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Rorc Gene Detail
Summary
  • Symbol
    Rorc
  • Name
    RAR-related orphan receptor gamma
  • Synonyms
    RORgamma, Thor, thymus orphan receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:104856
    NCBI Gene: 19885
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
  • Regulated by
    Rr306, Rr307 (2 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr3:94280106-94305583 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.56 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    949 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104856
 protein coding gene Chr3:94280101-94305583 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027547
 protein coding gene Chr3:94944849-94971754 (+)
A/J MGP_AJ_G0027506
 protein coding gene Chr3:92054987-92081780 (+)
AKR/J MGP_AKRJ_G0027474
 protein coding gene Chr3:94144808-94172361 (+)
BALB/cJ MGP_BALBcJ_G0027517
 protein coding gene Chr3:91758692-91784334 (+)
C3H/HeJ MGP_C3HHeJ_G0027253
 protein coding gene Chr3:94436694-94463209 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027966
 protein coding gene Chr3:98536689-98562421 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025308
 protein coding gene Chr3:88544731-88572028 (+)
CAST/EiJ MGP_CASTEiJ_G0026701
 protein coding gene Chr3:93786277-93813753 (+)
CBA/J MGP_CBAJ_G0027229
 protein coding gene Chr3:102027321-102053054 (+)
DBA/2J MGP_DBA2J_G0027368
 protein coding gene Chr3:91315859-91341543 (+)
FVB/NJ MGP_FVBNJ_G0027338
 protein coding gene Chr3:89419831-89446065 (+)
LP/J MGP_LPJ_G0027476
 protein coding gene Chr3:96254444-96280194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027365
 protein coding gene Chr3:108261034-108286611 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028020
 protein coding gene Chr3:93827495-93854509 (+)
PWK/PhJ MGP_PWKPhJ_G0026429
 protein coding gene Chr3:91207039-91233423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026250
 protein coding gene Chr3:92168142-92193965 (+)
WSB/EiJ MGP_WSBEiJ_G0026784
 protein coding gene Chr3:94176828-94202468 (+)



Homology
more
  • Human Ortholog
    RORC, RAR related orphan receptor C
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RORC, RAR related orphan receptor C
  • Synonyms
    IMD42, NR1F3, RORG, RZRG, RZR-GAMMA, TOR
  • Links
    NCBI Gene ID: 6097
    UniProt: P51449

  • Chr Location
    1q21.3; chr1:151806071-151831845 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rorc mouse models; 1 with human RORC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 8 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    330 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit lack of peripheral and mesenteric lymph nodes and Peyer's patches, reduced numbers of thymocytes, and increased apoptosis with loss of thymic expression of anti-apoptosic factor Bcl-xL.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    89
  • cDNA Data
    36
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19885 NCBI Gene Model | MGI Sequence Detail 25478 C57BL/6J ±  kb
    transcript NR_121656 RefSeq | MGI Sequence Detail 3250 C57BL/6  
    polypeptide P51450 UniProt | EBI | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 2
      cDNA 40
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28153
    References
    more
    • Summaries
      All 434
      Developmental Gene Expression 21
      Diseases 2
      Gene Ontology 10
      Phenotypes 330
    • Earliest
      J:30013 Ortiz MA, et al., TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol. 1995 Dec;9(12):1679-91
    • Latest
      J:364150 Kak G, et al., CD4+ T cell-innate immune crosstalk is critical during Staphylococcus aureus craniotomy infection. JCI Insight. 2025 Feb 24;10(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory