Analysis Tools
endocrine/exocrine glands
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• mice exhibit sialadenitis unlike wild-type mice
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• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice
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• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
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• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
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• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
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• mice exhibit dacryoadenitis unlike wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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immune system
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• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
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• mice exhibit autoimmune exocrinopathy unlike wild-type mice
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• mice exhibit sialadenitis unlike wild-type mice
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• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice
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homeostasis/metabolism
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• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
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digestive/alimentary system
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• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
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• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
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• mice exhibit sialadenitis unlike wild-type mice
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• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
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vision/eye
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• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
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• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice
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cellular
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• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
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hematopoietic system
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• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Sjogren's syndrome | DOID:12894 |
OMIM:270150 |
J:110910 | |
