Thbs1^tm1Hyn
Targeted Allele Detail

Summary

• Symbol: Thbs1^tm1Hyn
• Name: thrombospondin 1; targeted mutation 1, Richard Hynes
• MGI ID: MGI:2154534
• Synonyms: tbsp1-, Thbs1^-, TSP-1, TSP-1^-, TSP1-, Tsp-1KO
• Gene: Thbs1 Location: Chr2:117942357-117957614 bp, + strand Genetic Position: Chr2, 59.34 cM, cytoband F1-F3
• Alliance: Thbs1^tm1Hyn page

Lordotic curvature of the spine in Thbs1^tm1Hyn/Thbs1^tm1Hyn mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46182
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 2, intron 3, and exon 3. An RNase protection assay demonstrated that no detectable transcript was present in multiple tissues of homozygous animals. Western analysis confirmed the absence of the encoded protein. (J:46182)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Thbs1^tm1Hyn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Thbs1 Mutation: 69 strains or lines available

References

• Original: J:46182 Lawler J, et al., Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998 Mar 1;101(5):982-92
• All: 153 reference(s)