                positively-regulatespositive regulation of nuclear envelope permeability
                                                                positively-regulatespositive regulation of nucleocytoplasmic transport +
                                                                regulatesregulation of nucleocytoplasmic transport +
                                                        is-anucleolus to nucleoplasm transport
                                                        is-aprotein targeting to nuclear inner membrane
                                                        is-aprotein targeting to nucleus +


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory