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Satb1 Gene Detail
Summary
  • Symbol
    Satb1
  • Name
    special AT-rich sequence binding protein 1
  • Synonyms
    2610306G12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:105084
    NCBI Gene: 20230
  • Alliance
    genome feature page
  • Transcription Start Sites
    66 TSS
  • Regulated by
    Rr584 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr17:52043215-52140318 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 26.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1962 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105084
 protein coding gene Chr17:52043215-52140318 (-)
129S1/SvImJ ENSMUSG00200025926
 protein coding gene Chr17:47277149-47373921 (-)
A/J ENSMUSG00195019918
 protein coding gene Chr17:48747117-48843883 (-)
AKR/J ENSMUSG00220030419
 protein coding gene Chr17:47747132-47843884 (-)
BALB/cJ ENSMUSG00180023979
 protein coding gene Chr17:48503372-48600129 (-)
C3H/HeJ ENSMUSG00175014802
 protein coding gene Chr17:47810683-47907436 (-)
C57BL/6NJ ENSMUSG00215032950
 protein coding gene Chr17:47374419-47471544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021738
 protein coding gene Chr17:48474170-48571246 (-)
CAST/EiJ ENSTCUG00005021486
 protein coding gene Chr17:48586017-48682929 (-)
CBA/J ENSMUSG00210029525
 protein coding gene Chr17:47560230-47656988 (-)
DBA/2J ENSMUSG00185028858
 protein coding gene Chr17:50459346-50556094 (-)
FVB/NJ ENSMUSG00205018715
 protein coding gene Chr17:48044330-48141308 (-)
JF1/MsJ ENSUMUG00000010816
 protein coding gene Chr17:50200921-50298152 (-)
LP/J ENSMUSG00230040154
 protein coding gene Chr17:51388567-51485342 (-)
NOD/ShiLtJ ENSMUSG00190015197
 protein coding gene Chr17:47536151-47632906 (-)
NZO/HlLtJ ENSMUSG00225042379
 protein coding gene Chr17:53613034-53710143 (-)
PWK/PhJ ENSLUMG00010031831
 protein coding gene Chr17:47401523-47498774 (-)
SPRET/EiJ ENSMSPG00010030723
 protein coding gene Chr17:47621985-47718979 (-)
WSB/EiJ ENSIUOG00005027286
 protein coding gene Chr17:48428862-48525582 (-)



Homology
more
  • Human Ortholog
    SATB1, SATB homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SATB1, SATB homeobox 1
  • Synonyms
    DEFDA, DHDBV, KTZSL
  • Links
    NCBI Gene ID: 6304
    UniProt: Q01826

  • Chr Location
    3p24.3; chr3:18345377-18445621 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Satb1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for a targeted null mutation exhibit reduced size of the lymphoid organs, abnormal T cell development, general growth retardation and die by 3-4 weeks of age. Mice homozegous for a different targeted allele exhibit postnatal growth retardation and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    293
  • cDNA Data
    26
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20230 NCBI Gene Model | MGI Sequence Detail 97104 C57BL/6J ±  kb
    transcript NM_001357636 RefSeq | MGI Sequence Detail 6569 C57BL/6  
    polypeptide Q60611 UniProt | EBI | MGI Sequence Detail 764 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 32
      Primer pair 7
      Other 1
      Antibodies 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-32124, MGI:1917584, MGI:2147061
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 14
      Phenotypes 59
    • Earliest
      J:79264 Cohen-Tannoudji M, et al., Unexpected position-dependent expression of H-2 and beta 2-microglobulin/lacZ transgenes. Mol Reprod Dev. 1992 Oct;33(2):149-59
    • Latest
      J:383107 Molero AE, et al., Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington's disease pathogenesis. Neurobiol Dis. 2026 Apr;221:107297
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory