Sjogren's syndrome Disease Ontology Browser

Disease Ontology Browser

Sjogren's syndrome (DOID:12894)
Alliance: disease page
Synonyms: Sicca syndrome; Sjogren syndrome; xerodermosteosis
Alt IDs: OMIM:270150, DOID:416, ICD10CM:M35.0, ICD9CM:710.2, MESH:D012859, NCI:C26883, NCI:C70647, UMLS_CUI:C0086981, UMLS_CUI:C1527336
Definition: An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.

Term Browser
Genes (38)
Models (31)

Disease References using Mouse Models (51)

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Aire

Allelic Composition	Genetic Background	Reference	Phenotypes
Airetm1Mmat/Airetm1Mmat	involves: C57BL/6 * CBA	J:96580	View
Airetm1.1Doi/Airetm1.1Doi Il1r1tm1Imx/Il1r1tm1Imx	involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	J:163691	View
Airetm1.1Doi/Airetm1.1Doi Il1r1tm1Imx/Il1r1+	involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	J:163691	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Ccr7

Allelic Composition	Genetic Background	Reference	Phenotypes
Ccr7tm1Rfor/Ccr7tm1Rfor	B6.129P2-Ccr7^tm1Rfor	J:110910	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Cyp19a1

Allelic Composition	Genetic Background	Reference	Phenotypes
Cyp19a1tm1Sih/Cyp19a1tm1Sih	involves: 129S/SvEv	J:216958	View
Cyp19a1tm1Esi/Cyp19a1tm1Esi	involves: 129S6/SvEvTac * C57BL/6	J:92438	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: E2f1

Allelic Composition	Genetic Background	Reference	Phenotypes
E2f1tm1Meg/E2f1tm1Meg	NOD.Cg-E2f1^tm1Meg	J:93708	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Fas

Allelic Composition	Genetic Background	Reference	Phenotypes
Faslpr/Faslpr Tnfrsf9tm1Byk/Tnfrsf9tm1Byk	MRL.Cg-Tnfrsf9^tm1Byk Fas^lpr	J:120559	View
Faslpr/Faslpr	C3.MRL-Fas^lpr	J:1028	View
Faslpr/Faslpr	MRL/Mp-Fas^lpr	J:1028, J:18512, J:21965	View
Faslpr/Faslpr	MRL/MpJ-Fas^lpr/J	J:123192	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Id3

Allelic Composition	Genetic Background	Reference	Phenotypes
Id3tm1Zhu/Id3tm1Zhu	involves: 129S4/SvJaeSor	J:93916	View
Id3tm2.1Zhu/Id3tm2.1Zhu Tg(Lck-cre)#Zhu/0	involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J	J:172701	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Il2

Allelic Composition	Genetic Background	Reference	Phenotypes
Il2tm1Hor/Il2tm1Hor	B6.129P2-Il2^tm1Hor/J	J:125129	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Il2ra

Allelic Composition	Genetic Background	Reference	Phenotypes
Il2ratm1Dw/Il2ratm1Dw	B6.129S4-Il2ra^tm1Dw/J	J:125129	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Il4

Allelic Composition	Genetic Background	Reference	Phenotypes
Il4tm1Cgn/Il4tm1Cgn	NOD.129P2-Il4^tm1Cgn	J:105803	View
Il4tm1Cgn/Il4tm1Cgn	NOD.Cg-H2^b Il4^tm1Cgn	J:105803	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Map3k14

Allelic Composition	Genetic Background	Reference	Phenotypes
Map3k14aly/Map3k14aly	involves: C57BL/6J	J:38580	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Muc19

Allelic Composition	Genetic Background	Reference	Phenotypes
Muc19sld/Muc19sld	NFS/N-Muc19^sld	J:20364, J:62145, J:106272, J:216958	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Nfkbia

Allelic Composition	Genetic Background	Reference	Phenotypes
Nfkbiatm1.1Pjc/Nfkbiatm1.1Pjc	involves: C57BL/6	J:163686	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: plt

Allelic Composition	Genetic Background	Reference	Phenotypes
plt/plt	either: B6.DDD-plt or C.DDD-plt	J:110910	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Rorc

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CD2-Rorc)#Staka/0	involves: C57BL/6	J:230700	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Satb1

Allelic Composition	Genetic Background	Reference	Phenotypes
Satb1tm2Kos/Satb1tm2Kos Commd10Tg(Vav1-icre)A2Kio/Commd10+	involves: C57BL/6 * C57BL/10 * CBA/Ca	J:252606	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: St14

Allelic Composition	Genetic Background	Reference	Phenotypes
St14tm2Bug/St14tm3Bug Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss	J:213072	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Tgfb1

Allelic Composition	Genetic Background	Reference	Phenotypes
Tgfb1tm1Doe/Tgfb1tm1Doe	involves: 129S2/SvPas * CF-1	J:2892	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Thbs1

Allelic Composition	Genetic Background	Reference	Phenotypes
Thbs1tm1Hyn/Thbs1tm1Hyn	involves: 129S2/SvPas * C57BL/6	J:153126	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Tnfsf13b

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Tnfsf13b)1Fma/0	B6.Cg-Tg(Tnfsf13b)1Fma	J:73711	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Gene: Traf3ip2

Allelic Composition	Genetic Background	Reference	Phenotypes
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix	C.129-Traf3ip2^tm1.1Lix	J:138560	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Transgene: Tg(CD2-Rorc)#Staka

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CD2-Rorc)#Staka/0	involves: C57BL/6	J:230700	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Transgene: Tg(Emu-TXLNA)1Amjr

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Emu-TXLNA)1Amjr/0	B6.Cg-Tg(Emu-TXLNA)1Amjr	J:145185	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Transgene: Tg(Psp-Rbbp4)1Yoha

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Psp-Rbbp4)1Yoha/0	involves: C57BL/6	J:141378	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome
Associated Mouse Transgene: Tg(Tnfsf13b)1Fma

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Tnfsf13b)1Fma/0	B6.Cg-Tg(Tnfsf13b)1Fma	J:73711	View

Mouse Models

Human Disease Modeled: Sjogren's syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Aec1NOD/Uf/Aec1NOD/Uf Aec2NOD/Uf/Aec2NOD/Uf	B6.NOD-Aec2^NOD/Uf Aec1^NOD/Uf	J:128900, J:129916, J:129282	View

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