Analysis Tools
hematopoietic system
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• IgM dull subset of B cells is larger in transgenic mice compared to control
• B220hi/IgMhi B cell subset is greatly increased in transgenic mice
• large IgMhi B cell subset is phenotypically different from the small IgMhi B cell subset in controls, resembling marginal zone B cells
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• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice
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• presence of B-1a (CD5+) B cells are detected compared to controls
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• a 3-fold increase in B-1b (CD5-) B cells
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• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations (mutants 45.5% vs wild-type 14.4%)
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• numerous germinal centers are observed in B cell follicles of young transgenic mice compared to wild-type and aged transgenic mice
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• splenic marginal zone is increased in size, particularly notable in aged mice
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• mice exhibit elevated levels in both steady state and in response to antigen stimulation; at 12 weeks of age, IgA levels are increased 1500-fold over wild-type (22.7 mg/ml IgA vs 0.015 mg/ml in wild-type - hyper-IgA)
• augmented IgA staining is found in lamina propria of transgenic mice
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immune system
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• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates
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• IgM dull subset of B cells is larger in transgenic mice compared to control
• B220hi/IgMhi B cell subset is greatly increased in transgenic mice
• large IgMhi B cell subset is phenotypically different from the small IgMhi B cell subset in controls, resembling marginal zone B cells
|
|
• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice
|
|
• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations (mutants 45.5% vs wild-type 14.4%)
|
|
• presence of B-1a (CD5+) B cells are detected compared to controls
|
|
• a 3-fold increase in B-1b (CD5-) B cells
|
|
• numerous germinal centers are observed in B cell follicles of young transgenic mice compared to wild-type and aged transgenic mice
|
|
• splenic marginal zone is increased in size, particularly notable in aged mice
|
|
• mice exhibit elevated levels in both steady state and in response to antigen stimulation; at 12 weeks of age, IgA levels are increased 1500-fold over wild-type (22.7 mg/ml IgA vs 0.015 mg/ml in wild-type - hyper-IgA)
• augmented IgA staining is found in lamina propria of transgenic mice
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• most mice over 13 months of age show signs of severe nephritis
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renal/urinary system
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• proteinuria is detected only in a subset of 8-month old mice
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• most mice over 13 months of age show signs of severe nephritis
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• IgA immune complexes are detected in majority of young and aged mice
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• significant IgA deposits are found specifically in kidney glomerular mesangium
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• IgA deposits are found in nearly all glomeruli, while deposits of each IgG, and IgM are also detected, while very little Ig deposition is found in wild-type kidneys
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• in 8-month old mice, glomeruli are slightly enlarged and hypercellular
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homeostasis/metabolism
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• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months
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• proteinuria is detected only in a subset of 8-month old mice
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digestive/alimentary system
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• many mice over 13 months of age have enlarged salivary glands
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• some mice (3 cases) have large submaxillary tumors which contain hyperplastic lymphoid tissue composed of activated B cells and numerous germinal centers; these abnormal aggregates of B lymphoid cells are found in lymphocytic infiltrates of some tumor-free mice
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• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months
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• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates
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endocrine/exocrine glands
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• many mice over 13 months of age have enlarged salivary glands
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• some mice (3 cases) have large submaxillary tumors which contain hyperplastic lymphoid tissue composed of activated B cells and numerous germinal centers; these abnormal aggregates of B lymphoid cells are found in lymphocytic infiltrates of some tumor-free mice
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• mice aged 12-15.5 months of age produce significantly less saliva compared to age-matched controls; this difference is not observed in mice aged 8-10 months
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• 60% of mice over 12 months of age have severely inflamed salivary glands with large leukocytic infiltrates
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neoplasm
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• some mice (3 cases) have large submaxillary tumors which contain hyperplastic lymphoid tissue composed of activated B cells and numerous germinal centers; these abnormal aggregates of B lymphoid cells are found in lymphocytic infiltrates of some tumor-free mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Sjogren's syndrome | DOID:12894 |
OMIM:270150 |
J:73711 | |
